SH3YL1 Protein Predicts Renal Outcomes in Patients with Type 2 Diabetes
NADPH oxidase (NOX)-derived oxidative stress is an important factor in renal progression, with NOX4 being the predominant NOX in the kidney. Recently, Src homology 3 (SH3) domain-containing YSC84-like 1 (SH3YL1) was reported to be a regulator of NOX4. In this study, we tested whether the SH3YL1 prot...
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MDPI AG
2023-04-01
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| Online Access: | https://www.mdpi.com/2075-1729/13/4/963 |
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| author | Sang Youb Han Seung Hyun Han Jung Yeon Ghee Jin Joo Cha Young Sun Kang Dae Ryong Cha |
| author_facet | Sang Youb Han Seung Hyun Han Jung Yeon Ghee Jin Joo Cha Young Sun Kang Dae Ryong Cha |
| author_sort | Sang Youb Han |
| collection | DOAJ |
| description | NADPH oxidase (NOX)-derived oxidative stress is an important factor in renal progression, with NOX4 being the predominant NOX in the kidney. Recently, Src homology 3 (SH3) domain-containing YSC84-like 1 (SH3YL1) was reported to be a regulator of NOX4. In this study, we tested whether the SH3YL1 protein could predict 3-year renal outcomes in patients with type 2 diabetes. A total of 131 patients with type 2 diabetes were enrolled in this study. Renal events were defined as a 15% decline in the estimated glomerular filtration rate (eGFR) from the baseline, the initiation of renal replacement therapy, or death during the 3 years. The levels of the urinary SH3YL1-to-creatinine ratio (USCR) were significantly different among the five stages of chronic kidney disease (CKD) and the three groups, based on albuminuria levels. The USCR levels showed a significant negative correlation with eGFR and a positive correlation with the urinary albumin-to-creatinine ratio (UACR). Plasma SH3YL1 levels were significantly correlated with UACR. The highest tertile group of USCR and plasma SH3YL1 had a significantly lower probability of renal event-free survival. Furthermore, the highest tertile group of USCR showed a significant association with the incidence of renal events after full adjustment: adjusted hazard ratio (4.636: 95% confidence interval, 1.416–15.181, <i>p</i> = 0.011). This study suggests that SH3YL1 is a new diagnostic biomarker for renal outcomes in patients with type 2 diabetes. |
| first_indexed | 2024-03-11T04:50:08Z |
| format | Article |
| id | doaj.art-89628234c9c84b79ad1015747bb9a7bc |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T04:50:08Z |
| publishDate | 2023-04-01 |
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| record_format | Article |
| series | Life |
| spelling | doaj.art-89628234c9c84b79ad1015747bb9a7bc2023-11-17T20:06:08ZengMDPI AGLife2075-17292023-04-0113496310.3390/life13040963SH3YL1 Protein Predicts Renal Outcomes in Patients with Type 2 DiabetesSang Youb Han0Seung Hyun Han1Jung Yeon Ghee2Jin Joo Cha3Young Sun Kang4Dae Ryong Cha5Department of Internal Medicine, Inje University, Ilsan-Paik Hospital, Goyang 10380, Republic of KoreaDepartment of Internal Medicine, Inje University, Ilsan-Paik Hospital, Goyang 10380, Republic of KoreaDepartment of Internal Medicine, Korea University, Ansan Hospital, Ansan 15368, Republic of KoreaDepartment of Internal Medicine, Korea University, Ansan Hospital, Ansan 15368, Republic of KoreaDepartment of Internal Medicine, Korea University, Ansan Hospital, Ansan 15368, Republic of KoreaDepartment of Internal Medicine, Korea University, Ansan Hospital, Ansan 15368, Republic of KoreaNADPH oxidase (NOX)-derived oxidative stress is an important factor in renal progression, with NOX4 being the predominant NOX in the kidney. Recently, Src homology 3 (SH3) domain-containing YSC84-like 1 (SH3YL1) was reported to be a regulator of NOX4. In this study, we tested whether the SH3YL1 protein could predict 3-year renal outcomes in patients with type 2 diabetes. A total of 131 patients with type 2 diabetes were enrolled in this study. Renal events were defined as a 15% decline in the estimated glomerular filtration rate (eGFR) from the baseline, the initiation of renal replacement therapy, or death during the 3 years. The levels of the urinary SH3YL1-to-creatinine ratio (USCR) were significantly different among the five stages of chronic kidney disease (CKD) and the three groups, based on albuminuria levels. The USCR levels showed a significant negative correlation with eGFR and a positive correlation with the urinary albumin-to-creatinine ratio (UACR). Plasma SH3YL1 levels were significantly correlated with UACR. The highest tertile group of USCR and plasma SH3YL1 had a significantly lower probability of renal event-free survival. Furthermore, the highest tertile group of USCR showed a significant association with the incidence of renal events after full adjustment: adjusted hazard ratio (4.636: 95% confidence interval, 1.416–15.181, <i>p</i> = 0.011). This study suggests that SH3YL1 is a new diagnostic biomarker for renal outcomes in patients with type 2 diabetes.https://www.mdpi.com/2075-1729/13/4/963SH3YL1diabeteskidneyNOX4biomarker |
| spellingShingle | Sang Youb Han Seung Hyun Han Jung Yeon Ghee Jin Joo Cha Young Sun Kang Dae Ryong Cha SH3YL1 Protein Predicts Renal Outcomes in Patients with Type 2 Diabetes Life SH3YL1 diabetes kidney NOX4 biomarker |
| title | SH3YL1 Protein Predicts Renal Outcomes in Patients with Type 2 Diabetes |
| title_full | SH3YL1 Protein Predicts Renal Outcomes in Patients with Type 2 Diabetes |
| title_fullStr | SH3YL1 Protein Predicts Renal Outcomes in Patients with Type 2 Diabetes |
| title_full_unstemmed | SH3YL1 Protein Predicts Renal Outcomes in Patients with Type 2 Diabetes |
| title_short | SH3YL1 Protein Predicts Renal Outcomes in Patients with Type 2 Diabetes |
| title_sort | sh3yl1 protein predicts renal outcomes in patients with type 2 diabetes |
| topic | SH3YL1 diabetes kidney NOX4 biomarker |
| url | https://www.mdpi.com/2075-1729/13/4/963 |
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