Molecular Mechanisms of Atopic Dermatitis Pathogenesis
Atopic dermatitis is a chronic, non-infectious inflammatory dermatosis. Acharacteristic feature is persistent itching of the skin. The chronic, relapsing course of the disease, economic burden, and the whole family’s involvement in the treatment process immensely reduce the quality of life of patien...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/8/4130 |
| _version_ | 1797537467446853632 |
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| author | Jowita Sroka-Tomaszewska Magdalena Trzeciak |
| author_facet | Jowita Sroka-Tomaszewska Magdalena Trzeciak |
| author_sort | Jowita Sroka-Tomaszewska |
| collection | DOAJ |
| description | Atopic dermatitis is a chronic, non-infectious inflammatory dermatosis. Acharacteristic feature is persistent itching of the skin. The chronic, relapsing course of the disease, economic burden, and the whole family’s involvement in the treatment process immensely reduce the quality of life of patients and their families. The disease emerges as a social problem by increasing indirect costs, such as visiting a doctor, absenteeism from work and school, and avoiding social interactions. Thepathophysiology of atopic dermatitis is complex and multifactorial. It includes genetic disorders, a defect in the epidermal barrier, an altered immune response, anddisruption of the skin’s microbial balance. The numerous complex changes at thegenetic level and innate and adaptive immunity provide the basis for characterizing the various phenotypes and endotypes of atopic dermatitis. Emerging therapies rely on the action of specific molecules involved in the disease’s pathogenesis. It may be the starting point for the individualization of atopic dermatitis treatment. This paper will try to present some molecular mechanisms of atopic dermatitis and their clinical implications. |
| first_indexed | 2024-03-10T12:15:31Z |
| format | Article |
| id | doaj.art-89604f0528064d86bc83aa86d727312e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:15:31Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-89604f0528064d86bc83aa86d727312e2023-11-21T15:52:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01228413010.3390/ijms22084130Molecular Mechanisms of Atopic Dermatitis PathogenesisJowita Sroka-Tomaszewska0Magdalena Trzeciak1Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-214 Gdańsk, PolandDepartment of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-214 Gdańsk, PolandAtopic dermatitis is a chronic, non-infectious inflammatory dermatosis. Acharacteristic feature is persistent itching of the skin. The chronic, relapsing course of the disease, economic burden, and the whole family’s involvement in the treatment process immensely reduce the quality of life of patients and their families. The disease emerges as a social problem by increasing indirect costs, such as visiting a doctor, absenteeism from work and school, and avoiding social interactions. Thepathophysiology of atopic dermatitis is complex and multifactorial. It includes genetic disorders, a defect in the epidermal barrier, an altered immune response, anddisruption of the skin’s microbial balance. The numerous complex changes at thegenetic level and innate and adaptive immunity provide the basis for characterizing the various phenotypes and endotypes of atopic dermatitis. Emerging therapies rely on the action of specific molecules involved in the disease’s pathogenesis. It may be the starting point for the individualization of atopic dermatitis treatment. This paper will try to present some molecular mechanisms of atopic dermatitis and their clinical implications.https://www.mdpi.com/1422-0067/22/8/4130atopic dermatitisallergic diseasespathogenesisgenetic disordersepidermal barriers defectsimmunological disturbances |
| spellingShingle | Jowita Sroka-Tomaszewska Magdalena Trzeciak Molecular Mechanisms of Atopic Dermatitis Pathogenesis International Journal of Molecular Sciences atopic dermatitis allergic diseases pathogenesis genetic disorders epidermal barriers defects immunological disturbances |
| title | Molecular Mechanisms of Atopic Dermatitis Pathogenesis |
| title_full | Molecular Mechanisms of Atopic Dermatitis Pathogenesis |
| title_fullStr | Molecular Mechanisms of Atopic Dermatitis Pathogenesis |
| title_full_unstemmed | Molecular Mechanisms of Atopic Dermatitis Pathogenesis |
| title_short | Molecular Mechanisms of Atopic Dermatitis Pathogenesis |
| title_sort | molecular mechanisms of atopic dermatitis pathogenesis |
| topic | atopic dermatitis allergic diseases pathogenesis genetic disorders epidermal barriers defects immunological disturbances |
| url | https://www.mdpi.com/1422-0067/22/8/4130 |
| work_keys_str_mv | AT jowitasrokatomaszewska molecularmechanismsofatopicdermatitispathogenesis AT magdalenatrzeciak molecularmechanismsofatopicdermatitispathogenesis |