p97/VCP targets Toxoplasma gondii vacuoles for parasite restriction in interferon-stimulated human cells

p97/VCP targets Toxoplasma gondii vacuoles for parasite restriction in interferon-stimulated human cells

ABSTRACTInfection with the parasite Toxoplasma gondii leads to production of interferon gamma (IFNγ) that stimulates cells to upregulate defense proteins targeting the parasite for cell intrinsic elimination or growth restriction. Various host defense mechanisms operate at the parasitophorous vacuol...

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Bibliographic Details
Main Authors: Barbara Clough, Daniel Fisch, Todd H. Mize, Vesela Encheva, Ambrosius Snijders, Eva-Maria Frickel
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mSphere
Subjects:
Toxoplasma gondii
innate immunity
parasitophorous vacuole
ubiquitin
ANKRD13A
p97/VCP
Online Access:https://journals.asm.org/doi/10.1128/msphere.00511-23

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