Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings
<i>Background and Objective</i>: Copper, a wide spectrum biocide, also plays a key role in angiogenesis and wound healing. Antibacterial wound dressings impregnated with copper oxide microparticles (COD) have been recently cleared by the U.S. FDA and other regulatory bodies for the treat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/10/1129 |
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| author | Eyal Melamed Alexei Rovitsky Tohar Roth Lior Assa Gadi Borkow |
| author_facet | Eyal Melamed Alexei Rovitsky Tohar Roth Lior Assa Gadi Borkow |
| author_sort | Eyal Melamed |
| collection | DOAJ |
| description | <i>Background and Objective</i>: Copper, a wide spectrum biocide, also plays a key role in angiogenesis and wound healing. Antibacterial wound dressings impregnated with copper oxide microparticles (COD) have been recently cleared by the U.S. FDA and other regulatory bodies for the treatment of acute and chronic wounds, including diabetic wounds. Our objective was to evaluate the capacity of COD in stimulating the healing of non-infected stagnated wounds in diabetic patients initially treated with standard of care (SOC) dressings. <i>Materials and Methods</i>: The trial was divided into the three following phases: 1–2 weeks of screening, during which the patients were treated with SOC dressings; 4 weeks of treatment, during which the COD was applied twice weekly; and 2 weeks of follow-up, during which the patients were again treated with SOC dressings. The wound conditions and sizes were assessed by clinical evaluation and a wound imaging artificial intelligence system. <i>Results</i>: Following 1 month of COD treatment, there was a clear reduction in the mean wound area (53.2%; <i>p</i> = 0.003), an increase in granulation tissue (43.37; <i>p</i> < 0.001), and a reduction in fibrins (47.8%; <i>p</i> = 0.002). In patients with non-weight-bearing wounds, the reduction in wound size was even more dramatic (66.9%; <i>p</i> < 0.001). <i>Conclusions</i>: The results of this study, showing a statistically significant influence of COD on wound healing of hard-to-heal wounds in diabetic patients, strongly supports the notion that copper oxide-impregnated dressings enhance wound healing directly. Further larger controlled studies should be conducted to substantiate our findings. |
| first_indexed | 2024-03-10T06:24:06Z |
| format | Article |
| id | doaj.art-897bd6895f3541aa9872442071a96eed |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T06:24:06Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-897bd6895f3541aa9872442071a96eed2023-11-22T19:05:24ZengMDPI AGMedicina1010-660X1648-91442021-10-015710112910.3390/medicina57101129Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound DressingsEyal Melamed0Alexei Rovitsky1Tohar Roth2Lior Assa3Gadi Borkow4Department of Orthopaedics, Rambam Health Care Campus, Haifa 3109601, IsraelDepartment of Orthopaedics, Rambam Health Care Campus, Haifa 3109601, IsraelMedCu Technologies Ltd., Herzliya 4672200, IsraelMedCu Technologies Ltd., Herzliya 4672200, IsraelMedCu Technologies Ltd., Herzliya 4672200, Israel<i>Background and Objective</i>: Copper, a wide spectrum biocide, also plays a key role in angiogenesis and wound healing. Antibacterial wound dressings impregnated with copper oxide microparticles (COD) have been recently cleared by the U.S. FDA and other regulatory bodies for the treatment of acute and chronic wounds, including diabetic wounds. Our objective was to evaluate the capacity of COD in stimulating the healing of non-infected stagnated wounds in diabetic patients initially treated with standard of care (SOC) dressings. <i>Materials and Methods</i>: The trial was divided into the three following phases: 1–2 weeks of screening, during which the patients were treated with SOC dressings; 4 weeks of treatment, during which the COD was applied twice weekly; and 2 weeks of follow-up, during which the patients were again treated with SOC dressings. The wound conditions and sizes were assessed by clinical evaluation and a wound imaging artificial intelligence system. <i>Results</i>: Following 1 month of COD treatment, there was a clear reduction in the mean wound area (53.2%; <i>p</i> = 0.003), an increase in granulation tissue (43.37; <i>p</i> < 0.001), and a reduction in fibrins (47.8%; <i>p</i> = 0.002). In patients with non-weight-bearing wounds, the reduction in wound size was even more dramatic (66.9%; <i>p</i> < 0.001). <i>Conclusions</i>: The results of this study, showing a statistically significant influence of COD on wound healing of hard-to-heal wounds in diabetic patients, strongly supports the notion that copper oxide-impregnated dressings enhance wound healing directly. Further larger controlled studies should be conducted to substantiate our findings.https://www.mdpi.com/1648-9144/57/10/1129copper oxidediabetesprospective studywound dressingswound healing |
| spellingShingle | Eyal Melamed Alexei Rovitsky Tohar Roth Lior Assa Gadi Borkow Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings Medicina copper oxide diabetes prospective study wound dressings wound healing |
| title | Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings |
| title_full | Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings |
| title_fullStr | Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings |
| title_full_unstemmed | Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings |
| title_short | Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings |
| title_sort | stimulation of healing of non infected stagnated diabetic wounds by copper oxide impregnated wound dressings |
| topic | copper oxide diabetes prospective study wound dressings wound healing |
| url | https://www.mdpi.com/1648-9144/57/10/1129 |
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