How Should We Classify Kawasaki Disease?
The exact classification of Kawasaki disease (KD) has been debated. Infectious disease specialists have claimed it as an infection with a classic immune responses to an as yet unidentified pathogen that localizes to the coronary arteries. Others have favored an autoreactive hypothesis that KD is tri...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02974/full |
| _version_ | 1818404902540410880 |
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| author | Edoardo Marrani Jane C. Burns Rolando Cimaz |
| author_facet | Edoardo Marrani Jane C. Burns Rolando Cimaz |
| author_sort | Edoardo Marrani |
| collection | DOAJ |
| description | The exact classification of Kawasaki disease (KD) has been debated. Infectious disease specialists have claimed it as an infection with a classic immune responses to an as yet unidentified pathogen that localizes to the coronary arteries. Others have favored an autoreactive hypothesis that KD is triggered by an antigen that shares homology with structures in the vascular wall, and molecular mimicry resulting in an immune response directed to that tissue. Rheumatologists have classified it as a systemic vasculitis, while some immunologists have stressed the robust nature of the innate immune response that causes both systemic inflammation as well as damage to the coronary arterial wall and questioned whether KD falls within the spectrum of autoinflammatory diseases. This review will describe the evidences available up to now regarding these hypotheses. |
| first_indexed | 2024-12-14T08:47:32Z |
| format | Article |
| id | doaj.art-895f9cbfdfa04e5e90e6dc5f6973be1b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T08:47:32Z |
| publishDate | 2018-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-895f9cbfdfa04e5e90e6dc5f6973be1b2022-12-21T23:09:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-12-01910.3389/fimmu.2018.02974415759How Should We Classify Kawasaki Disease?Edoardo Marrani0Jane C. Burns1Rolando Cimaz2Rheumatology Unit, Department of Neurosciences, Psychology, Drug Research and Child Health, Meyer Children's Hospital, University of Florence, Florence, ItalyDepartment of Pediatrics, Kawasaki Disease Research Center, Rady Children's Hospital, University of California, San Diego, San Diego, CA, United StatesRheumatology Unit, Department of Neurosciences, Psychology, Drug Research and Child Health, Meyer Children's Hospital, University of Florence, Florence, ItalyThe exact classification of Kawasaki disease (KD) has been debated. Infectious disease specialists have claimed it as an infection with a classic immune responses to an as yet unidentified pathogen that localizes to the coronary arteries. Others have favored an autoreactive hypothesis that KD is triggered by an antigen that shares homology with structures in the vascular wall, and molecular mimicry resulting in an immune response directed to that tissue. Rheumatologists have classified it as a systemic vasculitis, while some immunologists have stressed the robust nature of the innate immune response that causes both systemic inflammation as well as damage to the coronary arterial wall and questioned whether KD falls within the spectrum of autoinflammatory diseases. This review will describe the evidences available up to now regarding these hypotheses.https://www.frontiersin.org/article/10.3389/fimmu.2018.02974/fullKawasaki diseaseetiopathogenesispediatric vasculitisintravenous immune globulin (IVIg)coronary aneurysm |
| spellingShingle | Edoardo Marrani Jane C. Burns Rolando Cimaz How Should We Classify Kawasaki Disease? Frontiers in Immunology Kawasaki disease etiopathogenesis pediatric vasculitis intravenous immune globulin (IVIg) coronary aneurysm |
| title | How Should We Classify Kawasaki Disease? |
| title_full | How Should We Classify Kawasaki Disease? |
| title_fullStr | How Should We Classify Kawasaki Disease? |
| title_full_unstemmed | How Should We Classify Kawasaki Disease? |
| title_short | How Should We Classify Kawasaki Disease? |
| title_sort | how should we classify kawasaki disease |
| topic | Kawasaki disease etiopathogenesis pediatric vasculitis intravenous immune globulin (IVIg) coronary aneurysm |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02974/full |
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