PREVALENCE OF MTHFR GENE 677C>T POLYMORPHISM IN THE PATIENTS WITH PSORIASIS VULGARIS
The study aimed to investigate the relationship between carriage of 677C>T polymorphism in the gene of methylene tetrahydrofolate reductase (MTHFR) and plaque psoriasis in patients in Bulgaria. We examined the prevalence of MTHFR C677T genotype in patients with psoriasis, as well as the relation...
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| Format: | Article |
| Language: | English |
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Peytchinski Publishing
2021-04-01
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| Series: | Journal of IMAB |
| Subjects: | |
| Online Access: | https://www.journal-imab-bg.org/issues-2021/issue2/2021vol27-issue2-3707-3711.pdf |
| _version_ | 1818715931520532480 |
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| author | Borislav Dimitrov Dimitar Gospodinov Veronika Gincheva Regina Komsa-Penkova |
| author_facet | Borislav Dimitrov Dimitar Gospodinov Veronika Gincheva Regina Komsa-Penkova |
| author_sort | Borislav Dimitrov |
| collection | DOAJ |
| description | The study aimed to investigate the relationship between carriage of 677C>T polymorphism in the gene of methylene tetrahydrofolate reductase (MTHFR) and plaque psoriasis in patients in Bulgaria.
We examined the prevalence of MTHFR C677T genotype in patients with psoriasis, as well as the relationship of the polymorphism with disease severity. Our study covered63 patients with psoriasis and 98psoriasis-free control subjects from northern Bulgaria. MTHFR677C>T genotype was verified by the PCR-RFLP method. There was no significant difference between carriage of TT genotype among the patients and controls: 12.7% versus 10.8 %in controls, OR 1.203, (CI 95% 0465-3.175), p>0.05 respectively. There was a higher PASI score in patients, carriers of TT genotype of MTHFR polymorphism 677C>T than in non-carriers, 28.18versus 24.87 respectively, but not significant.
Conclusion: Carriage of TT genotype of MTHFR polymorphism 677C>T was not associated with Psoriasis Vulgaris in the northern Bulgarian population when compared to healthy controls. |
| first_indexed | 2024-12-17T19:11:12Z |
| format | Article |
| id | doaj.art-89608ef2f95741b4930502e077c24e0c |
| institution | Directory Open Access Journal |
| issn | 1312-773X |
| language | English |
| last_indexed | 2024-12-17T19:11:12Z |
| publishDate | 2021-04-01 |
| publisher | Peytchinski Publishing |
| record_format | Article |
| series | Journal of IMAB |
| spelling | doaj.art-89608ef2f95741b4930502e077c24e0c2022-12-21T21:35:52ZengPeytchinski PublishingJournal of IMAB1312-773X2021-04-012723707371110.5272/jimab.2021272.3707PREVALENCE OF MTHFR GENE 677C>T POLYMORPHISM IN THE PATIENTS WITH PSORIASIS VULGARISBorislav Dimitrov0https://orcid.org/0000-0001-5198-0641Dimitar Gospodinov1https://orcid.org/0000-0001-6800-4671Veronika Gincheva2https://orcid.org/0000-0001-8150-3555Regina Komsa-Penkova3https://orcid.org/0000-0002-1349-9555Department of Chemistry and Biochemistry, Faculty of Pharmacy, University of Medicine, Pleven, Bulgaria.Department of Dermatology, Venereology and Allergology, Medical University - Pleven, Bulgaria.Department of Dermatology, Venereology and Allergology, Medical University - Pleven, Bulgaria.Department of Chemistry and Biochemistry, Faculty of Pharmacy, University of Medicine, Pleven, Bulgaria.The study aimed to investigate the relationship between carriage of 677C>T polymorphism in the gene of methylene tetrahydrofolate reductase (MTHFR) and plaque psoriasis in patients in Bulgaria. We examined the prevalence of MTHFR C677T genotype in patients with psoriasis, as well as the relationship of the polymorphism with disease severity. Our study covered63 patients with psoriasis and 98psoriasis-free control subjects from northern Bulgaria. MTHFR677C>T genotype was verified by the PCR-RFLP method. There was no significant difference between carriage of TT genotype among the patients and controls: 12.7% versus 10.8 %in controls, OR 1.203, (CI 95% 0465-3.175), p>0.05 respectively. There was a higher PASI score in patients, carriers of TT genotype of MTHFR polymorphism 677C>T than in non-carriers, 28.18versus 24.87 respectively, but not significant. Conclusion: Carriage of TT genotype of MTHFR polymorphism 677C>T was not associated with Psoriasis Vulgaris in the northern Bulgarian population when compared to healthy controls.https://www.journal-imab-bg.org/issues-2021/issue2/2021vol27-issue2-3707-3711.pdfpsoriasismthfr polymorphism 677c>tpasibulgarian population |
| spellingShingle | Borislav Dimitrov Dimitar Gospodinov Veronika Gincheva Regina Komsa-Penkova PREVALENCE OF MTHFR GENE 677C>T POLYMORPHISM IN THE PATIENTS WITH PSORIASIS VULGARIS Journal of IMAB psoriasis mthfr polymorphism 677c>t pasi bulgarian population |
| title | PREVALENCE OF MTHFR GENE 677C>T POLYMORPHISM IN THE PATIENTS WITH PSORIASIS VULGARIS |
| title_full | PREVALENCE OF MTHFR GENE 677C>T POLYMORPHISM IN THE PATIENTS WITH PSORIASIS VULGARIS |
| title_fullStr | PREVALENCE OF MTHFR GENE 677C>T POLYMORPHISM IN THE PATIENTS WITH PSORIASIS VULGARIS |
| title_full_unstemmed | PREVALENCE OF MTHFR GENE 677C>T POLYMORPHISM IN THE PATIENTS WITH PSORIASIS VULGARIS |
| title_short | PREVALENCE OF MTHFR GENE 677C>T POLYMORPHISM IN THE PATIENTS WITH PSORIASIS VULGARIS |
| title_sort | prevalence of mthfr gene 677c t polymorphism in the patients with psoriasis vulgaris |
| topic | psoriasis mthfr polymorphism 677c>t pasi bulgarian population |
| url | https://www.journal-imab-bg.org/issues-2021/issue2/2021vol27-issue2-3707-3711.pdf |
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