Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.

Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.

Chronic intestinal parasite infection is a major global health problem, but mechanisms that promote chronicity are poorly understood. Here we describe a novel cellular and molecular pathway involved in the development of chronic intestinal parasite infection. We show that, early during development o...

Full description

Bibliographic Details
Main Authors: John J Worthington, Joanna E Klementowicz, Sayema Rahman, Beata I Czajkowska, Catherine Smedley, Herman Waldmann, Tim Sparwasser, Richard K Grencis, Mark A Travis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3789784?pdf=render

Similar Items

Similar Items