Number of lifetime menses increases breast cancer occurrence in postmenopausal women at high familial risk
It is increasingly thought that part of human susceptibility to cancer is the result of evolutionary mismatches: our ancestors evolved cancer suppression mechanisms in a world largely different from our modern environments. In that context, it has been shown in cohorts from general Western populatio...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Ecology and Evolution |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fevo.2023.912083/full |
| _version_ | 1797935690210607104 |
|---|---|
| author | Margaux Bieuville Margaux Bieuville Dominique Faugère Virginie Galibert Morgane Henard Antoine M. Dujon Antoine M. Dujon Beata Ujvari Pascal Pujol Pascal Pujol Benjamin Roche Frédéric Thomas |
| author_facet | Margaux Bieuville Margaux Bieuville Dominique Faugère Virginie Galibert Morgane Henard Antoine M. Dujon Antoine M. Dujon Beata Ujvari Pascal Pujol Pascal Pujol Benjamin Roche Frédéric Thomas |
| author_sort | Margaux Bieuville |
| collection | DOAJ |
| description | It is increasingly thought that part of human susceptibility to cancer is the result of evolutionary mismatches: our ancestors evolved cancer suppression mechanisms in a world largely different from our modern environments. In that context, it has been shown in cohorts from general Western populations that reproductive traits modulate breast cancer risk. Overall, the more menses women experience, the more at risk they are to develop postmenopausal breast cancer. This points towards an evolutionary mismatch but brings the question whether the reproductive pattern also modulates the breast cancer risk in menopausal women at high familial risk. We thus studied the influence of menses on breast cancer risk in a case–control study of 90 postmenopausal women (including BRCA1/2 and non BRCA1/2) nested within a cohort at high familial risk. We tested the association of the lifetime number of menses and the number of menses before first full-term pregnancy with postmenopausal breast cancer risk using Cox survival models. We showed that the total lifetime number of menses was significantly associated with postmenopausal breast cancer risk and associated with a quicker onset of breast cancer after menopause. Those results align with similar studies lead in general cohorts and suggest that the reproductive pattern modulates the familial risk of developing breast cancer after menopause. Altogether, those results impact how we envision breast cancer prevention and call for more research on how ecological and genetic factors shape breast cancer risk. |
| first_indexed | 2024-04-10T18:18:05Z |
| format | Article |
| id | doaj.art-894a1e07df3948fcae3dee97700bdd17 |
| institution | Directory Open Access Journal |
| issn | 2296-701X |
| language | English |
| last_indexed | 2024-04-10T18:18:05Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Ecology and Evolution |
| spelling | doaj.art-894a1e07df3948fcae3dee97700bdd172023-02-02T08:04:21ZengFrontiers Media S.A.Frontiers in Ecology and Evolution2296-701X2023-02-011110.3389/fevo.2023.912083912083Number of lifetime menses increases breast cancer occurrence in postmenopausal women at high familial riskMargaux Bieuville0Margaux Bieuville1Dominique Faugère2Virginie Galibert3Morgane Henard4Antoine M. Dujon5Antoine M. Dujon6Beata Ujvari7Pascal Pujol8Pascal Pujol9Benjamin Roche10Frédéric Thomas11CREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224–CNRS 5290, Université de Montpellier, Montpellier, FranceUMR 7206 Eco-Anthropologie (EA), Muséum National d'Histoire Naturelle, CNRS, Musée de l'Homme, Université Paris Cité, Paris, FranceCREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224–CNRS 5290, Université de Montpellier, Montpellier, FranceService Génétique Médicale, Maladies Rares et Médecine Personnalisée, Centre Hospitalier Universitaire de Montpellier, Montpellier, FranceCREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224–CNRS 5290, Université de Montpellier, Montpellier, FranceCREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224–CNRS 5290, Université de Montpellier, Montpellier, FranceCentre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC, AustraliaCentre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC, AustraliaCREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224–CNRS 5290, Université de Montpellier, Montpellier, FranceService Génétique Médicale, Maladies Rares et Médecine Personnalisée, Centre Hospitalier Universitaire de Montpellier, Montpellier, FranceCREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224–CNRS 5290, Université de Montpellier, Montpellier, FranceCREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224–CNRS 5290, Université de Montpellier, Montpellier, FranceIt is increasingly thought that part of human susceptibility to cancer is the result of evolutionary mismatches: our ancestors evolved cancer suppression mechanisms in a world largely different from our modern environments. In that context, it has been shown in cohorts from general Western populations that reproductive traits modulate breast cancer risk. Overall, the more menses women experience, the more at risk they are to develop postmenopausal breast cancer. This points towards an evolutionary mismatch but brings the question whether the reproductive pattern also modulates the breast cancer risk in menopausal women at high familial risk. We thus studied the influence of menses on breast cancer risk in a case–control study of 90 postmenopausal women (including BRCA1/2 and non BRCA1/2) nested within a cohort at high familial risk. We tested the association of the lifetime number of menses and the number of menses before first full-term pregnancy with postmenopausal breast cancer risk using Cox survival models. We showed that the total lifetime number of menses was significantly associated with postmenopausal breast cancer risk and associated with a quicker onset of breast cancer after menopause. Those results align with similar studies lead in general cohorts and suggest that the reproductive pattern modulates the familial risk of developing breast cancer after menopause. Altogether, those results impact how we envision breast cancer prevention and call for more research on how ecological and genetic factors shape breast cancer risk.https://www.frontiersin.org/articles/10.3389/fevo.2023.912083/fullevolutionary mismatchbreast cancerreproductive patternsurvival modelsmenopause |
| spellingShingle | Margaux Bieuville Margaux Bieuville Dominique Faugère Virginie Galibert Morgane Henard Antoine M. Dujon Antoine M. Dujon Beata Ujvari Pascal Pujol Pascal Pujol Benjamin Roche Frédéric Thomas Number of lifetime menses increases breast cancer occurrence in postmenopausal women at high familial risk Frontiers in Ecology and Evolution evolutionary mismatch breast cancer reproductive pattern survival models menopause |
| title | Number of lifetime menses increases breast cancer occurrence in postmenopausal women at high familial risk |
| title_full | Number of lifetime menses increases breast cancer occurrence in postmenopausal women at high familial risk |
| title_fullStr | Number of lifetime menses increases breast cancer occurrence in postmenopausal women at high familial risk |
| title_full_unstemmed | Number of lifetime menses increases breast cancer occurrence in postmenopausal women at high familial risk |
| title_short | Number of lifetime menses increases breast cancer occurrence in postmenopausal women at high familial risk |
| title_sort | number of lifetime menses increases breast cancer occurrence in postmenopausal women at high familial risk |
| topic | evolutionary mismatch breast cancer reproductive pattern survival models menopause |
| url | https://www.frontiersin.org/articles/10.3389/fevo.2023.912083/full |
| work_keys_str_mv | AT margauxbieuville numberoflifetimemensesincreasesbreastcanceroccurrenceinpostmenopausalwomenathighfamilialrisk AT margauxbieuville numberoflifetimemensesincreasesbreastcanceroccurrenceinpostmenopausalwomenathighfamilialrisk AT dominiquefaugere numberoflifetimemensesincreasesbreastcanceroccurrenceinpostmenopausalwomenathighfamilialrisk AT virginiegalibert numberoflifetimemensesincreasesbreastcanceroccurrenceinpostmenopausalwomenathighfamilialrisk AT morganehenard numberoflifetimemensesincreasesbreastcanceroccurrenceinpostmenopausalwomenathighfamilialrisk AT antoinemdujon numberoflifetimemensesincreasesbreastcanceroccurrenceinpostmenopausalwomenathighfamilialrisk AT antoinemdujon numberoflifetimemensesincreasesbreastcanceroccurrenceinpostmenopausalwomenathighfamilialrisk AT beataujvari numberoflifetimemensesincreasesbreastcanceroccurrenceinpostmenopausalwomenathighfamilialrisk AT pascalpujol numberoflifetimemensesincreasesbreastcanceroccurrenceinpostmenopausalwomenathighfamilialrisk AT pascalpujol numberoflifetimemensesincreasesbreastcanceroccurrenceinpostmenopausalwomenathighfamilialrisk AT benjaminroche numberoflifetimemensesincreasesbreastcanceroccurrenceinpostmenopausalwomenathighfamilialrisk AT fredericthomas numberoflifetimemensesincreasesbreastcanceroccurrenceinpostmenopausalwomenathighfamilialrisk |