Nanoparticulate Drug Delivery Strategies to Address Intestinal Cytochrome P450 CYP3A4 Metabolism towards Personalized Medicine

Nanoparticulate Drug Delivery Strategies to Address Intestinal Cytochrome P450 CYP3A4 Metabolism towards Personalized Medicine

Drug dosing in clinical practice, which determines optimal efficacy, toxicity or ineffectiveness, is critical to patients’ outcomes. However, many orally administered therapeutic drugs are susceptible to biotransformation by a group of important oxidative enzymes, known as cytochrome P450s (CYPs). I...

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Bibliographic Details
Main Authors: Rui Xue Zhang, Ken Dong, Zhigao Wang, Ruimin Miao, Weijia Lu, Xiao Yu Wu
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceutics
Subjects:
oral drug delivery
drug-drug interaction
bioavailability
CYP3A4
BDDCS
gastrointestinal tract
Online Access:https://www.mdpi.com/1999-4923/13/8/1261

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