The Relationship between Primary Gross Tumor Volume and Tumor Response of Locally Advanced Rectal Cancer: pGTV as a More Accurate Tumor Size Indicator
Purpose: To identify the clinical predictive factors of tumor response and to evaluate the significance of primary gross tumor volume (pGTV), obtained from radiotherapy planning, in predicting tumor response. Materials and Methods: We retrospectively analyzed data of consecutive locally advanced rec...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-02-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2019.1615153 |
| _version_ | 1797684680997208064 |
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| author | Wenxue Liu Yuqiang Li Hong Zhu Qian Pei Fengbo Tan Xiangping Song Zhongyi Zhou Yuan Zhou Dan Wang Haiping Pei |
| author_facet | Wenxue Liu Yuqiang Li Hong Zhu Qian Pei Fengbo Tan Xiangping Song Zhongyi Zhou Yuan Zhou Dan Wang Haiping Pei |
| author_sort | Wenxue Liu |
| collection | DOAJ |
| description | Purpose: To identify the clinical predictive factors of tumor response and to evaluate the significance of primary gross tumor volume (pGTV), obtained from radiotherapy planning, in predicting tumor response. Materials and Methods: We retrospectively analyzed data of consecutive locally advanced rectal cancer (LARC) patients who were treated with neoadjuvant chemoradiotherapy (nCRT) followed by radical surgery at our institution between March 2009 and December 2017. We identify independent predictors of tumor response to nCRT by statistical analysis. Disease-free survival (DFS) starting from the time of surgery was calculated by the Kaplan–Meier method, and log-rank tests were performed to compare DFS between patients with superior and inferior tumor response. Results: Overall, 185 LARC patients received nCRT, of whom 89 (48.11%) achieved superior tumor response. Diminutive pGTV (p = 0.038) and distance from the anal verge (DAV) (p = 0.006) were independent predictive factors of superior tumor response. Meanwhile, pGTV can be regarded as an independent predictor of pathologic complete response (pCR) (p = 0.036). The log-rank test revealed that DFS was longer in the diminutive pGTV group than in the giant pGTV group (p = 0.001). Conclusions: pGTV, as a measure of tumor size, is not only an important prognostic indicator but also an independent predictive factor of tumor response, even pCR. |
| first_indexed | 2024-03-12T00:33:12Z |
| format | Article |
| id | doaj.art-896fce05761148e6889551e1e0ccb4d3 |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:33:12Z |
| publishDate | 2021-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-896fce05761148e6889551e1e0ccb4d32023-09-15T10:07:30ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532021-02-0134218119010.1080/08941939.2019.16151531615153The Relationship between Primary Gross Tumor Volume and Tumor Response of Locally Advanced Rectal Cancer: pGTV as a More Accurate Tumor Size IndicatorWenxue Liu0Yuqiang Li1Hong Zhu2Qian Pei3Fengbo Tan4Xiangping Song5Zhongyi Zhou6Yuan Zhou7Dan Wang8Haiping Pei9Central South UniversityCentral South UniversityCentral South UniversityCentral South UniversityCentral South UniversityCentral South UniversityCentral South UniversityCentral South UniversityCentral South UniversityCentral South UniversityPurpose: To identify the clinical predictive factors of tumor response and to evaluate the significance of primary gross tumor volume (pGTV), obtained from radiotherapy planning, in predicting tumor response. Materials and Methods: We retrospectively analyzed data of consecutive locally advanced rectal cancer (LARC) patients who were treated with neoadjuvant chemoradiotherapy (nCRT) followed by radical surgery at our institution between March 2009 and December 2017. We identify independent predictors of tumor response to nCRT by statistical analysis. Disease-free survival (DFS) starting from the time of surgery was calculated by the Kaplan–Meier method, and log-rank tests were performed to compare DFS between patients with superior and inferior tumor response. Results: Overall, 185 LARC patients received nCRT, of whom 89 (48.11%) achieved superior tumor response. Diminutive pGTV (p = 0.038) and distance from the anal verge (DAV) (p = 0.006) were independent predictive factors of superior tumor response. Meanwhile, pGTV can be regarded as an independent predictor of pathologic complete response (pCR) (p = 0.036). The log-rank test revealed that DFS was longer in the diminutive pGTV group than in the giant pGTV group (p = 0.001). Conclusions: pGTV, as a measure of tumor size, is not only an important prognostic indicator but also an independent predictive factor of tumor response, even pCR.http://dx.doi.org/10.1080/08941939.2019.1615153primary gross tumor volumetumor responseneoadjuvant chemoradiotherapylocally advanced rectal cancertumor regression grade |
| spellingShingle | Wenxue Liu Yuqiang Li Hong Zhu Qian Pei Fengbo Tan Xiangping Song Zhongyi Zhou Yuan Zhou Dan Wang Haiping Pei The Relationship between Primary Gross Tumor Volume and Tumor Response of Locally Advanced Rectal Cancer: pGTV as a More Accurate Tumor Size Indicator Journal of Investigative Surgery primary gross tumor volume tumor response neoadjuvant chemoradiotherapy locally advanced rectal cancer tumor regression grade |
| title | The Relationship between Primary Gross Tumor Volume and Tumor Response of Locally Advanced Rectal Cancer: pGTV as a More Accurate Tumor Size Indicator |
| title_full | The Relationship between Primary Gross Tumor Volume and Tumor Response of Locally Advanced Rectal Cancer: pGTV as a More Accurate Tumor Size Indicator |
| title_fullStr | The Relationship between Primary Gross Tumor Volume and Tumor Response of Locally Advanced Rectal Cancer: pGTV as a More Accurate Tumor Size Indicator |
| title_full_unstemmed | The Relationship between Primary Gross Tumor Volume and Tumor Response of Locally Advanced Rectal Cancer: pGTV as a More Accurate Tumor Size Indicator |
| title_short | The Relationship between Primary Gross Tumor Volume and Tumor Response of Locally Advanced Rectal Cancer: pGTV as a More Accurate Tumor Size Indicator |
| title_sort | relationship between primary gross tumor volume and tumor response of locally advanced rectal cancer pgtv as a more accurate tumor size indicator |
| topic | primary gross tumor volume tumor response neoadjuvant chemoradiotherapy locally advanced rectal cancer tumor regression grade |
| url | http://dx.doi.org/10.1080/08941939.2019.1615153 |
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