Nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapy
Abstract Nanoengineered chitosan functionalized titanium dioxide biohybrids (CTiO2@NPs) were prepared with Amomum subulatum Roxb extract via one-pot green method and assessed by UV–Vis spectroscopy, XRD, SEM and EDAX analyses. As revealed by XRD pattern, the nanohybrids exhibits a rutile TiO2 crysta...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-52847-1 |
| _version_ | 1827327519752192000 |
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| author | Mohammad Shabib Akhtar Karthikeyan Chandrasekaran Sharmila Saminathan Siva Ranjani Rajalingam Nehal Mohsin Khalid Altigani Awad Alkarem Ahmed Yasir Alhazmi Ismail A. Walbi Basel A. Abdel-Wahab Amol D. Gholap Md. Faiyazuddin Gowri Sundaram |
| author_facet | Mohammad Shabib Akhtar Karthikeyan Chandrasekaran Sharmila Saminathan Siva Ranjani Rajalingam Nehal Mohsin Khalid Altigani Awad Alkarem Ahmed Yasir Alhazmi Ismail A. Walbi Basel A. Abdel-Wahab Amol D. Gholap Md. Faiyazuddin Gowri Sundaram |
| author_sort | Mohammad Shabib Akhtar |
| collection | DOAJ |
| description | Abstract Nanoengineered chitosan functionalized titanium dioxide biohybrids (CTiO2@NPs) were prepared with Amomum subulatum Roxb extract via one-pot green method and assessed by UV–Vis spectroscopy, XRD, SEM and EDAX analyses. As revealed by XRD pattern, the nanohybrids exhibits a rutile TiO2 crystallites around 45 nm in size. The emergence of the Ti–O–Ti bond is identified by observing a peak between 400 and 800 cm−1. A wide bandgap (4.8 eV) has been observed in CTiO2@NPs, due to the quantum confinement effects and the oxygen vacancies reveal the intriguing potential of developed nanohybrids for various applications. Surface flaws were identified by observing an emission band at 382, 437, 482, 517, and 556 nm. They also exhibit better antibacterial performances using well diffusion method against Staphylococcus aureus, Bacillus substilis, Klebsiella pneumonia, and Escherichia coli. CTiO2@NPs were discovered to have free radical scavenging activity on DPPH analysis and exhibit IC50 value as 95.80 μg/mL and standard (Vitamin C) IC50 is 87.62 μg/mL. CTiO2@NPs exhibited better anticancer properties against the osteosarcoma (MG-63) cell line. All these findings suggest that there is a forum for further useful therapeutic applications. Therefore, we claim that nano-engineered carbohydrated TiO2 phytohybrid is a promising solution for bacterial infections and bone cancer. |
| first_indexed | 2024-03-07T15:02:27Z |
| format | Article |
| id | doaj.art-894b0546f832469caa6c73ae4ed0d192 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:02:27Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-894b0546f832469caa6c73ae4ed0d1922024-03-05T19:03:43ZengNature PortfolioScientific Reports2045-23222024-02-0114111610.1038/s41598-024-52847-1Nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapyMohammad Shabib Akhtar0Karthikeyan Chandrasekaran1Sharmila Saminathan2Siva Ranjani Rajalingam3Nehal Mohsin4Khalid Altigani Awad Alkarem Ahmed5Yasir Alhazmi6Ismail A. Walbi7Basel A. Abdel-Wahab8Amol D. Gholap9Md. Faiyazuddin10Gowri Sundaram11Department of Clinical Pharmacy, College of Pharmacy, Najran UniversityDepartment of Chemical & Biochemical Engineering, Dongguk UniversityDepartment of Physics, Vel Tech Rangarajan Dr Sagunthala R&D Institute of Science and TechnologyPG & Research Department of Physics, Cauvery College for WomenDepartment of Clinical Pharmacy, College of Pharmacy, Najran UniversityDepartment of Clinical Pharmacy, College of Pharmacy, Najran UniversityDepartment of Clinical Pharmacy, College of Pharmacy, Najran UniversityDepartment of Clinical Pharmacy, College of Pharmacy, Najran UniversityDepartment of Pharmacology, College of Pharmacy, Najran UniversityDepartment of Pharmaceutics, St. John Institute of Pharmacy and ResearchSchool of Pharmacy, Al–Karim UniversityPG & Research Department of Physics, Cauvery College for WomenAbstract Nanoengineered chitosan functionalized titanium dioxide biohybrids (CTiO2@NPs) were prepared with Amomum subulatum Roxb extract via one-pot green method and assessed by UV–Vis spectroscopy, XRD, SEM and EDAX analyses. As revealed by XRD pattern, the nanohybrids exhibits a rutile TiO2 crystallites around 45 nm in size. The emergence of the Ti–O–Ti bond is identified by observing a peak between 400 and 800 cm−1. A wide bandgap (4.8 eV) has been observed in CTiO2@NPs, due to the quantum confinement effects and the oxygen vacancies reveal the intriguing potential of developed nanohybrids for various applications. Surface flaws were identified by observing an emission band at 382, 437, 482, 517, and 556 nm. They also exhibit better antibacterial performances using well diffusion method against Staphylococcus aureus, Bacillus substilis, Klebsiella pneumonia, and Escherichia coli. CTiO2@NPs were discovered to have free radical scavenging activity on DPPH analysis and exhibit IC50 value as 95.80 μg/mL and standard (Vitamin C) IC50 is 87.62 μg/mL. CTiO2@NPs exhibited better anticancer properties against the osteosarcoma (MG-63) cell line. All these findings suggest that there is a forum for further useful therapeutic applications. Therefore, we claim that nano-engineered carbohydrated TiO2 phytohybrid is a promising solution for bacterial infections and bone cancer.https://doi.org/10.1038/s41598-024-52847-1 |
| spellingShingle | Mohammad Shabib Akhtar Karthikeyan Chandrasekaran Sharmila Saminathan Siva Ranjani Rajalingam Nehal Mohsin Khalid Altigani Awad Alkarem Ahmed Yasir Alhazmi Ismail A. Walbi Basel A. Abdel-Wahab Amol D. Gholap Md. Faiyazuddin Gowri Sundaram Nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapy Scientific Reports |
| title | Nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapy |
| title_full | Nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapy |
| title_fullStr | Nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapy |
| title_full_unstemmed | Nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapy |
| title_short | Nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapy |
| title_sort | nanoengineered chitosan functionalized titanium dioxide biohybrids for bacterial infections and cancer therapy |
| url | https://doi.org/10.1038/s41598-024-52847-1 |
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