Cancer Stem Cells, <i>Quo Vadis</i>? The Notch Signaling Pathway in Tumor Initiation and Progression
The Notch signaling pathway regulates cell proliferation, cytodifferentiation and cell fate decisions in both embryonic and adult life. Several aspects of stem cell maintenance are dependent from the functionality and fine tuning of the Notch pathway. In cancer, Notch is specifically involved in pre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/8/1879 |
| _version_ | 1797558949542625280 |
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| author | Christian T. Meisel Cristina Porcheri Thimios A. Mitsiadis |
| author_facet | Christian T. Meisel Cristina Porcheri Thimios A. Mitsiadis |
| author_sort | Christian T. Meisel |
| collection | DOAJ |
| description | The Notch signaling pathway regulates cell proliferation, cytodifferentiation and cell fate decisions in both embryonic and adult life. Several aspects of stem cell maintenance are dependent from the functionality and fine tuning of the Notch pathway. In cancer, Notch is specifically involved in preserving self-renewal and amplification of cancer stem cells, supporting the formation, spread and recurrence of the tumor. As the function of Notch signaling is context dependent, we here provide an overview of its activity in a variety of tumors, focusing mostly on its role in the maintenance of the undifferentiated subset of cancer cells. Finally, we analyze the potential of molecules of the Notch pathway as diagnostic and therapeutic tools against the various cancers. |
| first_indexed | 2024-03-10T17:37:39Z |
| format | Article |
| id | doaj.art-896d2c5e360e404685396805aa77deb0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T17:37:39Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-896d2c5e360e404685396805aa77deb02023-11-20T09:47:29ZengMDPI AGCells2073-44092020-08-0198187910.3390/cells9081879Cancer Stem Cells, <i>Quo Vadis</i>? The Notch Signaling Pathway in Tumor Initiation and ProgressionChristian T. Meisel0Cristina Porcheri1Thimios A. Mitsiadis2Institute of Oral Biology, University of Zurich, Plattenstrasse 11, 8032 Zurich, SwitzerlandInstitute of Oral Biology, University of Zurich, Plattenstrasse 11, 8032 Zurich, SwitzerlandInstitute of Oral Biology, University of Zurich, Plattenstrasse 11, 8032 Zurich, SwitzerlandThe Notch signaling pathway regulates cell proliferation, cytodifferentiation and cell fate decisions in both embryonic and adult life. Several aspects of stem cell maintenance are dependent from the functionality and fine tuning of the Notch pathway. In cancer, Notch is specifically involved in preserving self-renewal and amplification of cancer stem cells, supporting the formation, spread and recurrence of the tumor. As the function of Notch signaling is context dependent, we here provide an overview of its activity in a variety of tumors, focusing mostly on its role in the maintenance of the undifferentiated subset of cancer cells. Finally, we analyze the potential of molecules of the Notch pathway as diagnostic and therapeutic tools against the various cancers.https://www.mdpi.com/2073-4409/9/8/1879Notch signaling pathwaycancerstem cellscancer stem cellsradioresistancechemoresistance |
| spellingShingle | Christian T. Meisel Cristina Porcheri Thimios A. Mitsiadis Cancer Stem Cells, <i>Quo Vadis</i>? The Notch Signaling Pathway in Tumor Initiation and Progression Cells Notch signaling pathway cancer stem cells cancer stem cells radioresistance chemoresistance |
| title | Cancer Stem Cells, <i>Quo Vadis</i>? The Notch Signaling Pathway in Tumor Initiation and Progression |
| title_full | Cancer Stem Cells, <i>Quo Vadis</i>? The Notch Signaling Pathway in Tumor Initiation and Progression |
| title_fullStr | Cancer Stem Cells, <i>Quo Vadis</i>? The Notch Signaling Pathway in Tumor Initiation and Progression |
| title_full_unstemmed | Cancer Stem Cells, <i>Quo Vadis</i>? The Notch Signaling Pathway in Tumor Initiation and Progression |
| title_short | Cancer Stem Cells, <i>Quo Vadis</i>? The Notch Signaling Pathway in Tumor Initiation and Progression |
| title_sort | cancer stem cells i quo vadis i the notch signaling pathway in tumor initiation and progression |
| topic | Notch signaling pathway cancer stem cells cancer stem cells radioresistance chemoresistance |
| url | https://www.mdpi.com/2073-4409/9/8/1879 |
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