Synthetic Biology’s Latest Trends in Antimicrobial Resistance and Biofilm
Recent instances of novel biological circuits that enable cells to gain biosynthetic skills demonstrate synthetic biology’s therapeutic potential. Synthetic biology is a branch of biology whose primary role is to build completely functional biological systems from the smallest basic elements such as...
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| Format: | Article |
| Language: | English |
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Journal of Pure and Applied Microbiology
2023-03-01
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| Series: | Journal of Pure and Applied Microbiology |
| Subjects: | |
| Online Access: | https://microbiologyjournal.org/synthetic-biologys-latest-trends-in-antimicrobial-resistance-and-biofilm/ |
| _version_ | 1797868085072363520 |
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| author | P.A. Aboobacker Latha Ragunathan Thiyagarajan Sanjeevi Aarthi Manoharan Aravind C. Sasi Vishnu Chandran Kavitha Kannaiyan Marcella Sherin Samuel |
| author_facet | P.A. Aboobacker Latha Ragunathan Thiyagarajan Sanjeevi Aarthi Manoharan Aravind C. Sasi Vishnu Chandran Kavitha Kannaiyan Marcella Sherin Samuel |
| author_sort | P.A. Aboobacker |
| collection | DOAJ |
| description | Recent instances of novel biological circuits that enable cells to gain biosynthetic skills demonstrate synthetic biology’s therapeutic potential. Synthetic biology is a branch of biology whose primary role is to build completely functional biological systems from the smallest basic elements such as DNA, proteins, and other organic molecules to complex bacteria. This review briefly mentions some novel way of synthetic strategies like bacterial modelling, two-component systems, synthetic peptide, and synthetic flavonoids used for targeting biofilm and drug-stable microbial communities. Bacterial modelling was mainly done in Escherichia coli and Mycoplasma using different strategies like introducing quorum sensing devices and CRISPR-mediated editing. Synthetic peptides are also one of the extensively studied ongoing areas which are produced from natural peptides taking as a template and altering amino acid position. Flavonoids are produced by two-step reaction and molecular hybridization methods. This kind of synthetic approach reported significant biofilm dispersion and lethal effects on clinically relevant bacteria like Pseudomonas aeruginosa, Staphylococcus aureus, E. coli, Acinetobacter baumannii, and Streptococcus species and Klebsiella pneumonia. |
| first_indexed | 2024-04-09T23:51:33Z |
| format | Article |
| id | doaj.art-894a4dc01aaa4b428437875ad6081bf5 |
| institution | Directory Open Access Journal |
| issn | 0973-7510 2581-690X |
| language | English |
| last_indexed | 2024-04-09T23:51:33Z |
| publishDate | 2023-03-01 |
| publisher | Journal of Pure and Applied Microbiology |
| record_format | Article |
| series | Journal of Pure and Applied Microbiology |
| spelling | doaj.art-894a4dc01aaa4b428437875ad6081bf52023-03-17T09:06:55ZengJournal of Pure and Applied MicrobiologyJournal of Pure and Applied Microbiology0973-75102581-690X2023-03-011712334https://doi.org/10.22207/JPAM.17.1.05Synthetic Biology’s Latest Trends in Antimicrobial Resistance and BiofilmP.A. Aboobackerhttps://orcid.org/0000-0002-2066-597XLatha Ragunathanhttps://orcid.org/0000-0003-2572-2678Thiyagarajan Sanjeevihttps://orcid.org/0000-0002-4006-7184Aarthi Manoharanhttps://orcid.org/0000-0003-2318-2786Aravind C. Sasihttps://orcid.org/0000-0003-1202-2015Vishnu Chandranhttps://orcid.org/0000-0001-7109-6220Kavitha Kannaiyanhttps://orcid.org/0000-0003-4837-5824Marcella Sherin Samuelhttps://orcid.org/0000-0001-5336-1895Recent instances of novel biological circuits that enable cells to gain biosynthetic skills demonstrate synthetic biology’s therapeutic potential. Synthetic biology is a branch of biology whose primary role is to build completely functional biological systems from the smallest basic elements such as DNA, proteins, and other organic molecules to complex bacteria. This review briefly mentions some novel way of synthetic strategies like bacterial modelling, two-component systems, synthetic peptide, and synthetic flavonoids used for targeting biofilm and drug-stable microbial communities. Bacterial modelling was mainly done in Escherichia coli and Mycoplasma using different strategies like introducing quorum sensing devices and CRISPR-mediated editing. Synthetic peptides are also one of the extensively studied ongoing areas which are produced from natural peptides taking as a template and altering amino acid position. Flavonoids are produced by two-step reaction and molecular hybridization methods. This kind of synthetic approach reported significant biofilm dispersion and lethal effects on clinically relevant bacteria like Pseudomonas aeruginosa, Staphylococcus aureus, E. coli, Acinetobacter baumannii, and Streptococcus species and Klebsiella pneumonia.https://microbiologyjournal.org/synthetic-biologys-latest-trends-in-antimicrobial-resistance-and-biofilm/synthetic peptidesbacterial modellingengineered phagemodified flavonoidsbacterial two-component system |
| spellingShingle | P.A. Aboobacker Latha Ragunathan Thiyagarajan Sanjeevi Aarthi Manoharan Aravind C. Sasi Vishnu Chandran Kavitha Kannaiyan Marcella Sherin Samuel Synthetic Biology’s Latest Trends in Antimicrobial Resistance and Biofilm Journal of Pure and Applied Microbiology synthetic peptides bacterial modelling engineered phage modified flavonoids bacterial two-component system |
| title | Synthetic Biology’s Latest Trends in Antimicrobial Resistance and Biofilm |
| title_full | Synthetic Biology’s Latest Trends in Antimicrobial Resistance and Biofilm |
| title_fullStr | Synthetic Biology’s Latest Trends in Antimicrobial Resistance and Biofilm |
| title_full_unstemmed | Synthetic Biology’s Latest Trends in Antimicrobial Resistance and Biofilm |
| title_short | Synthetic Biology’s Latest Trends in Antimicrobial Resistance and Biofilm |
| title_sort | synthetic biology s latest trends in antimicrobial resistance and biofilm |
| topic | synthetic peptides bacterial modelling engineered phage modified flavonoids bacterial two-component system |
| url | https://microbiologyjournal.org/synthetic-biologys-latest-trends-in-antimicrobial-resistance-and-biofilm/ |
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