Polyphenol-rich peach (Prunus persica L.) by-product exerts a greater beneficial effect than dietary fiber-rich by-product on insulin resistance and hepatic steatosis in obese rats
Peach juice by-product (PJBP) can prevent complications of obesity due to its high content of polyphenols and dietary fiber. This study aimed to evaluate the effect of a polyphenol-rich (PR-PJBP) and a dietary fiber-rich (DFR-PJBP) peach juice by-product on insulin resistance and hepatic steatosis i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464618300975 |
| _version_ | 1819292718907523072 |
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| author | Sarahí Rodríguez-González Iza F. Pérez-Ramírez Diana M. Amaya-Cruz Marco A. Gallegos-Corona Minerva Ramos-Gomez Ofelia Mora Rosalía Reynoso-Camacho |
| author_facet | Sarahí Rodríguez-González Iza F. Pérez-Ramírez Diana M. Amaya-Cruz Marco A. Gallegos-Corona Minerva Ramos-Gomez Ofelia Mora Rosalía Reynoso-Camacho |
| author_sort | Sarahí Rodríguez-González |
| collection | DOAJ |
| description | Peach juice by-product (PJBP) can prevent complications of obesity due to its high content of polyphenols and dietary fiber. This study aimed to evaluate the effect of a polyphenol-rich (PR-PJBP) and a dietary fiber-rich (DFR-PJBP) peach juice by-product on insulin resistance and hepatic steatosis in obese rats. Animals were fed with high fat and fructose diet (HFF) and supplemented with PR-PJBP and DFR-PJBP for eighteen weeks. PR-PJBP produced the greatest hypoglycemic effect by improving insulin resistance, increasing hepatic glycogen content, and decreasing hepatic PEPCK activity. Likewise, PR-PJBP decreased serum triglycerides levels, ameliorating hepatic steatosis, decreasing hepatic expression of Srebp1 and Fasn, and increasing hepatic Cpt1 expression. These results suggest that polyphenols from PJBP exert a greater beneficial effect on obesity-related complications than dietary fiber. These effects were associated with caffeoylquinic, p-coumaroylquinic and 4-feruloylquinic acids, and kaempferol derivatives. PR-PJBP could be used as an ingredient for the elaboration of functional foods. |
| first_indexed | 2024-12-24T03:59:00Z |
| format | Article |
| id | doaj.art-8974506a535a44f9a111e64e2080f91b |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T03:59:00Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-8974506a535a44f9a111e64e2080f91b2022-12-21T17:16:21ZengElsevierJournal of Functional Foods1756-46462018-06-01455866Polyphenol-rich peach (Prunus persica L.) by-product exerts a greater beneficial effect than dietary fiber-rich by-product on insulin resistance and hepatic steatosis in obese ratsSarahí Rodríguez-González0Iza F. Pérez-Ramírez1Diana M. Amaya-Cruz2Marco A. Gallegos-Corona3Minerva Ramos-Gomez4Ofelia Mora5Rosalía Reynoso-Camacho6Facultad de Química, Universidad Autónoma de Querétaro, C.U., Cerro de las Campanas S/N, Querétaro 76010, Qro., MexicoFacultad de Química, Universidad Autónoma de Querétaro, C.U., Cerro de las Campanas S/N, Querétaro 76010, Qro., MexicoFacultad de Química, Universidad Autónoma de Querétaro, C.U., Cerro de las Campanas S/N, Querétaro 76010, Qro., MexicoFacultad de Medicina, Universidad Autónoma de Querétaro, Prados de La Capilla 200, Querétaro 76176, Qro., MexicoFacultad de Química, Universidad Autónoma de Querétaro, C.U., Cerro de las Campanas S/N, Querétaro 76010, Qro., MexicoFacultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de de México, Blvd. Juriquilla 3001, Juriquilla 76230, Querétaro, MexicoFacultad de Química, Universidad Autónoma de Querétaro, C.U., Cerro de las Campanas S/N, Querétaro 76010, Qro., Mexico; Corresponding author.Peach juice by-product (PJBP) can prevent complications of obesity due to its high content of polyphenols and dietary fiber. This study aimed to evaluate the effect of a polyphenol-rich (PR-PJBP) and a dietary fiber-rich (DFR-PJBP) peach juice by-product on insulin resistance and hepatic steatosis in obese rats. Animals were fed with high fat and fructose diet (HFF) and supplemented with PR-PJBP and DFR-PJBP for eighteen weeks. PR-PJBP produced the greatest hypoglycemic effect by improving insulin resistance, increasing hepatic glycogen content, and decreasing hepatic PEPCK activity. Likewise, PR-PJBP decreased serum triglycerides levels, ameliorating hepatic steatosis, decreasing hepatic expression of Srebp1 and Fasn, and increasing hepatic Cpt1 expression. These results suggest that polyphenols from PJBP exert a greater beneficial effect on obesity-related complications than dietary fiber. These effects were associated with caffeoylquinic, p-coumaroylquinic and 4-feruloylquinic acids, and kaempferol derivatives. PR-PJBP could be used as an ingredient for the elaboration of functional foods.http://www.sciencedirect.com/science/article/pii/S1756464618300975PeachBy-productPolyphenolsDietary fiberHepatic steatosisInsulin resistance |
| spellingShingle | Sarahí Rodríguez-González Iza F. Pérez-Ramírez Diana M. Amaya-Cruz Marco A. Gallegos-Corona Minerva Ramos-Gomez Ofelia Mora Rosalía Reynoso-Camacho Polyphenol-rich peach (Prunus persica L.) by-product exerts a greater beneficial effect than dietary fiber-rich by-product on insulin resistance and hepatic steatosis in obese rats Journal of Functional Foods Peach By-product Polyphenols Dietary fiber Hepatic steatosis Insulin resistance |
| title | Polyphenol-rich peach (Prunus persica L.) by-product exerts a greater beneficial effect than dietary fiber-rich by-product on insulin resistance and hepatic steatosis in obese rats |
| title_full | Polyphenol-rich peach (Prunus persica L.) by-product exerts a greater beneficial effect than dietary fiber-rich by-product on insulin resistance and hepatic steatosis in obese rats |
| title_fullStr | Polyphenol-rich peach (Prunus persica L.) by-product exerts a greater beneficial effect than dietary fiber-rich by-product on insulin resistance and hepatic steatosis in obese rats |
| title_full_unstemmed | Polyphenol-rich peach (Prunus persica L.) by-product exerts a greater beneficial effect than dietary fiber-rich by-product on insulin resistance and hepatic steatosis in obese rats |
| title_short | Polyphenol-rich peach (Prunus persica L.) by-product exerts a greater beneficial effect than dietary fiber-rich by-product on insulin resistance and hepatic steatosis in obese rats |
| title_sort | polyphenol rich peach prunus persica l by product exerts a greater beneficial effect than dietary fiber rich by product on insulin resistance and hepatic steatosis in obese rats |
| topic | Peach By-product Polyphenols Dietary fiber Hepatic steatosis Insulin resistance |
| url | http://www.sciencedirect.com/science/article/pii/S1756464618300975 |
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