The Ethnopharmacological Uses, Metabolite Diversity, and Bioactivity of <i>Rhaponticum uniflorum</i> (<i>Leuzea uniflora</i>): A Comprehensive Review
<i>Rhaponticum uniflorum</i> (L.) DC. (<i>syn</i>. <i>Leuzea uniflora</i> (L.) Holub) is a plant species of the Compositae (Asteraceae) family that is widely used in Asian traditional medicines in China, Siberia, and Mongolia as an anti-inflammatory and stimulant...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/11/1720 |
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| author | Daniil N. Olennikov |
| author_facet | Daniil N. Olennikov |
| author_sort | Daniil N. Olennikov |
| collection | DOAJ |
| description | <i>Rhaponticum uniflorum</i> (L.) DC. (<i>syn</i>. <i>Leuzea uniflora</i> (L.) Holub) is a plant species of the Compositae (Asteraceae) family that is widely used in Asian traditional medicines in China, Siberia, and Mongolia as an anti-inflammatory and stimulant remedy. Currently, <i>R. uniflorum</i> is of scientific interest to chemists, biologists, and pharmacologists, and this review includes information from the scientific literature from 1991 to 2022. The study of the chemodiversity of <i>R. uniflorum</i> revealed the presence of 225 compounds, including sesquiterpenes, ecdysteroids, triterpenes, sterols, thiophenes, hydroxycinnamates, flavonoids, lignans, nucleosides and vitamins, alkanes, fatty acids, and carbohydrates. The most studied groups of substances are phenolics (76 compounds) and triterpenoids (69 compounds). Information on the methods of chromatographic analysis of selected compounds, as well as on the quantitative content of some components in various organs of <i>R. uniflorum</i>, is summarized in this work. It has been shown that the extracts and some compounds of <i>R. uniflorum</i> have a wide range of biological activities, including anti-inflammatory, antitumor, immunostimulatory, anxiolytic, stress-protective, actoprotective, antihypoxic, anabolic, hepatoprotective, inhibition of PPARγ receptors, anti-atherosclerotic, and hypolipidemic. Published research on the metabolites and bioactivity of <i>R. uniflorum</i> does not include clinical studies of extracts and pure compounds; therefore, an accurate study of this traditional medicinal plant is needed. |
| first_indexed | 2024-03-09T18:27:31Z |
| format | Article |
| id | doaj.art-89771137b50a43829713af0be7dcc8c1 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T18:27:31Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-89771137b50a43829713af0be7dcc8c12023-11-24T07:48:20ZengMDPI AGBiomolecules2218-273X2022-11-011211172010.3390/biom12111720The Ethnopharmacological Uses, Metabolite Diversity, and Bioactivity of <i>Rhaponticum uniflorum</i> (<i>Leuzea uniflora</i>): A Comprehensive ReviewDaniil N. Olennikov0Laboratory of Biomedical Research, Institute of General and Experimental Biology, Siberian Division, Russian Academy of Science, Sakh’yanovoy Street 6, 670047 Ulan-Ude, Russia<i>Rhaponticum uniflorum</i> (L.) DC. (<i>syn</i>. <i>Leuzea uniflora</i> (L.) Holub) is a plant species of the Compositae (Asteraceae) family that is widely used in Asian traditional medicines in China, Siberia, and Mongolia as an anti-inflammatory and stimulant remedy. Currently, <i>R. uniflorum</i> is of scientific interest to chemists, biologists, and pharmacologists, and this review includes information from the scientific literature from 1991 to 2022. The study of the chemodiversity of <i>R. uniflorum</i> revealed the presence of 225 compounds, including sesquiterpenes, ecdysteroids, triterpenes, sterols, thiophenes, hydroxycinnamates, flavonoids, lignans, nucleosides and vitamins, alkanes, fatty acids, and carbohydrates. The most studied groups of substances are phenolics (76 compounds) and triterpenoids (69 compounds). Information on the methods of chromatographic analysis of selected compounds, as well as on the quantitative content of some components in various organs of <i>R. uniflorum</i>, is summarized in this work. It has been shown that the extracts and some compounds of <i>R. uniflorum</i> have a wide range of biological activities, including anti-inflammatory, antitumor, immunostimulatory, anxiolytic, stress-protective, actoprotective, antihypoxic, anabolic, hepatoprotective, inhibition of PPARγ receptors, anti-atherosclerotic, and hypolipidemic. Published research on the metabolites and bioactivity of <i>R. uniflorum</i> does not include clinical studies of extracts and pure compounds; therefore, an accurate study of this traditional medicinal plant is needed.https://www.mdpi.com/2218-273X/12/11/1720<i>Rhaponticum uniflorum</i>Compositae (Asteraceae)ecdysteroidsflavonoidsthiophenesHPLC |
| spellingShingle | Daniil N. Olennikov The Ethnopharmacological Uses, Metabolite Diversity, and Bioactivity of <i>Rhaponticum uniflorum</i> (<i>Leuzea uniflora</i>): A Comprehensive Review Biomolecules <i>Rhaponticum uniflorum</i> Compositae (Asteraceae) ecdysteroids flavonoids thiophenes HPLC |
| title | The Ethnopharmacological Uses, Metabolite Diversity, and Bioactivity of <i>Rhaponticum uniflorum</i> (<i>Leuzea uniflora</i>): A Comprehensive Review |
| title_full | The Ethnopharmacological Uses, Metabolite Diversity, and Bioactivity of <i>Rhaponticum uniflorum</i> (<i>Leuzea uniflora</i>): A Comprehensive Review |
| title_fullStr | The Ethnopharmacological Uses, Metabolite Diversity, and Bioactivity of <i>Rhaponticum uniflorum</i> (<i>Leuzea uniflora</i>): A Comprehensive Review |
| title_full_unstemmed | The Ethnopharmacological Uses, Metabolite Diversity, and Bioactivity of <i>Rhaponticum uniflorum</i> (<i>Leuzea uniflora</i>): A Comprehensive Review |
| title_short | The Ethnopharmacological Uses, Metabolite Diversity, and Bioactivity of <i>Rhaponticum uniflorum</i> (<i>Leuzea uniflora</i>): A Comprehensive Review |
| title_sort | ethnopharmacological uses metabolite diversity and bioactivity of i rhaponticum uniflorum i i leuzea uniflora i a comprehensive review |
| topic | <i>Rhaponticum uniflorum</i> Compositae (Asteraceae) ecdysteroids flavonoids thiophenes HPLC |
| url | https://www.mdpi.com/2218-273X/12/11/1720 |
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