Process Optimization and DOE Application in the Synthesis of Rociletinib Intermediate
Critical step of Rociletinib synthesis, regioselective nucleophilic aromatic substitution of C-2 chlorine at pyrimidine molecule 3 with amine 2, was optimised by implementation of pre-DoE screening and DoE-based algorithms. The synthesis reaction was developed and optimised by following a quality b...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Croatian Society of Chemical Engineers
2018-07-01
|
| Series: | Chemical and Biochemical Engineering Quarterly |
| Subjects: | |
| Online Access: | http://silverstripe.fkit.hr/cabeq/assets/Uploads/02-2-18.pdf |