Ten-Year Research Update Review: Antiviral Activities from Marine Organisms
Oceans cover more than 70 percent of the surface of our planet and are characterized by huge taxonomic and chemical diversity of marine organisms. Several studies have shown that marine organisms produce a variety of compounds, derived from primary or secondary metabolism, which may have antiviral a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/7/1007 |
| _version_ | 1827713560306778112 |
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| author | Gennaro Riccio Nadia Ruocco Mirko Mutalipassi Maria Costantini Valerio Zupo Daniela Coppola Donatella de Pascale Chiara Lauritano |
| author_facet | Gennaro Riccio Nadia Ruocco Mirko Mutalipassi Maria Costantini Valerio Zupo Daniela Coppola Donatella de Pascale Chiara Lauritano |
| author_sort | Gennaro Riccio |
| collection | DOAJ |
| description | Oceans cover more than 70 percent of the surface of our planet and are characterized by huge taxonomic and chemical diversity of marine organisms. Several studies have shown that marine organisms produce a variety of compounds, derived from primary or secondary metabolism, which may have antiviral activities. In particular, certain marine metabolites are active towards a plethora of viruses. Multiple mechanisms of action have been found, as well as different targets. This review gives an overview of the marine-derived compounds discovered in the last 10 years. Even if marine organisms produce a wide variety of different compounds, there is only one compound available on the market, Ara-A, and only another one is in phase I clinical trials, named Griffithsin. The recent pandemic emergency caused by SARS-CoV-2, also known as COVID-19, highlights the need to further invest in this field, in order to shed light on marine compound potentiality and discover new drugs from the sea. |
| first_indexed | 2024-03-10T18:37:38Z |
| format | Article |
| id | doaj.art-89546330d0ee43f68f2e0570de72cd49 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T18:37:38Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-89546330d0ee43f68f2e0570de72cd492023-11-20T06:05:40ZengMDPI AGBiomolecules2218-273X2020-07-01107100710.3390/biom10071007Ten-Year Research Update Review: Antiviral Activities from Marine OrganismsGennaro Riccio0Nadia Ruocco1Mirko Mutalipassi2Maria Costantini3Valerio Zupo4Daniela Coppola5Donatella de Pascale6Chiara Lauritano7Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, CAP, 80121 Naples, ItalyMarine Biotechnology Department, Stazione Zoologica Anton Dohrn, CAP, 80121 Naples, ItalyMarine Biotechnology Department, Stazione Zoologica Anton Dohrn, CAP, 80121 Naples, ItalyMarine Biotechnology Department, Stazione Zoologica Anton Dohrn, CAP, 80121 Naples, ItalyMarine Biotechnology Department, Stazione Zoologica Anton Dohrn, CAP, 80121 Naples, ItalyMarine Biotechnology Department, Stazione Zoologica Anton Dohrn, CAP, 80121 Naples, ItalyMarine Biotechnology Department, Stazione Zoologica Anton Dohrn, CAP, 80121 Naples, ItalyMarine Biotechnology Department, Stazione Zoologica Anton Dohrn, CAP, 80121 Naples, ItalyOceans cover more than 70 percent of the surface of our planet and are characterized by huge taxonomic and chemical diversity of marine organisms. Several studies have shown that marine organisms produce a variety of compounds, derived from primary or secondary metabolism, which may have antiviral activities. In particular, certain marine metabolites are active towards a plethora of viruses. Multiple mechanisms of action have been found, as well as different targets. This review gives an overview of the marine-derived compounds discovered in the last 10 years. Even if marine organisms produce a wide variety of different compounds, there is only one compound available on the market, Ara-A, and only another one is in phase I clinical trials, named Griffithsin. The recent pandemic emergency caused by SARS-CoV-2, also known as COVID-19, highlights the need to further invest in this field, in order to shed light on marine compound potentiality and discover new drugs from the sea.https://www.mdpi.com/2218-273X/10/7/1007marine organismsantiviralmarine natural productsviruses |
| spellingShingle | Gennaro Riccio Nadia Ruocco Mirko Mutalipassi Maria Costantini Valerio Zupo Daniela Coppola Donatella de Pascale Chiara Lauritano Ten-Year Research Update Review: Antiviral Activities from Marine Organisms Biomolecules marine organisms antiviral marine natural products viruses |
| title | Ten-Year Research Update Review: Antiviral Activities from Marine Organisms |
| title_full | Ten-Year Research Update Review: Antiviral Activities from Marine Organisms |
| title_fullStr | Ten-Year Research Update Review: Antiviral Activities from Marine Organisms |
| title_full_unstemmed | Ten-Year Research Update Review: Antiviral Activities from Marine Organisms |
| title_short | Ten-Year Research Update Review: Antiviral Activities from Marine Organisms |
| title_sort | ten year research update review antiviral activities from marine organisms |
| topic | marine organisms antiviral marine natural products viruses |
| url | https://www.mdpi.com/2218-273X/10/7/1007 |
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