Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases
Objective Endoplasmic reticulum (ER) stress is involved in the pathogenesis of various ophthalmic diseases, and ER stress-mediated degradation systems play an important role in maintaining ER homeostasis during ER stress. The purpose of this review is to explore the potential relationship between th...
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| Format: | Article |
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PeerJ Inc.
2020-02-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/8638.pdf |
| _version_ | 1797425552174350336 |
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| author | Jing-Yao Song Xue-Guang Wang Zi-Yuan Zhang Lin Che Bin Fan Guang-Yu Li |
| author_facet | Jing-Yao Song Xue-Guang Wang Zi-Yuan Zhang Lin Che Bin Fan Guang-Yu Li |
| author_sort | Jing-Yao Song |
| collection | DOAJ |
| description | Objective Endoplasmic reticulum (ER) stress is involved in the pathogenesis of various ophthalmic diseases, and ER stress-mediated degradation systems play an important role in maintaining ER homeostasis during ER stress. The purpose of this review is to explore the potential relationship between them and to find their equilibrium sites. Design This review illustrates the important role of reasonable regulation of the protein degradation system in ER stress-mediated ophthalmic diseases. There were 128 articles chosen for review in this study, and the keywords used for article research are ER stress, autophagy, UPS, ophthalmic disease, and ocular. Data sources The data are from Web of Science, PubMed, with no language restrictions from inception until 2019 Jul. Results The ubiquitin proteasome system (UPS) and autophagy are important degradation systems in ER stress. They can restore ER homeostasis, but if ER stress cannot be relieved in time, cell death may occur. However, they are not independent of each other, and the relationship between them is complementary. Therefore, we propose that ER stability can be achieved by adjusting the balance between them. Conclusion The degradation system of ER stress, UPS and autophagy are interrelated. Because an imbalance between the UPS and autophagy can cause cell death, regulating that balance may suppress ER stress and protect cells against pathological stress damage. |
| first_indexed | 2024-03-09T08:17:45Z |
| format | Article |
| id | doaj.art-8958b34d7c844407916344a8cb6a0e95 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T08:17:45Z |
| publishDate | 2020-02-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-8958b34d7c844407916344a8cb6a0e952023-12-02T21:59:49ZengPeerJ Inc.PeerJ2167-83592020-02-018e863810.7717/peerj.8638Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseasesJing-Yao Song0Xue-Guang Wang1Zi-Yuan Zhang2Lin Che3Bin Fan4Guang-Yu Li5Department of Ophthalmology, Second Hospital of Jilin University, ChangChun, ChinaDepartment of Traumatic Orthopedics, Third People’s Hospital of Jinan, Jinan, ChinaDepartment of Ophthalmology, Second Hospital of Jilin University, ChangChun, ChinaDepartment of Ophthalmology, Second Hospital of Jilin University, ChangChun, ChinaDepartment of Ophthalmology, Second Hospital of Jilin University, ChangChun, ChinaDepartment of Ophthalmology, Second Hospital of Jilin University, ChangChun, ChinaObjective Endoplasmic reticulum (ER) stress is involved in the pathogenesis of various ophthalmic diseases, and ER stress-mediated degradation systems play an important role in maintaining ER homeostasis during ER stress. The purpose of this review is to explore the potential relationship between them and to find their equilibrium sites. Design This review illustrates the important role of reasonable regulation of the protein degradation system in ER stress-mediated ophthalmic diseases. There were 128 articles chosen for review in this study, and the keywords used for article research are ER stress, autophagy, UPS, ophthalmic disease, and ocular. Data sources The data are from Web of Science, PubMed, with no language restrictions from inception until 2019 Jul. Results The ubiquitin proteasome system (UPS) and autophagy are important degradation systems in ER stress. They can restore ER homeostasis, but if ER stress cannot be relieved in time, cell death may occur. However, they are not independent of each other, and the relationship between them is complementary. Therefore, we propose that ER stability can be achieved by adjusting the balance between them. Conclusion The degradation system of ER stress, UPS and autophagy are interrelated. Because an imbalance between the UPS and autophagy can cause cell death, regulating that balance may suppress ER stress and protect cells against pathological stress damage.https://peerj.com/articles/8638.pdfER stressAutophagyUPSOphthalmic diseaseOcular |
| spellingShingle | Jing-Yao Song Xue-Guang Wang Zi-Yuan Zhang Lin Che Bin Fan Guang-Yu Li Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases PeerJ ER stress Autophagy UPS Ophthalmic disease Ocular |
| title | Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases |
| title_full | Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases |
| title_fullStr | Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases |
| title_full_unstemmed | Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases |
| title_short | Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases |
| title_sort | endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases |
| topic | ER stress Autophagy UPS Ophthalmic disease Ocular |
| url | https://peerj.com/articles/8638.pdf |
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