Evusheld Prophylaxis Improves Social Interactions, Anxiety, Depression, Agoraphobia, and Quality of Life in Blood Cancer Patients
Evusheld is a combination injection of tixagevimab and cilgavimab and is indicated for the pre-exposure prophylaxis of COVID-19 in adults and adolescents aged 12 years and older. Its use has been advocated for immunosuppressed individuals, such as blood cancer patients, although uptake varies signif...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | COVID |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-8112/3/5/48 |
| _version_ | 1827741705046065152 |
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| author | Annabel M. Follows Charlotte Clark Catherine Dye Lorraine King Gail Skillings Grace Byrne Vicki Tinkler George A. Follows |
| author_facet | Annabel M. Follows Charlotte Clark Catherine Dye Lorraine King Gail Skillings Grace Byrne Vicki Tinkler George A. Follows |
| author_sort | Annabel M. Follows |
| collection | DOAJ |
| description | Evusheld is a combination injection of tixagevimab and cilgavimab and is indicated for the pre-exposure prophylaxis of COVID-19 in adults and adolescents aged 12 years and older. Its use has been advocated for immunosuppressed individuals, such as blood cancer patients, although uptake varies significantly between countries. Despite extensive use internationally, there has been limited analysis of potential psychological benefits that vulnerable patients might gain from receiving this prophylactic medication. In this study we have quantified four key psychological health parameters in blood cancer patients who received Evusheld (EQ5D-3L quality of life score, DSM5 Agoraphobia score, Duke’s Social Support Index and the hospital anxiety and depression score) and compared their responses with a control group of patients who did not receive Evusheld. We show that patients who opted for treatment had higher baseline markers of psychological stress and ill-health compared with non-treated individuals but that treatment with Evusheld significantly improved the psychological health of recipients and increased the level of physical social/work interactions over that of control patients. Although there are limitations with this small study, the findings strongly suggest that Evusheld prophylaxis can provide significant psychological benefits for vulnerable blood cancer patients who have significant anxiety about COVID-19 infection. |
| first_indexed | 2024-03-11T03:49:52Z |
| format | Article |
| id | doaj.art-89697cc386a14ddeb4c44eb799df2a26 |
| institution | Directory Open Access Journal |
| issn | 2673-8112 |
| language | English |
| last_indexed | 2024-03-11T03:49:52Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | COVID |
| spelling | doaj.art-89697cc386a14ddeb4c44eb799df2a262023-11-18T00:58:35ZengMDPI AGCOVID2673-81122023-04-013566467010.3390/covid3050048Evusheld Prophylaxis Improves Social Interactions, Anxiety, Depression, Agoraphobia, and Quality of Life in Blood Cancer PatientsAnnabel M. Follows0Charlotte Clark1Catherine Dye2Lorraine King3Gail Skillings4Grace Byrne5Vicki Tinkler6George A. Follows7School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0SP, UKGenesis Care, The Oaks, Fordham Rd., Newmarket, Cambridge CB8 7XN, UKGenesis Care, The Oaks, Fordham Rd., Newmarket, Cambridge CB8 7XN, UKGenesis Care, The Oaks, Fordham Rd., Newmarket, Cambridge CB8 7XN, UKGenesis Care, The Oaks, Fordham Rd., Newmarket, Cambridge CB8 7XN, UKGenesis Care, The Oaks, Fordham Rd., Newmarket, Cambridge CB8 7XN, UKGenesis Care, The Oaks, Fordham Rd., Newmarket, Cambridge CB8 7XN, UKGenesis Care, The Oaks, Fordham Rd., Newmarket, Cambridge CB8 7XN, UKEvusheld is a combination injection of tixagevimab and cilgavimab and is indicated for the pre-exposure prophylaxis of COVID-19 in adults and adolescents aged 12 years and older. Its use has been advocated for immunosuppressed individuals, such as blood cancer patients, although uptake varies significantly between countries. Despite extensive use internationally, there has been limited analysis of potential psychological benefits that vulnerable patients might gain from receiving this prophylactic medication. In this study we have quantified four key psychological health parameters in blood cancer patients who received Evusheld (EQ5D-3L quality of life score, DSM5 Agoraphobia score, Duke’s Social Support Index and the hospital anxiety and depression score) and compared their responses with a control group of patients who did not receive Evusheld. We show that patients who opted for treatment had higher baseline markers of psychological stress and ill-health compared with non-treated individuals but that treatment with Evusheld significantly improved the psychological health of recipients and increased the level of physical social/work interactions over that of control patients. Although there are limitations with this small study, the findings strongly suggest that Evusheld prophylaxis can provide significant psychological benefits for vulnerable blood cancer patients who have significant anxiety about COVID-19 infection.https://www.mdpi.com/2673-8112/3/5/48COVID-19EvusheldEQ5D-3Lblood cancer |
| spellingShingle | Annabel M. Follows Charlotte Clark Catherine Dye Lorraine King Gail Skillings Grace Byrne Vicki Tinkler George A. Follows Evusheld Prophylaxis Improves Social Interactions, Anxiety, Depression, Agoraphobia, and Quality of Life in Blood Cancer Patients COVID COVID-19 Evusheld EQ5D-3L blood cancer |
| title | Evusheld Prophylaxis Improves Social Interactions, Anxiety, Depression, Agoraphobia, and Quality of Life in Blood Cancer Patients |
| title_full | Evusheld Prophylaxis Improves Social Interactions, Anxiety, Depression, Agoraphobia, and Quality of Life in Blood Cancer Patients |
| title_fullStr | Evusheld Prophylaxis Improves Social Interactions, Anxiety, Depression, Agoraphobia, and Quality of Life in Blood Cancer Patients |
| title_full_unstemmed | Evusheld Prophylaxis Improves Social Interactions, Anxiety, Depression, Agoraphobia, and Quality of Life in Blood Cancer Patients |
| title_short | Evusheld Prophylaxis Improves Social Interactions, Anxiety, Depression, Agoraphobia, and Quality of Life in Blood Cancer Patients |
| title_sort | evusheld prophylaxis improves social interactions anxiety depression agoraphobia and quality of life in blood cancer patients |
| topic | COVID-19 Evusheld EQ5D-3L blood cancer |
| url | https://www.mdpi.com/2673-8112/3/5/48 |
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