Molecular imaging diagnosis of atherosclerotic vulnerable plaque in rabbit carotid artery using a self-assembled nanoscale ultrasound microbubble contrast agent
This study aimed to prepare an anti-Vascular cell adhesion protein 1 (VCAM-1) nanoscale ultrasound microbubble contrast agent using the hyperbranched self-assembly method for the molecular imaging diagnosis of atherosclerotic vulnerable plaques in rabbits. Twenty-five rabbits with carotid atheros...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2021-12-01
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| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://rcm.imrpress.com/EN/10.31083/j.rcm2204173 |
| _version_ | 1819106084227383296 |
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| author | Cong Wang Shaoling Yang Xiaoxue Chen Qianqian He Kun Zhao Jing Hu |
| author_facet | Cong Wang Shaoling Yang Xiaoxue Chen Qianqian He Kun Zhao Jing Hu |
| author_sort | Cong Wang |
| collection | DOAJ |
| description | This study aimed to prepare an anti-Vascular cell adhesion protein 1
(VCAM-1) nanoscale ultrasound microbubble contrast agent using the hyperbranched
self-assembly method for the molecular imaging diagnosis of atherosclerotic
vulnerable plaques in rabbits. Twenty-five rabbits with carotid atherosclerosis
were randomly divided into 5 groups, and the ear vein was injected with agents as
follows: Groups A and B: nanoscale ultrasound
microbubble contrast agent with and without anti-VCAM-1 agent; Groups C and D:
SonoVue ultrasonic microbubble contrast agent, with and without anti-VCAM-1
agent; Control group: saline. The molecular imaging diagnosis of the
atherosclerotic plaque, involved the examination of its vulnerability in the
rabbit carotid artery was performed using the contrast ultrasound mode. The
arrival and peaking time of the anti-VCAM-1 nanoscale ultrasound microbubble
contrast agent (Group A) for plaque occurred earlier than those of the other
groups (p < 0.05), and with it, the plaque showed the strongest
enhancement (p < 0.05), followed by the SonoVue ultrasound microbubble
contrast agent with anti-VCAM-1 group (Group C) and the self-made nanoscale
ultrasound microbubble contrast agent group (Group B). No development was
observed in the plaques of the SonoVue ultrasound microbubble contrast agent
group and the control group. The anti-VCAM-1 nanoscale ultrasonic microbubble
contrast agent, prepared using the self-assembly method, can facilitate the
development effect of the carotid
atherosclerotic vulnerable plaque, providing
a basis for the molecular imaging diagnosis of carotid atherosclerotic vulnerable
plaques. |
| first_indexed | 2024-12-22T02:32:31Z |
| format | Article |
| id | doaj.art-897a58eacacb421eb622ab70dc7b557d |
| institution | Directory Open Access Journal |
| issn | 2153-8174 |
| language | English |
| last_indexed | 2024-12-22T02:32:31Z |
| publishDate | 2021-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-897a58eacacb421eb622ab70dc7b557d2022-12-21T18:41:52ZengIMR PressReviews in Cardiovascular Medicine2153-81742021-12-012241657166610.31083/j.rcm2204173S1530-6550(21)00224-6Molecular imaging diagnosis of atherosclerotic vulnerable plaque in rabbit carotid artery using a self-assembled nanoscale ultrasound microbubble contrast agentCong Wang0Shaoling Yang1Xiaoxue Chen2Qianqian He3Kun Zhao4Jing Hu5Department of Ultrasound, The First Hospital of Anhui University of Science and Technology, 232007 Huainan, Anhui, ChinaDepartment of Ultrasound, The Eighth People’s Hospital of Shanghai, 200235 Shanghai, ChinaDepartment of Cardiovascular Ultrasound, Affiliated Hospital of Anhui University of Science and Technology, 201406 Shanghai, ChinaDepartment of Cardiovascular Ultrasound, Affiliated Hospital of Anhui University of Science and Technology, 201406 Shanghai, ChinaDepartment of Cardiovascular Ultrasound, Affiliated Hospital of Anhui University of Science and Technology, 201406 Shanghai, ChinaDepartment of Cardiovascular Ultrasound, Affiliated Hospital of Anhui University of Science and Technology, 201406 Shanghai, ChinaThis study aimed to prepare an anti-Vascular cell adhesion protein 1 (VCAM-1) nanoscale ultrasound microbubble contrast agent using the hyperbranched self-assembly method for the molecular imaging diagnosis of atherosclerotic vulnerable plaques in rabbits. Twenty-five rabbits with carotid atherosclerosis were randomly divided into 5 groups, and the ear vein was injected with agents as follows: Groups A and B: nanoscale ultrasound microbubble contrast agent with and without anti-VCAM-1 agent; Groups C and D: SonoVue ultrasonic microbubble contrast agent, with and without anti-VCAM-1 agent; Control group: saline. The molecular imaging diagnosis of the atherosclerotic plaque, involved the examination of its vulnerability in the rabbit carotid artery was performed using the contrast ultrasound mode. The arrival and peaking time of the anti-VCAM-1 nanoscale ultrasound microbubble contrast agent (Group A) for plaque occurred earlier than those of the other groups (p < 0.05), and with it, the plaque showed the strongest enhancement (p < 0.05), followed by the SonoVue ultrasound microbubble contrast agent with anti-VCAM-1 group (Group C) and the self-made nanoscale ultrasound microbubble contrast agent group (Group B). No development was observed in the plaques of the SonoVue ultrasound microbubble contrast agent group and the control group. The anti-VCAM-1 nanoscale ultrasonic microbubble contrast agent, prepared using the self-assembly method, can facilitate the development effect of the carotid atherosclerotic vulnerable plaque, providing a basis for the molecular imaging diagnosis of carotid atherosclerotic vulnerable plaques.https://rcm.imrpress.com/EN/10.31083/j.rcm2204173vulnerable plaquetargetedmicrobubbleanti-vcam-1 |
| spellingShingle | Cong Wang Shaoling Yang Xiaoxue Chen Qianqian He Kun Zhao Jing Hu Molecular imaging diagnosis of atherosclerotic vulnerable plaque in rabbit carotid artery using a self-assembled nanoscale ultrasound microbubble contrast agent Reviews in Cardiovascular Medicine vulnerable plaque targeted microbubble anti-vcam-1 |
| title | Molecular imaging diagnosis of atherosclerotic vulnerable plaque in rabbit carotid artery using a self-assembled nanoscale ultrasound microbubble contrast agent |
| title_full | Molecular imaging diagnosis of atherosclerotic vulnerable plaque in rabbit carotid artery using a self-assembled nanoscale ultrasound microbubble contrast agent |
| title_fullStr | Molecular imaging diagnosis of atherosclerotic vulnerable plaque in rabbit carotid artery using a self-assembled nanoscale ultrasound microbubble contrast agent |
| title_full_unstemmed | Molecular imaging diagnosis of atherosclerotic vulnerable plaque in rabbit carotid artery using a self-assembled nanoscale ultrasound microbubble contrast agent |
| title_short | Molecular imaging diagnosis of atherosclerotic vulnerable plaque in rabbit carotid artery using a self-assembled nanoscale ultrasound microbubble contrast agent |
| title_sort | molecular imaging diagnosis of atherosclerotic vulnerable plaque in rabbit carotid artery using a self assembled nanoscale ultrasound microbubble contrast agent |
| topic | vulnerable plaque targeted microbubble anti-vcam-1 |
| url | https://rcm.imrpress.com/EN/10.31083/j.rcm2204173 |
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