Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana.
<h4>Background</h4>As prevalence decreases in pre-elimination settings, identifying the spatial distribution of remaining infections to target control measures becomes increasingly challenging. By measuring multiple antibody responses indicative of past exposure to different pathogens, i...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-03-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0010227 |
| _version_ | 1811248445798744064 |
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| author | Kimberly M Fornace Laura Senyonjo Diana L Martin Sarah Gwyn Elena Schmidt David Agyemang Benjamin Marfo James Addy Ernest Mensah Anthony W Solomon Robin Bailey Chris J Drakeley Rachel L Pullan |
| author_facet | Kimberly M Fornace Laura Senyonjo Diana L Martin Sarah Gwyn Elena Schmidt David Agyemang Benjamin Marfo James Addy Ernest Mensah Anthony W Solomon Robin Bailey Chris J Drakeley Rachel L Pullan |
| author_sort | Kimberly M Fornace |
| collection | DOAJ |
| description | <h4>Background</h4>As prevalence decreases in pre-elimination settings, identifying the spatial distribution of remaining infections to target control measures becomes increasingly challenging. By measuring multiple antibody responses indicative of past exposure to different pathogens, integrated serological surveys enable simultaneous characterisation of residual transmission of multiple pathogens.<h4>Methodology/principal findings</h4>Here, we combine integrated serological surveys with geostatistical modelling and remote sensing-derived environmental data to estimate the spatial distribution of exposure to multiple diseases in children in Northern Ghana. The study utilised the trachoma surveillance survey platform (cross-sectional two-stage cluster-sampled surveys) to collect information on additional identified diseases at different stages of elimination with minimal additional cost. Geostatistical modelling of serological data allowed identification of areas with high probabilities of recent exposure to diseases of interest, including areas previously unknown to control programmes. We additionally demonstrate how serological surveys can be used to identify areas with exposure to multiple diseases and to prioritise areas with high uncertainty for future surveys. Modelled estimates of cluster-level prevalence were strongly correlated with more operationally feasible metrics of antibody responses.<h4>Conclusions/significance</h4>This study demonstrates the potential of integrated serological surveillance to characterise spatial distributions of exposure to multiple pathogens in low transmission and elimination settings when the probability of detecting infections is low. |
| first_indexed | 2024-04-12T15:28:08Z |
| format | Article |
| id | doaj.art-895af05547b047f69b13744c11be7836 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-12T15:28:08Z |
| publishDate | 2022-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-895af05547b047f69b13744c11be78362022-12-22T03:27:12ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352022-03-01163e001022710.1371/journal.pntd.0010227Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana.Kimberly M FornaceLaura SenyonjoDiana L MartinSarah GwynElena SchmidtDavid AgyemangBenjamin MarfoJames AddyErnest MensahAnthony W SolomonRobin BaileyChris J DrakeleyRachel L Pullan<h4>Background</h4>As prevalence decreases in pre-elimination settings, identifying the spatial distribution of remaining infections to target control measures becomes increasingly challenging. By measuring multiple antibody responses indicative of past exposure to different pathogens, integrated serological surveys enable simultaneous characterisation of residual transmission of multiple pathogens.<h4>Methodology/principal findings</h4>Here, we combine integrated serological surveys with geostatistical modelling and remote sensing-derived environmental data to estimate the spatial distribution of exposure to multiple diseases in children in Northern Ghana. The study utilised the trachoma surveillance survey platform (cross-sectional two-stage cluster-sampled surveys) to collect information on additional identified diseases at different stages of elimination with minimal additional cost. Geostatistical modelling of serological data allowed identification of areas with high probabilities of recent exposure to diseases of interest, including areas previously unknown to control programmes. We additionally demonstrate how serological surveys can be used to identify areas with exposure to multiple diseases and to prioritise areas with high uncertainty for future surveys. Modelled estimates of cluster-level prevalence were strongly correlated with more operationally feasible metrics of antibody responses.<h4>Conclusions/significance</h4>This study demonstrates the potential of integrated serological surveillance to characterise spatial distributions of exposure to multiple pathogens in low transmission and elimination settings when the probability of detecting infections is low.https://doi.org/10.1371/journal.pntd.0010227 |
| spellingShingle | Kimberly M Fornace Laura Senyonjo Diana L Martin Sarah Gwyn Elena Schmidt David Agyemang Benjamin Marfo James Addy Ernest Mensah Anthony W Solomon Robin Bailey Chris J Drakeley Rachel L Pullan Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana. PLoS Neglected Tropical Diseases |
| title | Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana. |
| title_full | Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana. |
| title_fullStr | Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana. |
| title_full_unstemmed | Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana. |
| title_short | Characterising spatial patterns of neglected tropical disease transmission using integrated sero-surveillance in Northern Ghana. |
| title_sort | characterising spatial patterns of neglected tropical disease transmission using integrated sero surveillance in northern ghana |
| url | https://doi.org/10.1371/journal.pntd.0010227 |
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