Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase

Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase

Sufferers of cystic fibrosis are at significant risk of contracting chronic bacterial lung infections. The dominant pathogen in these cases is mucoid Pseudomonas aeruginosa. Such infections are characterised by overproduction of the exopolysaccharide alginate. We present herein the design and chemoe...

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Bibliographic Details
Main Authors: Sanaz Ahmadipour, Alice J. C. Wahart, Jonathan P. Dolan, Laura Beswick, Chris S. Hawes, Robert A. Field, Gavin J. Miller
Format: Article
Language:English
Published: Beilstein-Institut 2022-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
alginate
chemical probe
enzymatic synthesis
gdp-mannose dehydrogenase
sugar nucleotide
Online Access:https://doi.org/10.3762/bjoc.18.142

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