Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
Mutations in the splicing factor SF3B1 are found in uveal melanoma. Here, Alsafadi et al. use RNA-sequencing data from these cancers and experimental models, and show that mutant SF3B1 promotes alternative branchpoints in a specific gene subset and that the mutant protein gains a new function.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10615 |
| _version_ | 1818839145397616640 |
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| author | Samar Alsafadi Alexandre Houy Aude Battistella Tatiana Popova Michel Wassef Emilie Henry Franck Tirode Angelos Constantinou Sophie Piperno-Neumann Sergio Roman-Roman Martin Dutertre Marc-Henri Stern |
| author_facet | Samar Alsafadi Alexandre Houy Aude Battistella Tatiana Popova Michel Wassef Emilie Henry Franck Tirode Angelos Constantinou Sophie Piperno-Neumann Sergio Roman-Roman Martin Dutertre Marc-Henri Stern |
| author_sort | Samar Alsafadi |
| collection | DOAJ |
| description | Mutations in the splicing factor SF3B1 are found in uveal melanoma. Here, Alsafadi et al. use RNA-sequencing data from these cancers and experimental models, and show that mutant SF3B1 promotes alternative branchpoints in a specific gene subset and that the mutant protein gains a new function. |
| first_indexed | 2024-12-19T03:49:38Z |
| format | Article |
| id | doaj.art-895eb1555d734fbe947b98b9284ba24c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T03:49:38Z |
| publishDate | 2016-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-895eb1555d734fbe947b98b9284ba24c2022-12-21T20:37:01ZengNature PortfolioNature Communications2041-17232016-02-017111210.1038/ncomms10615Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usageSamar Alsafadi0Alexandre Houy1Aude Battistella2Tatiana Popova3Michel Wassef4Emilie Henry5Franck Tirode6Angelos Constantinou7Sophie Piperno-Neumann8Sergio Roman-Roman9Martin Dutertre10Marc-Henri Stern11Department of Genetics and Biology of Cancers, INSERM U830, Institut Curie, PSL Research UniversityDepartment of Genetics and Biology of Cancers, INSERM U830, Institut Curie, PSL Research UniversityDepartment of Genetics and Biology of Cancers, INSERM U830, Institut Curie, PSL Research UniversityDepartment of Genetics and Biology of Cancers, INSERM U830, Institut Curie, PSL Research UniversityDepatment of Developmental Biology and Genetics, CNRS UMR 3215/INSERM U934, Institut Curie, PSL Research UniversityTranslational Research Department, Institut Curie, PSL Research UniversityDepartment of Genetics and Biology of Cancers, INSERM U830, Institut Curie, PSL Research UniversityDepartment of Molecular Bases of Human Diseases, CNRS UPR 1142, IGH-Institute of Human GeneticsDepartment of Medical Oncology, Institut CurieTranslational Research Department, Institut Curie, PSL Research UniversityDepartment of Genotoxic stress and Cancer, CNRS UMR 3348, Institut Curie, PSL Research UniversityDepartment of Genetics and Biology of Cancers, INSERM U830, Institut Curie, PSL Research UniversityMutations in the splicing factor SF3B1 are found in uveal melanoma. Here, Alsafadi et al. use RNA-sequencing data from these cancers and experimental models, and show that mutant SF3B1 promotes alternative branchpoints in a specific gene subset and that the mutant protein gains a new function.https://doi.org/10.1038/ncomms10615 |
| spellingShingle | Samar Alsafadi Alexandre Houy Aude Battistella Tatiana Popova Michel Wassef Emilie Henry Franck Tirode Angelos Constantinou Sophie Piperno-Neumann Sergio Roman-Roman Martin Dutertre Marc-Henri Stern Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage Nature Communications |
| title | Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage |
| title_full | Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage |
| title_fullStr | Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage |
| title_full_unstemmed | Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage |
| title_short | Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage |
| title_sort | cancer associated sf3b1 mutations affect alternative splicing by promoting alternative branchpoint usage |
| url | https://doi.org/10.1038/ncomms10615 |
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