Using shRNA experiments to validate gene regulatory networks

Using shRNA experiments to validate gene regulatory networks

Quantitative validation of gene regulatory networks (GRNs) inferred from observational expression data is a difficult task usually involving time intensive and costly laboratory experiments. We were able to show that gene knock-down experiments can be used to quantitatively assess the quality of lar...

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Bibliographic Details
Main Authors: Catharina Olsen, Kathleen Fleming, Niall Prendergast, Renee Rubio, Frank Emmert-Streib, Gianluca Bontempi, John Quackenbush, Benjamin Haibe-Kains
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Genomics Data
Subjects:
Knock-down
Gene expression
Microarray
Colon cancer
shRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2213596015000288

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