Epigenetic and Neuronal Activity Markers Suggest the Recruitment of the Prefrontal Cortex and Hippocampus in the Three-Hit Model of Depression in Male PACAP Heterozygous Mice

Epigenetic and Neuronal Activity Markers Suggest the Recruitment of the Prefrontal Cortex and Hippocampus in the Three-Hit Model of Depression in Male PACAP Heterozygous Mice

Depression and its increasing prevalence challenge patients, the healthcare system, and the economy. We recently created a mouse model based on the three-hit concept of depression. As genetic predisposition (first hit), we applied pituitary adenylate cyclase-activating polypeptide heterozygous mice...

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Bibliographic Details
Main Authors: Tamás Gaszner, József Farkas, Dániel Kun, Balázs Ujvári, Nóra Füredi, László Ákos Kovács, Hitoshi Hashimoto, Dóra Reglődi, Viktória Kormos, Balázs Gaszner
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
histone acetylation
H3K9ac
FOSB
chronic stress
maternal deprivation
Online Access:https://www.mdpi.com/1422-0067/23/19/11739

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