IL-40: A New B Cell-Associated Cytokine Up-Regulated in Rheumatoid Arthritis Decreases Following the Rituximab Therapy and Correlates With Disease Activity, Autoantibodies, and NETosis

IL-40: A New B Cell-Associated Cytokine Up-Regulated in Rheumatoid Arthritis Decreases Following the Rituximab Therapy and Correlates With Disease Activity, Autoantibodies, and NETosis

BackgroundInterleukin 40 (IL-40) is a newly identified B cell-associated cytokine implicated in humoral immune responses and B cell homeostasis. As B cells play a pivotal role in autoimmunity, we investigated the function of IL-40 in rheumatoid arthritis (RA).MethodsIL-40 expression was determined i...

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Bibliographic Details
Main Authors: Adela Navrátilová, Lucie Andrés Cerezo, Hana Hulejová, Viktor Bečvář, Michal Tomčík, Martin Komarc, David Veigl, Dana Tegzová, Jakub Závada, Marta Olejárová, Karel Pavelka, Jiří Vencovský, Ladislav Šenolt
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
interleukin-40
rheumatoid arthritis
autoantibodies
disease activity
B cells
NETosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.745523/full

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