Association of physical activity with dementia and cognitive decline in UK Biobank
Abstract INTRODUCTION There is a lack of studies on the association between specific physical activity (PA) types and dementia. We examined the association of leisure time physical activity (LTPA), occupational physical activity (OPA), and sedentary lifestyle with dementia risk and cognitive decline...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12476 |
| _version_ | 1827805702206259200 |
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| author | Xiangyuan Huang Chuen Seng Tan Nagaendran Kandiah Saima Hilal |
| author_facet | Xiangyuan Huang Chuen Seng Tan Nagaendran Kandiah Saima Hilal |
| author_sort | Xiangyuan Huang |
| collection | DOAJ |
| description | Abstract INTRODUCTION There is a lack of studies on the association between specific physical activity (PA) types and dementia. We examined the association of leisure time physical activity (LTPA), occupational physical activity (OPA), and sedentary lifestyle with dementia risk and cognitive decline using the UK‐Biobank study. METHODS Baseline PA was collected using questionnaires. A total of 502,481 dementia‐free participants were recruited in 2006–2010 and followed for 10 years until the end of 2020 for the ascertainment of dementia. Associations of PA with incident dementia and cognitive decline were examined. RESULTS Higher levels of LTPA and OPA and lower levels of sedentary hours were associated with lower dementia risk. The fifth quintiles of LTPA (hazard ratio [HR] = 0.53, 95% confidence interval [CI]: 0.43‐0.67) and OPA (HR = 0.68, 95% CI:0.51‐0.90) had lower dementia risk, whereas the fifth quintile of sedentary lifestyle had higher dementia risk (HR = 1.23, 95% CI:1.08‐1.41). DISCUSSION Our findings suggest the promotion of an active lifestyle suggested to be preventive of dementia risk. This research has been conducted using the UK Biobank Resource under Application Number 71022. |
| first_indexed | 2024-03-11T21:30:01Z |
| format | Article |
| id | doaj.art-897528cd5a9141cbb73187d13b9eff0e |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-03-11T21:30:01Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-897528cd5a9141cbb73187d13b9eff0e2023-09-27T11:20:33ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292023-07-01153n/an/a10.1002/dad2.12476Association of physical activity with dementia and cognitive decline in UK BiobankXiangyuan Huang0Chuen Seng Tan1Nagaendran Kandiah2Saima Hilal3Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore SingaporeSaw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore SingaporeDementia Research Centre Lee Kong Chian School of Medicine Singapore SingaporeSaw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore SingaporeAbstract INTRODUCTION There is a lack of studies on the association between specific physical activity (PA) types and dementia. We examined the association of leisure time physical activity (LTPA), occupational physical activity (OPA), and sedentary lifestyle with dementia risk and cognitive decline using the UK‐Biobank study. METHODS Baseline PA was collected using questionnaires. A total of 502,481 dementia‐free participants were recruited in 2006–2010 and followed for 10 years until the end of 2020 for the ascertainment of dementia. Associations of PA with incident dementia and cognitive decline were examined. RESULTS Higher levels of LTPA and OPA and lower levels of sedentary hours were associated with lower dementia risk. The fifth quintiles of LTPA (hazard ratio [HR] = 0.53, 95% confidence interval [CI]: 0.43‐0.67) and OPA (HR = 0.68, 95% CI:0.51‐0.90) had lower dementia risk, whereas the fifth quintile of sedentary lifestyle had higher dementia risk (HR = 1.23, 95% CI:1.08‐1.41). DISCUSSION Our findings suggest the promotion of an active lifestyle suggested to be preventive of dementia risk. This research has been conducted using the UK Biobank Resource under Application Number 71022.https://doi.org/10.1002/dad2.12476cognitiondementialifestylephysical activity |
| spellingShingle | Xiangyuan Huang Chuen Seng Tan Nagaendran Kandiah Saima Hilal Association of physical activity with dementia and cognitive decline in UK Biobank Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring cognition dementia lifestyle physical activity |
| title | Association of physical activity with dementia and cognitive decline in UK Biobank |
| title_full | Association of physical activity with dementia and cognitive decline in UK Biobank |
| title_fullStr | Association of physical activity with dementia and cognitive decline in UK Biobank |
| title_full_unstemmed | Association of physical activity with dementia and cognitive decline in UK Biobank |
| title_short | Association of physical activity with dementia and cognitive decline in UK Biobank |
| title_sort | association of physical activity with dementia and cognitive decline in uk biobank |
| topic | cognition dementia lifestyle physical activity |
| url | https://doi.org/10.1002/dad2.12476 |
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