An 8-month adapted motor activity program in a young CMT1A male patient

Background:It is unclear whether prolonged periods of training can be well tolerated. In Charcot-Marie Tooth disease (CMT). We report the effects of an 8-month, adapted motor activity (AMA) program in a 16-years-old CMT1A male patient. The program included strength, mobility, and balance training (t...

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Main Authors: Giorgio Bottoni, Oscar Crisafulli, Caterina Pisegna, Marco Serra, Sara Brambilla, Fausto Feletti, Giovanni Cremonte, Giuseppe D’Antona
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2024.1347319/full
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author Giorgio Bottoni
Oscar Crisafulli
Caterina Pisegna
Marco Serra
Sara Brambilla
Fausto Feletti
Giovanni Cremonte
Giuseppe D’Antona
Giuseppe D’Antona
author_facet Giorgio Bottoni
Oscar Crisafulli
Caterina Pisegna
Marco Serra
Sara Brambilla
Fausto Feletti
Giovanni Cremonte
Giuseppe D’Antona
Giuseppe D’Antona
author_sort Giorgio Bottoni
collection DOAJ
description Background:It is unclear whether prolonged periods of training can be well tolerated. In Charcot-Marie Tooth disease (CMT). We report the effects of an 8-month, adapted motor activity (AMA) program in a 16-years-old CMT1A male patient. The program included strength, mobility, and balance training (two sessions per week, 1 h per session).Measures:Walking ability and walking velocity (Six-Minute Walking Test—6MWT, Ten Meters Walking Test—10 mW T), balance (Y-Balance Test—YBT, Berg Balance Scale—BBS), functional mobility (Short Physical Performance Battery—Short physical performance battery), fatigue (Checklist Individual strength questionnaire - CIS20R), health and quality of life (Short Form Health Survey 36 questionnaire—SF-36) were evaluated in three moments: before (T0), after 5 (T1) and 8 (T2) months of adapted motor activity. Dorsal and plantar foot flexion strength (Maximal Voluntary Contraction—maximum voluntary contraction) and neuromuscular functions (Electromyography—sEMG, interpolated twitch technique—ITT) were measured at T1 and T2.Results:Relative to T0, an amelioration of walking ability (6MWT, +9,3%) and balance (with improvements on Y-balance composite normalized mean reach of the right and left limb of 15,3% and 8,5%, respectively) was appreciable. Relative to T1, an increase in foot strength in three out of four movements (right plantar flexion, +39,3%, left plantar flexion, +22,7%, left dorsal flexion, 11,5%) was observed. Concerning voluntary muscle activation, a greater recruitment in the left, unlike right, medial gastrocnemius was observed.Conclusion:Results suggest the safety of an 8-month AMA program in a young patient affected by CMT1A.
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spelling doaj.art-894d484bff18480089918193147f7bf42024-04-05T04:58:13ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2024-04-011510.3389/fphys.2024.13473191347319An 8-month adapted motor activity program in a young CMT1A male patientGiorgio Bottoni0Oscar Crisafulli1Caterina Pisegna2Marco Serra3Sara Brambilla4Fausto Feletti5Giovanni Cremonte6Giuseppe D’Antona7Giuseppe D’Antona8CRIAMS Sport Medicine Centre Voghera, University of Pavia, Voghera, ItalyCRIAMS Sport Medicine Centre Voghera, University of Pavia, Voghera, ItalyNeurology Operative Unit, Civilian Hospital of Voghera, Voghera, ItalyCRIAMS Sport Medicine Centre Voghera, University of Pavia, Voghera, ItalyCRIAMS Sport Medicine Centre Voghera, University of Pavia, Voghera, ItalyDepartment of Internal Medicine, University of Pavia, Pavia, ItalyCRIAMS Sport Medicine Centre Voghera, University of Pavia, Voghera, ItalyCRIAMS Sport Medicine Centre Voghera, University of Pavia, Voghera, ItalyDepartment of Public Health Experimental and Forensic Medicine, University of Pavia, Voghera, ItalyBackground:It is unclear whether prolonged periods of training can be well tolerated. In Charcot-Marie Tooth disease (CMT). We report the effects of an 8-month, adapted motor activity (AMA) program in a 16-years-old CMT1A male patient. The program included strength, mobility, and balance training (two sessions per week, 1 h per session).Measures:Walking ability and walking velocity (Six-Minute Walking Test—6MWT, Ten Meters Walking Test—10 mW T), balance (Y-Balance Test—YBT, Berg Balance Scale—BBS), functional mobility (Short Physical Performance Battery—Short physical performance battery), fatigue (Checklist Individual strength questionnaire - CIS20R), health and quality of life (Short Form Health Survey 36 questionnaire—SF-36) were evaluated in three moments: before (T0), after 5 (T1) and 8 (T2) months of adapted motor activity. Dorsal and plantar foot flexion strength (Maximal Voluntary Contraction—maximum voluntary contraction) and neuromuscular functions (Electromyography—sEMG, interpolated twitch technique—ITT) were measured at T1 and T2.Results:Relative to T0, an amelioration of walking ability (6MWT, +9,3%) and balance (with improvements on Y-balance composite normalized mean reach of the right and left limb of 15,3% and 8,5%, respectively) was appreciable. Relative to T1, an increase in foot strength in three out of four movements (right plantar flexion, +39,3%, left plantar flexion, +22,7%, left dorsal flexion, 11,5%) was observed. Concerning voluntary muscle activation, a greater recruitment in the left, unlike right, medial gastrocnemius was observed.Conclusion:Results suggest the safety of an 8-month AMA program in a young patient affected by CMT1A.https://www.frontiersin.org/articles/10.3389/fphys.2024.1347319/fullCharcot-Marie-ToothNeuropathyExerciseBalancegait
spellingShingle Giorgio Bottoni
Oscar Crisafulli
Caterina Pisegna
Marco Serra
Sara Brambilla
Fausto Feletti
Giovanni Cremonte
Giuseppe D’Antona
Giuseppe D’Antona
An 8-month adapted motor activity program in a young CMT1A male patient
Frontiers in Physiology
Charcot-Marie-Tooth
Neuropathy
Exercise
Balance
gait
title An 8-month adapted motor activity program in a young CMT1A male patient
title_full An 8-month adapted motor activity program in a young CMT1A male patient
title_fullStr An 8-month adapted motor activity program in a young CMT1A male patient
title_full_unstemmed An 8-month adapted motor activity program in a young CMT1A male patient
title_short An 8-month adapted motor activity program in a young CMT1A male patient
title_sort 8 month adapted motor activity program in a young cmt1a male patient
topic Charcot-Marie-Tooth
Neuropathy
Exercise
Balance
gait
url https://www.frontiersin.org/articles/10.3389/fphys.2024.1347319/full
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