New oxadiazole derivatives of isonicotinohydrazide in the search for antimicrobial agents: Synthesis and in vitro evaluation

New oxadiazole derivatives of isonicotinohydrazide in the search for antimicrobial agents: Synthesis and in vitro evaluation

Structural modification of the front line antitubercular drug isoniazid provide a lipophilic adaptations of the drug in which hydrazide moiety of isoniazid is replaced by 1,3,4-oxadiazole heterocycles to eliminate in-vivo acetylation by arylamine N-acetyltransferase which results to form inactive...

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Bibliographic Details
Main Authors:	Malhotra Manav, Sanduja Mohit, Samad Abdul, Deep Aakash
Format:	Article
Language:	English
Published:	Serbian Chemical Society 2012-01-01
Series:	Journal of the Serbian Chemical Society
Subjects:	1,3,4-oxadiazoles antimicrobial activity isoniazid mannich bases lipophilicity
Online Access:	http://www.doiserbia.nb.rs/img/doi/0352-5139/2012/0352-51391100155M.pdf

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