Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials
Introduction: Numerous approaches have been assigned to treat dyslipidemia (DLP). Turmeric/curcumin have been widely investigated with this regard. In the current study, we explored the effect of curcumin/turmeric supplementation on lipid profile. Methods: Online databases were searched up to Octobe...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Complementary Therapies in Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0965229923000420 |
| _version_ | 1797802931451330560 |
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| author | Mohammad Jafar Dehzad Hamid Ghalandari Mohammad Reza Amini Moein Askarpour |
| author_facet | Mohammad Jafar Dehzad Hamid Ghalandari Mohammad Reza Amini Moein Askarpour |
| author_sort | Mohammad Jafar Dehzad |
| collection | DOAJ |
| description | Introduction: Numerous approaches have been assigned to treat dyslipidemia (DLP). Turmeric/curcumin have been widely investigated with this regard. In the current study, we explored the effect of curcumin/turmeric supplementation on lipid profile. Methods: Online databases were searched up to October 2022. The outcomes included triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), apolipoprotein B (Apo-B), and apolipoprotein A (Apo-A). We used the Cochrane quality assessment tool to evaluate the risk of bias. The effect sizes were estimated as weighted mean difference (WMD) and 95% confidence intervals (CIs). Results: Out of 4182 articles retrieved from the initial search, 64 randomized clinical trials (RCTs) were included in the study. Between-study heterogeneity was significant. Meta-analysis showed that turmeric/curcumin supplementation exerts statistically significant improvements on blood levels of TC (WMD = −3.99 mg/dL; 95% CI = −5.33, −2.65), TG (WMD = −6.69 mg/dL; 95% CI = −7.93, −5.45), LDL-c (WMD = −4.89 mg/dL; 95% CI = −5.92, −3.87), and HDL-c (WMD = 1.80 mg/dL; 95% CI = 1.43, 2.17). However, turmeric/curcumin supplementation was not associated with improvements in blood levels of Apo-A or Apo-B. The studies did not thoroughly address the issues of potency, purity, or consumption with other foods. Conclusion: Turmeric/curcumin supplementation seems to be effective in improving blood levels of TC, TG, LDL-c, and HDL-c; but may not be capable of improving their pertinent apolipoproteins. Since the evidence was assessed to be low and very low concerning the outcomes, these findings should be dealt with caution. |
| first_indexed | 2024-03-13T05:13:10Z |
| format | Article |
| id | doaj.art-896ab25b35cc4481bc5ad422d76b2ae8 |
| institution | Directory Open Access Journal |
| issn | 0965-2299 |
| language | English |
| last_indexed | 2024-03-13T05:13:10Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Complementary Therapies in Medicine |
| spelling | doaj.art-896ab25b35cc4481bc5ad422d76b2ae82023-06-16T05:08:28ZengElsevierComplementary Therapies in Medicine0965-22992023-08-0175102955Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trialsMohammad Jafar Dehzad0Hamid Ghalandari1Mohammad Reza Amini2Moein Askarpour3Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, IranStudent Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; Correspondence to: Moein Askarpour, Department of clinical Nutrition, School of Nutrition Sciences and Dietetics, Shiraz University of Medical Sciences, Shiraz, Iran.Introduction: Numerous approaches have been assigned to treat dyslipidemia (DLP). Turmeric/curcumin have been widely investigated with this regard. In the current study, we explored the effect of curcumin/turmeric supplementation on lipid profile. Methods: Online databases were searched up to October 2022. The outcomes included triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), apolipoprotein B (Apo-B), and apolipoprotein A (Apo-A). We used the Cochrane quality assessment tool to evaluate the risk of bias. The effect sizes were estimated as weighted mean difference (WMD) and 95% confidence intervals (CIs). Results: Out of 4182 articles retrieved from the initial search, 64 randomized clinical trials (RCTs) were included in the study. Between-study heterogeneity was significant. Meta-analysis showed that turmeric/curcumin supplementation exerts statistically significant improvements on blood levels of TC (WMD = −3.99 mg/dL; 95% CI = −5.33, −2.65), TG (WMD = −6.69 mg/dL; 95% CI = −7.93, −5.45), LDL-c (WMD = −4.89 mg/dL; 95% CI = −5.92, −3.87), and HDL-c (WMD = 1.80 mg/dL; 95% CI = 1.43, 2.17). However, turmeric/curcumin supplementation was not associated with improvements in blood levels of Apo-A or Apo-B. The studies did not thoroughly address the issues of potency, purity, or consumption with other foods. Conclusion: Turmeric/curcumin supplementation seems to be effective in improving blood levels of TC, TG, LDL-c, and HDL-c; but may not be capable of improving their pertinent apolipoproteins. Since the evidence was assessed to be low and very low concerning the outcomes, these findings should be dealt with caution.http://www.sciencedirect.com/science/article/pii/S0965229923000420CurcuminTurmericRCTsMeta-analysisLipid profile |
| spellingShingle | Mohammad Jafar Dehzad Hamid Ghalandari Mohammad Reza Amini Moein Askarpour Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials Complementary Therapies in Medicine Curcumin Turmeric RCTs Meta-analysis Lipid profile |
| title | Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials |
| title_full | Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials |
| title_fullStr | Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials |
| title_full_unstemmed | Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials |
| title_short | Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials |
| title_sort | effects of curcumin turmeric supplementation on lipid profile a grade assessed systematic review and dose response meta analysis of randomized controlled trials |
| topic | Curcumin Turmeric RCTs Meta-analysis Lipid profile |
| url | http://www.sciencedirect.com/science/article/pii/S0965229923000420 |
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