Negative symptoms and social and occupational functioning differentiate systematic paraphrenia from schizophrenia: results from a cross-sectional study
Introduction Kraepelin’s systematic paraphrenia (SP) has been historically used to identify a group of patients in the psychosis-spectrum with good global functioning and reduced impairment in volition and emotions. Objectives Cross-sectional study comparing a group of patients with SP with anothe...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822020521/type/journal_article |
| _version_ | 1797616861555195904 |
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| author | L.A. Fernandes B. Trancas T. Maia N. Borja Santos |
| author_facet | L.A. Fernandes B. Trancas T. Maia N. Borja Santos |
| author_sort | L.A. Fernandes |
| collection | DOAJ |
| description |
Introduction
Kraepelin’s systematic paraphrenia (SP) has been historically used to identify a group of patients in the psychosis-spectrum with good global functioning and reduced impairment in volition and emotions.
Objectives
Cross-sectional study comparing a group of patients with SP with another with schizophrenia (SZ).
Methods
We consecutively recruited SP cases from a single centre. SZ cases were selected to match those in the SP group in terms of age and sex. We diagnosed SP using the Munro Criteria and SZ using ICD-10. We collected standard sociodemographic and clinical data. All patients were under follow-up in a community mental health team at the time of the study. We used PANSS total score (PANSS-TS) to assess disease severity and its subscales to evaluate positive (PANSS-P) and negative (PANSS-N) symptoms, and general psychopathology (PANSS-GP). We applied SOFAS to assess social and occupational functioning.
Results
We recruited 32 patients, 16 with a diagnosis of SP and 16 with a diagnosis of SZ. The two groups did not differ in terms of sociodemographic data. SP cases showed lower values for PANSS-TS (SP: mean=51.63±12.49; SZ=77.76±14.12; p<0.001), PANSS-NS (SP: mean=15.50±5.97; SZ: mean=26.06±5.39; p<0.001), and PANSS-GP (SP: mean=24.31±5.51; SZ: mean=37.13±5.62; p<0.001). Groups did not differ in terms of positive symptoms. SOFAS scores were significantly higher in SP (SP: median=68, interquartile range (IQR)=19; SZ: median=41, IQR=24; p<0.01). PNSS-NS negatively correlated with SOFAS only in the SP group (r=-0.716; p=0.002).
Conclusions
SP differs from SZ in negative symptoms and social and occupational functioning. These findings suggest clinical features can differentiate SP from SZ.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:47:23Z |
| format | Article |
| id | doaj.art-89717316a37143b780c789d2d1952a08 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:47:23Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-89717316a37143b780c789d2d1952a082023-11-17T05:07:25ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S794S79410.1192/j.eurpsy.2022.2052Negative symptoms and social and occupational functioning differentiate systematic paraphrenia from schizophrenia: results from a cross-sectional studyL.A. Fernandes0B. Trancas1T. Maia2N. Borja Santos3Hospital Prof. Doutor Fernando Fonseca EPE, Psychiatry, Amadora, PortugalHospital Prof. Doutor Fernando Fonseca EPE, Psychiatry, Amadora, PortugalHospital Prof. Doutor Fernando Fonseca EPE, Psychiatry, Amadora, PortugalHospital Prof. Doutor Fernando Fonseca EPE, Psychiatry, Amadora, Portugal Introduction Kraepelin’s systematic paraphrenia (SP) has been historically used to identify a group of patients in the psychosis-spectrum with good global functioning and reduced impairment in volition and emotions. Objectives Cross-sectional study comparing a group of patients with SP with another with schizophrenia (SZ). Methods We consecutively recruited SP cases from a single centre. SZ cases were selected to match those in the SP group in terms of age and sex. We diagnosed SP using the Munro Criteria and SZ using ICD-10. We collected standard sociodemographic and clinical data. All patients were under follow-up in a community mental health team at the time of the study. We used PANSS total score (PANSS-TS) to assess disease severity and its subscales to evaluate positive (PANSS-P) and negative (PANSS-N) symptoms, and general psychopathology (PANSS-GP). We applied SOFAS to assess social and occupational functioning. Results We recruited 32 patients, 16 with a diagnosis of SP and 16 with a diagnosis of SZ. The two groups did not differ in terms of sociodemographic data. SP cases showed lower values for PANSS-TS (SP: mean=51.63±12.49; SZ=77.76±14.12; p<0.001), PANSS-NS (SP: mean=15.50±5.97; SZ: mean=26.06±5.39; p<0.001), and PANSS-GP (SP: mean=24.31±5.51; SZ: mean=37.13±5.62; p<0.001). Groups did not differ in terms of positive symptoms. SOFAS scores were significantly higher in SP (SP: median=68, interquartile range (IQR)=19; SZ: median=41, IQR=24; p<0.01). PNSS-NS negatively correlated with SOFAS only in the SP group (r=-0.716; p=0.002). Conclusions SP differs from SZ in negative symptoms and social and occupational functioning. These findings suggest clinical features can differentiate SP from SZ. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822020521/type/journal_articleparaphreniaschizophrénianegative symtpomsPsychosis |
| spellingShingle | L.A. Fernandes B. Trancas T. Maia N. Borja Santos Negative symptoms and social and occupational functioning differentiate systematic paraphrenia from schizophrenia: results from a cross-sectional study European Psychiatry paraphrenia schizophrénia negative symtpoms Psychosis |
| title | Negative symptoms and social and occupational functioning differentiate systematic paraphrenia from schizophrenia: results from a cross-sectional study |
| title_full | Negative symptoms and social and occupational functioning differentiate systematic paraphrenia from schizophrenia: results from a cross-sectional study |
| title_fullStr | Negative symptoms and social and occupational functioning differentiate systematic paraphrenia from schizophrenia: results from a cross-sectional study |
| title_full_unstemmed | Negative symptoms and social and occupational functioning differentiate systematic paraphrenia from schizophrenia: results from a cross-sectional study |
| title_short | Negative symptoms and social and occupational functioning differentiate systematic paraphrenia from schizophrenia: results from a cross-sectional study |
| title_sort | negative symptoms and social and occupational functioning differentiate systematic paraphrenia from schizophrenia results from a cross sectional study |
| topic | paraphrenia schizophrénia negative symtpoms Psychosis |
| url | https://www.cambridge.org/core/product/identifier/S0924933822020521/type/journal_article |
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