Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner

Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner

The role of compartmentalized signaling in primary cilia during tissue morphogenesis is not well understood. The cilia localized G protein-coupled receptor, Gpr161, represses hedgehog pathway via cAMP signaling. We engineered a knock-in at the Gpr161 locus in mice to generate a variant (Gpr161mut1),...

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Bibliographic Details
Main Authors: Sun-Hee Hwang, Bandarigoda N Somatilaka, Kevin White, Saikat Mukhopadhyay
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
cilia
hedgehog
cAMP
morphogenesis
Gpr161
Gli repressor
Online Access:https://elifesciences.org/articles/67121

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