Metabolic Cooperation among Commensal Bacteria Supports Drosophila Juvenile Growth under Nutritional Stress
Summary: The gut microbiota shapes animal growth trajectory in stressful nutritional environments, but the molecular mechanisms behind such physiological benefits remain poorly understood. The gut microbiota is mostly composed of bacteria, which construct metabolic networks among themselves and with...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422030417X |
| _version_ | 1818037031166541824 |
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| author | Jessika Consuegra Théodore Grenier Houssam Akherraz Isabelle Rahioui Hugo Gervais Pedro da Silva François Leulier |
| author_facet | Jessika Consuegra Théodore Grenier Houssam Akherraz Isabelle Rahioui Hugo Gervais Pedro da Silva François Leulier |
| author_sort | Jessika Consuegra |
| collection | DOAJ |
| description | Summary: The gut microbiota shapes animal growth trajectory in stressful nutritional environments, but the molecular mechanisms behind such physiological benefits remain poorly understood. The gut microbiota is mostly composed of bacteria, which construct metabolic networks among themselves and with the host. Until now, how the metabolic activities of the microbiota contribute to host juvenile growth remains unknown. Here, using Drosophila as a host model, we report that two of its major bacterial partners, Lactobacillus plantarum and Acetobacter pomorum, engage in a beneficial metabolic dialogue that boosts host juvenile growth despite nutritional stress. We pinpoint that lactate, produced by L. plantarum, is utilized by A. pomorum as an additional carbon source, and A. pomorum provides essential amino acids and vitamins to L. plantarum. Such bacterial cross-feeding provisions a set of anabolic metabolites to the host, which may foster host systemic growth despite poor nutrition. |
| first_indexed | 2024-12-10T07:20:22Z |
| format | Article |
| id | doaj.art-895d8421077a458a871e72f09a432f6b |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-10T07:20:22Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-895d8421077a458a871e72f09a432f6b2022-12-22T01:57:50ZengElsevieriScience2589-00422020-06-01236101232Metabolic Cooperation among Commensal Bacteria Supports Drosophila Juvenile Growth under Nutritional StressJessika Consuegra0Théodore Grenier1Houssam Akherraz2Isabelle Rahioui3Hugo Gervais4Pedro da Silva5François Leulier6Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, UMR5242, 69364 Cedex 07, Lyon, France; Corresponding authorInstitut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, UMR5242, 69364 Cedex 07, Lyon, FranceInstitut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, UMR5242, 69364 Cedex 07, Lyon, FranceLaboratoire Biologie Fonctionnelle, Insectes et Interactions, Université de Lyon, Institut National des Sciences Appliquées, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement, UMR0203, 69621 Villeurbanne, FranceInstitut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, UMR5242, 69364 Cedex 07, Lyon, FranceLaboratoire Biologie Fonctionnelle, Insectes et Interactions, Université de Lyon, Institut National des Sciences Appliquées, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement, UMR0203, 69621 Villeurbanne, FranceInstitut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, UMR5242, 69364 Cedex 07, Lyon, France; Corresponding authorSummary: The gut microbiota shapes animal growth trajectory in stressful nutritional environments, but the molecular mechanisms behind such physiological benefits remain poorly understood. The gut microbiota is mostly composed of bacteria, which construct metabolic networks among themselves and with the host. Until now, how the metabolic activities of the microbiota contribute to host juvenile growth remains unknown. Here, using Drosophila as a host model, we report that two of its major bacterial partners, Lactobacillus plantarum and Acetobacter pomorum, engage in a beneficial metabolic dialogue that boosts host juvenile growth despite nutritional stress. We pinpoint that lactate, produced by L. plantarum, is utilized by A. pomorum as an additional carbon source, and A. pomorum provides essential amino acids and vitamins to L. plantarum. Such bacterial cross-feeding provisions a set of anabolic metabolites to the host, which may foster host systemic growth despite poor nutrition.http://www.sciencedirect.com/science/article/pii/S258900422030417XBiological SciencesMicrobiologyMicrobiome |
| spellingShingle | Jessika Consuegra Théodore Grenier Houssam Akherraz Isabelle Rahioui Hugo Gervais Pedro da Silva François Leulier Metabolic Cooperation among Commensal Bacteria Supports Drosophila Juvenile Growth under Nutritional Stress iScience Biological Sciences Microbiology Microbiome |
| title | Metabolic Cooperation among Commensal Bacteria Supports Drosophila Juvenile Growth under Nutritional Stress |
| title_full | Metabolic Cooperation among Commensal Bacteria Supports Drosophila Juvenile Growth under Nutritional Stress |
| title_fullStr | Metabolic Cooperation among Commensal Bacteria Supports Drosophila Juvenile Growth under Nutritional Stress |
| title_full_unstemmed | Metabolic Cooperation among Commensal Bacteria Supports Drosophila Juvenile Growth under Nutritional Stress |
| title_short | Metabolic Cooperation among Commensal Bacteria Supports Drosophila Juvenile Growth under Nutritional Stress |
| title_sort | metabolic cooperation among commensal bacteria supports drosophila juvenile growth under nutritional stress |
| topic | Biological Sciences Microbiology Microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S258900422030417X |
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