Cytomegalovirus Retinitis and Retinal Detachment following Chimeric Antigen Receptor T Cell Therapy for Relapsed/Refractory Multiple Myeloma
Cytomegalovirus (CMV) retinitis is a rare end-organ disease of CMV infection and is a marker of severe immunosuppression, especially in human immunodeficiency virus (HIV)-positive patients. In multiple myeloma (MM) patients, CMV retinitis has been reported in the post-transplant setting, with an inc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/29/2/44 |
| _version_ | 1797481425791877120 |
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| author | Cheng Zu Yufeng Xu Yiyun Wang Mingming Zhang Houli Zhao Xiaoyun Fang He Huang Yongxian Hu |
| author_facet | Cheng Zu Yufeng Xu Yiyun Wang Mingming Zhang Houli Zhao Xiaoyun Fang He Huang Yongxian Hu |
| author_sort | Cheng Zu |
| collection | DOAJ |
| description | Cytomegalovirus (CMV) retinitis is a rare end-organ disease of CMV infection and is a marker of severe immunosuppression, especially in human immunodeficiency virus (HIV)-positive patients. In multiple myeloma (MM) patients, CMV retinitis has been reported in the post-transplant setting, with an incidence lower than 0.2%, and in patients receiving lenalidomide. Here, we describe the first case of CMV retinitis in myeloma patients following B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor T (BCMA CAR-T) cell therapy. In addition to CMV, the patient developed multiple infections including a mouth ulcer, pneumonia, and fungal enteritis. While the complete remission (CR) status of MM was maintained, he regained a visual acuity of 20/1000 after appropriate ophthalmologic treatment. This single case illustrates the potential of BCMA CAR-T therapy to induce profound humoral immunosuppression, and demonstrates an imperative need for an established standard of monitoring and prophylaxis of post-CAR-T infections. |
| first_indexed | 2024-03-09T22:14:23Z |
| format | Article |
| id | doaj.art-895e9555f2e9403caf6212c0f00820b1 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T22:14:23Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-895e9555f2e9403caf6212c0f00820b12023-11-23T19:26:30ZengMDPI AGCurrent Oncology1198-00521718-77292022-01-0129249049610.3390/curroncol29020044Cytomegalovirus Retinitis and Retinal Detachment following Chimeric Antigen Receptor T Cell Therapy for Relapsed/Refractory Multiple MyelomaCheng Zu0Yufeng Xu1Yiyun Wang2Mingming Zhang3Houli Zhao4Xiaoyun Fang5He Huang6Yongxian Hu7Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaEye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaEye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaCytomegalovirus (CMV) retinitis is a rare end-organ disease of CMV infection and is a marker of severe immunosuppression, especially in human immunodeficiency virus (HIV)-positive patients. In multiple myeloma (MM) patients, CMV retinitis has been reported in the post-transplant setting, with an incidence lower than 0.2%, and in patients receiving lenalidomide. Here, we describe the first case of CMV retinitis in myeloma patients following B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor T (BCMA CAR-T) cell therapy. In addition to CMV, the patient developed multiple infections including a mouth ulcer, pneumonia, and fungal enteritis. While the complete remission (CR) status of MM was maintained, he regained a visual acuity of 20/1000 after appropriate ophthalmologic treatment. This single case illustrates the potential of BCMA CAR-T therapy to induce profound humoral immunosuppression, and demonstrates an imperative need for an established standard of monitoring and prophylaxis of post-CAR-T infections.https://www.mdpi.com/1718-7729/29/2/44cytomegalovirus infectionretinitisretinal detachmentchimeric antigen receptor T cellsmultiple myeloma |
| spellingShingle | Cheng Zu Yufeng Xu Yiyun Wang Mingming Zhang Houli Zhao Xiaoyun Fang He Huang Yongxian Hu Cytomegalovirus Retinitis and Retinal Detachment following Chimeric Antigen Receptor T Cell Therapy for Relapsed/Refractory Multiple Myeloma Current Oncology cytomegalovirus infection retinitis retinal detachment chimeric antigen receptor T cells multiple myeloma |
| title | Cytomegalovirus Retinitis and Retinal Detachment following Chimeric Antigen Receptor T Cell Therapy for Relapsed/Refractory Multiple Myeloma |
| title_full | Cytomegalovirus Retinitis and Retinal Detachment following Chimeric Antigen Receptor T Cell Therapy for Relapsed/Refractory Multiple Myeloma |
| title_fullStr | Cytomegalovirus Retinitis and Retinal Detachment following Chimeric Antigen Receptor T Cell Therapy for Relapsed/Refractory Multiple Myeloma |
| title_full_unstemmed | Cytomegalovirus Retinitis and Retinal Detachment following Chimeric Antigen Receptor T Cell Therapy for Relapsed/Refractory Multiple Myeloma |
| title_short | Cytomegalovirus Retinitis and Retinal Detachment following Chimeric Antigen Receptor T Cell Therapy for Relapsed/Refractory Multiple Myeloma |
| title_sort | cytomegalovirus retinitis and retinal detachment following chimeric antigen receptor t cell therapy for relapsed refractory multiple myeloma |
| topic | cytomegalovirus infection retinitis retinal detachment chimeric antigen receptor T cells multiple myeloma |
| url | https://www.mdpi.com/1718-7729/29/2/44 |
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