Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis
In vitro models to study the role of host genetics in the response to chlamydial infection are limited. Here, Yeung et al. show that macrophages derived from human induced pluripotent stem cells (which can be genetically manipulated) support chlamydial infection and can be used for this purpose.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15013 |
| _version_ | 1818750482607243264 |
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| author | Amy T. Y. Yeung Christine Hale Amy H. Lee Erin E. Gill Wendy Bushell David Parry-Smith David Goulding Derek Pickard Theodoros Roumeliotis Jyoti Choudhary Nick Thomson William C. Skarnes Gordon Dougan Robert E. W. Hancock |
| author_facet | Amy T. Y. Yeung Christine Hale Amy H. Lee Erin E. Gill Wendy Bushell David Parry-Smith David Goulding Derek Pickard Theodoros Roumeliotis Jyoti Choudhary Nick Thomson William C. Skarnes Gordon Dougan Robert E. W. Hancock |
| author_sort | Amy T. Y. Yeung |
| collection | DOAJ |
| description | In vitro models to study the role of host genetics in the response to chlamydial infection are limited. Here, Yeung et al. show that macrophages derived from human induced pluripotent stem cells (which can be genetically manipulated) support chlamydial infection and can be used for this purpose. |
| first_indexed | 2024-12-18T04:20:23Z |
| format | Article |
| id | doaj.art-896e301f7f054800992a554f5dfd59b5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:20:23Z |
| publishDate | 2017-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-896e301f7f054800992a554f5dfd59b52022-12-21T21:21:15ZengNature PortfolioNature Communications2041-17232017-04-018111210.1038/ncomms15013Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesisAmy T. Y. Yeung0Christine Hale1Amy H. Lee2Erin E. Gill3Wendy Bushell4David Parry-Smith5David Goulding6Derek Pickard7Theodoros Roumeliotis8Jyoti Choudhary9Nick Thomson10William C. Skarnes11Gordon Dougan12Robert E. W. Hancock13Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusWellcome Trust Sanger Institute, Wellcome Trust Genome CampusCentre for Microbial Diseases and Immunity Research, University of British ColumbiaCentre for Microbial Diseases and Immunity Research, University of British ColumbiaWellcome Trust Sanger Institute, Wellcome Trust Genome CampusWellcome Trust Sanger Institute, Wellcome Trust Genome CampusWellcome Trust Sanger Institute, Wellcome Trust Genome CampusWellcome Trust Sanger Institute, Wellcome Trust Genome CampusWellcome Trust Sanger Institute, Wellcome Trust Genome CampusWellcome Trust Sanger Institute, Wellcome Trust Genome CampusWellcome Trust Sanger Institute, Wellcome Trust Genome CampusWellcome Trust Sanger Institute, Wellcome Trust Genome CampusWellcome Trust Sanger Institute, Wellcome Trust Genome CampusWellcome Trust Sanger Institute, Wellcome Trust Genome CampusIn vitro models to study the role of host genetics in the response to chlamydial infection are limited. Here, Yeung et al. show that macrophages derived from human induced pluripotent stem cells (which can be genetically manipulated) support chlamydial infection and can be used for this purpose.https://doi.org/10.1038/ncomms15013 |
| spellingShingle | Amy T. Y. Yeung Christine Hale Amy H. Lee Erin E. Gill Wendy Bushell David Parry-Smith David Goulding Derek Pickard Theodoros Roumeliotis Jyoti Choudhary Nick Thomson William C. Skarnes Gordon Dougan Robert E. W. Hancock Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis Nature Communications |
| title | Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis |
| title_full | Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis |
| title_fullStr | Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis |
| title_full_unstemmed | Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis |
| title_short | Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis |
| title_sort | exploiting induced pluripotent stem cell derived macrophages to unravel host factors influencing chlamydia trachomatis pathogenesis |
| url | https://doi.org/10.1038/ncomms15013 |
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