Lapatinib-induced acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) is a pustular eruption, mainly drug induced often accompanied by fever and neutrophilic leukocytosis presenting as scarlatiniform erythema over the flexures evolving into numerous tiny non follicular pustules. We present a case report of a 56-year ol...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2010-01-01
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| Series: | Indian Dermatology Online Journal |
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| Online Access: | http://www.idoj.in/article.asp?issn=2229-5178;year=2010;volume=1;issue=1;spage=14;epage=17;aulast=Lakshmi |
| _version_ | 1818855544925978624 |
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| author | Chembolli Lakshmi Suma Pillai C R Srinivas |
| author_facet | Chembolli Lakshmi Suma Pillai C R Srinivas |
| author_sort | Chembolli Lakshmi |
| collection | DOAJ |
| description | Acute generalized exanthematous pustulosis (AGEP) is a pustular eruption, mainly drug induced often accompanied by fever and neutrophilic leukocytosis presenting as scarlatiniform erythema over the flexures evolving into numerous tiny non follicular pustules. We present a case report of a 56-year old woman, who had undergone mastectomy, treated with lapatinib for metastatic disease, and who presented with multiple erythematous papules and plaques with peripheral pustules. She also developed painful pyogenic granuloma-like lesions over the pulp of toe and over the proximal nail folds.All the lesions subsided following withdrawal of lapatinib. Although AGEP has been reported with imatinib (a multikinase inhibitor), there have been no reports of serious reactions with lapatinib, an EGFR inhibitor. This case could represent the first case report of AGEP to the EGFR inhibitor, lapatinib. |
| first_indexed | 2024-12-19T08:10:18Z |
| format | Article |
| id | doaj.art-8974e3cce9d94429b843c2d9425b24de |
| institution | Directory Open Access Journal |
| issn | 2229-5178 |
| language | English |
| last_indexed | 2024-12-19T08:10:18Z |
| publishDate | 2010-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Dermatology Online Journal |
| spelling | doaj.art-8974e3cce9d94429b843c2d9425b24de2022-12-21T20:29:40ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782010-01-0111141710.4103/2229-5178.73251Lapatinib-induced acute generalized exanthematous pustulosisChembolli LakshmiSuma PillaiC R SrinivasAcute generalized exanthematous pustulosis (AGEP) is a pustular eruption, mainly drug induced often accompanied by fever and neutrophilic leukocytosis presenting as scarlatiniform erythema over the flexures evolving into numerous tiny non follicular pustules. We present a case report of a 56-year old woman, who had undergone mastectomy, treated with lapatinib for metastatic disease, and who presented with multiple erythematous papules and plaques with peripheral pustules. She also developed painful pyogenic granuloma-like lesions over the pulp of toe and over the proximal nail folds.All the lesions subsided following withdrawal of lapatinib. Although AGEP has been reported with imatinib (a multikinase inhibitor), there have been no reports of serious reactions with lapatinib, an EGFR inhibitor. This case could represent the first case report of AGEP to the EGFR inhibitor, lapatinib.http://www.idoj.in/article.asp?issn=2229-5178;year=2010;volume=1;issue=1;spage=14;epage=17;aulast=LakshmiLapatinibacute generalized exanthematous pustulosisepidermal growth factor receptor inhibitorpyogenic granuloma-like lesion |
| spellingShingle | Chembolli Lakshmi Suma Pillai C R Srinivas Lapatinib-induced acute generalized exanthematous pustulosis Indian Dermatology Online Journal Lapatinib acute generalized exanthematous pustulosis epidermal growth factor receptor inhibitor pyogenic granuloma-like lesion |
| title | Lapatinib-induced acute generalized exanthematous pustulosis |
| title_full | Lapatinib-induced acute generalized exanthematous pustulosis |
| title_fullStr | Lapatinib-induced acute generalized exanthematous pustulosis |
| title_full_unstemmed | Lapatinib-induced acute generalized exanthematous pustulosis |
| title_short | Lapatinib-induced acute generalized exanthematous pustulosis |
| title_sort | lapatinib induced acute generalized exanthematous pustulosis |
| topic | Lapatinib acute generalized exanthematous pustulosis epidermal growth factor receptor inhibitor pyogenic granuloma-like lesion |
| url | http://www.idoj.in/article.asp?issn=2229-5178;year=2010;volume=1;issue=1;spage=14;epage=17;aulast=Lakshmi |
| work_keys_str_mv | AT chembollilakshmi lapatinibinducedacutegeneralizedexanthematouspustulosis AT sumapillai lapatinibinducedacutegeneralizedexanthematouspustulosis AT crsrinivas lapatinibinducedacutegeneralizedexanthematouspustulosis |