Obesity as a Risk Factor for Venous Thromboembolism Recurrence: A Systematic Review
<i>Background and Objectives:</i> Venous thromboembolism (VTE) encompasses Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE). The duration of anticoagulant therapy following a VTE event partly relies on the risk of recurrent VTE which depends on the clinical setting where VTE occu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/9/1290 |
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| author | Pinelopi Ntinopoulou Erato Ntinopoulou Ioanna V. Papathanasiou Evangelos C. Fradelos Ourania Kotsiou Nikolaos Roussas Dimitrios G. Raptis Konstantinos I. Gourgoulianis Foteini Malli |
| author_facet | Pinelopi Ntinopoulou Erato Ntinopoulou Ioanna V. Papathanasiou Evangelos C. Fradelos Ourania Kotsiou Nikolaos Roussas Dimitrios G. Raptis Konstantinos I. Gourgoulianis Foteini Malli |
| author_sort | Pinelopi Ntinopoulou |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Venous thromboembolism (VTE) encompasses Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE). The duration of anticoagulant therapy following a VTE event partly relies on the risk of recurrent VTE which depends on the clinical setting where VTE occurred and the VTE risk factors present. Obesity is considered a minor risk factor and studies in the literature have provided conflicting results on whether obesity influences the development of recurrences. The aim of the present study is to assess the effect of obesity on VTE recurrence in patients that suffered from a previous VTE event. <i>Materials and Methods:</i> We conducted systematic research for English language studies in Medline, Scopus and ProQuest databases in order to identify publications that assess the risk of VTE recurrence in obesity. Inclusion criteria were: 1. Diagnosis of VTE, 2. Definition of obesity as a body mass index ≥30 kg/m<sup>2</sup>, 3. Report of the risk of obesity on VTE recurrence, 4. Adult human population. We did not include case reports, review studies or studies that assessed other forms of thrombosis and/or used other definitions of obesity. We used the Newcastle-Ottawa scale to address the quality of the studies. <i>Results:</i> Twenty studies were included in the analysis, of which 11 where prospective cohort studies, 6 were retrospective cohort studies, 1 was a cross-sectional study, and 2 were post-hoc analysis of randomized clinical trials. Obesity was significantly associated with recurrences in 9 studies and in 3 of them the association was significant only in females. <i>Conclusions:</i> There is heterogeneity between the studies both in their design and results, therefore the effect of obesity on VTE recurrence cannot be adequately estimated. Future randomized clinical studies with appropriately selected population are needed in order to streamline the effect of obesity on VTE recurrence. |
| first_indexed | 2024-03-09T23:12:48Z |
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| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T23:12:48Z |
| publishDate | 2022-09-01 |
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| series | Medicina |
| spelling | doaj.art-896dc15e3f6e408ab199296ac6bd187c2023-11-23T17:41:08ZengMDPI AGMedicina1010-660X1648-91442022-09-01589129010.3390/medicina58091290Obesity as a Risk Factor for Venous Thromboembolism Recurrence: A Systematic ReviewPinelopi Ntinopoulou0Erato Ntinopoulou1Ioanna V. Papathanasiou2Evangelos C. Fradelos3Ourania Kotsiou4Nikolaos Roussas5Dimitrios G. Raptis6Konstantinos I. Gourgoulianis7Foteini Malli8Department of Cardiology, Laikon General Hospital, 11527 Athens, GreeceDepartment of Pediatrics, Yverdon-les-Bains Hospital, 1400 Yverdon-les-Bains, SwitzerlandCommunity Nursing Lab, Faculty of Nursing, University of Thessaly, 41500 Larissa, GreeceCommunity Nursing Lab, Faculty of Nursing, University of Thessaly, 41500 Larissa, GreeceFaculty of Nursing, School of Health Sciences, University of Thessaly, 41500 Larissa, GreeceDepartment of Vascular Surgery, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, 41500 Larissa, GreeceRespiratory Disorders Lab, Faculty of Nursing, University of Thessaly, 41500 Larissa, GreeceRespiratory Medicine Department, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, 41500 Larissa, GreeceRespiratory Disorders Lab, Faculty of Nursing, University of Thessaly, 41500 Larissa, Greece<i>Background and Objectives:</i> Venous thromboembolism (VTE) encompasses Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE). The duration of anticoagulant therapy following a VTE event partly relies on the risk of recurrent VTE which depends on the clinical setting where VTE occurred and the VTE risk factors present. Obesity is considered a minor risk factor and studies in the literature have provided conflicting results on whether obesity influences the development of recurrences. The aim of the present study is to assess the effect of obesity on VTE recurrence in patients that suffered from a previous VTE event. <i>Materials and Methods:</i> We conducted systematic research for English language studies in Medline, Scopus and ProQuest databases in order to identify publications that assess the risk of VTE recurrence in obesity. Inclusion criteria were: 1. Diagnosis of VTE, 2. Definition of obesity as a body mass index ≥30 kg/m<sup>2</sup>, 3. Report of the risk of obesity on VTE recurrence, 4. Adult human population. We did not include case reports, review studies or studies that assessed other forms of thrombosis and/or used other definitions of obesity. We used the Newcastle-Ottawa scale to address the quality of the studies. <i>Results:</i> Twenty studies were included in the analysis, of which 11 where prospective cohort studies, 6 were retrospective cohort studies, 1 was a cross-sectional study, and 2 were post-hoc analysis of randomized clinical trials. Obesity was significantly associated with recurrences in 9 studies and in 3 of them the association was significant only in females. <i>Conclusions:</i> There is heterogeneity between the studies both in their design and results, therefore the effect of obesity on VTE recurrence cannot be adequately estimated. Future randomized clinical studies with appropriately selected population are needed in order to streamline the effect of obesity on VTE recurrence.https://www.mdpi.com/1648-9144/58/9/1290obesityvenous thromboembolismdeep venous thrombosispulmonary embolismrecurrencerisk factor |
| spellingShingle | Pinelopi Ntinopoulou Erato Ntinopoulou Ioanna V. Papathanasiou Evangelos C. Fradelos Ourania Kotsiou Nikolaos Roussas Dimitrios G. Raptis Konstantinos I. Gourgoulianis Foteini Malli Obesity as a Risk Factor for Venous Thromboembolism Recurrence: A Systematic Review Medicina obesity venous thromboembolism deep venous thrombosis pulmonary embolism recurrence risk factor |
| title | Obesity as a Risk Factor for Venous Thromboembolism Recurrence: A Systematic Review |
| title_full | Obesity as a Risk Factor for Venous Thromboembolism Recurrence: A Systematic Review |
| title_fullStr | Obesity as a Risk Factor for Venous Thromboembolism Recurrence: A Systematic Review |
| title_full_unstemmed | Obesity as a Risk Factor for Venous Thromboembolism Recurrence: A Systematic Review |
| title_short | Obesity as a Risk Factor for Venous Thromboembolism Recurrence: A Systematic Review |
| title_sort | obesity as a risk factor for venous thromboembolism recurrence a systematic review |
| topic | obesity venous thromboembolism deep venous thrombosis pulmonary embolism recurrence risk factor |
| url | https://www.mdpi.com/1648-9144/58/9/1290 |
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