How osteogenic is dexamethasone?—effect of the corticosteroid on the osteogenesis, extracellular matrix, and secretion of osteoclastogenic factors of jaw periosteum-derived mesenchymal stem/stromal cells

How osteogenic is dexamethasone?—effect of the corticosteroid on the osteogenesis, extracellular matrix, and secretion of osteoclastogenic factors of jaw periosteum-derived mesenchymal stem/stromal cells

Dexamethasone (dexa) is commonly used to stimulate osteogenic differentiation of mesenchymal stem/stromal cells (MSCs) in vitro. However, it is paradoxical that glucocorticoids (GCs) such as dexa lead to bone loss and increased fracture risk in patients undergoing glucocorticoid therapy, causing glu...

Full description

Bibliographic Details
Main Authors: Felix Umrath, Achim Pfeifer, Wanjing Cen, Marina Danalache, Siegmar Reinert, Dorothea Alexander, Andreas Naros
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
dexamethasone
osteogenic differentiation
mesenchymal stem/stromal cells
periosteum
osteoclast
extracellular matrix
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.953516/full

Similar Items

Similar Items