Innovative Drugs to Target Renal Inflammation in Sepsis: Alkaline Phosphatase

Innovative Drugs to Target Renal Inflammation in Sepsis: Alkaline Phosphatase

Sepsis-related mortality roughly doubles when acute kidney injury (AKI) occurs and end-stage renal disease is more common in sepsis-associated AKI survivors. So far, no licensed treatment for the prevention of AKI is available, however the data on alkaline phosphatase (AP) is promising and might cha...

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Bibliographic Details
Main Authors: Femke Hümmeke-Oppers, Pleun Hemelaar, Peter Pickkers
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Pharmacology
Subjects:
acute kidney injury
recombinant alkaline phosphatase
sepsis
septic shock
sepsis-associated acute kidney injury
chronic kidney disease
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00919/full

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