Electronic Microscopy aspects of experimentally induced chronic arthritis
Introduction: Chronic diseases are responsible for about 38 million deaths annually and repre-sent about 70% of all deaths worldwide. Among these, rheumatoid arthritis is the most com-mon inflammatory rheumatic dis-ease, representing about 10% of all such disorders. Its inci-dence is approximately 1...
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| Format: | Article |
| Language: | English |
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Romanian Association of Balneology, Editura Balneara
2024-03-01
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| Series: | Balneo and PRM Research Journal |
| Subjects: | |
| Online Access: | https://bioclima.ro/Balneo663.pdf |
| _version_ | 1797229526237839360 |
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| author | Mihaiela Chicu Alexandra Lori Donica Bianca Andreea Onofrei Madalina Ioana Matran-Dan |
| author_facet | Mihaiela Chicu Alexandra Lori Donica Bianca Andreea Onofrei Madalina Ioana Matran-Dan |
| author_sort | Mihaiela Chicu |
| collection | DOAJ |
| description | Introduction: Chronic diseases are responsible for about 38 million deaths annually and repre-sent about 70% of all deaths worldwide. Among these, rheumatoid arthritis is the most com-mon inflammatory rheumatic dis-ease, representing about 10% of all such disorders. Its inci-dence is approximately 1% of the general popula-tion.
Material and method: our study aims to create an experimental model of chronic arthritis on Wistar rats, fe-male sex, to follow the dynamics of joint inflammatory phenomena, the effects of Leflunomide in their evolu-tion and the side effects at cardiac, hepatic and renal level.
Discussions: The group of young experimental animals developed more extensive inflamma-tory phenomena compared to the group of adult animals. Leflunomide did not significantly improve the evolution and resolu-tion of inflammatory phenomena in either group.
Conclusions: We showed for the first time in the world the effects of Leflunomide on the heart, with the occur-rence of myocardial necrosis ( myocardial infarction) as its main adverse effect. |
| first_indexed | 2024-04-24T15:13:59Z |
| format | Article |
| id | doaj.art-89813896852a4c9b9c4b6a04dd48f9eb |
| institution | Directory Open Access Journal |
| issn | 2734-8458 |
| language | English |
| last_indexed | 2024-04-24T15:13:59Z |
| publishDate | 2024-03-01 |
| publisher | Romanian Association of Balneology, Editura Balneara |
| record_format | Article |
| series | Balneo and PRM Research Journal |
| spelling | doaj.art-89813896852a4c9b9c4b6a04dd48f9eb2024-04-02T09:40:32ZengRomanian Association of Balneology, Editura BalnearaBalneo and PRM Research Journal2734-84582024-03-0115166310.12680/balneo.2024.663Electronic Microscopy aspects of experimentally induced chronic arthritisMihaiela Chicu0Alexandra Lori Donica1Bianca Andreea Onofrei2Madalina Ioana Matran-Dan3Department of Phisiopathology, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, University Street, No. 16, 700115 Iasi, RomaniaClinical Recovery Hospital, 700661 Iasi, RomaniaDepartment, Faculty of Dental Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, University Street, No. 16, 700115 Iasi, RomaniaClinical Recovery Hospital, 700661 Iasi, RomaniaIntroduction: Chronic diseases are responsible for about 38 million deaths annually and repre-sent about 70% of all deaths worldwide. Among these, rheumatoid arthritis is the most com-mon inflammatory rheumatic dis-ease, representing about 10% of all such disorders. Its inci-dence is approximately 1% of the general popula-tion. Material and method: our study aims to create an experimental model of chronic arthritis on Wistar rats, fe-male sex, to follow the dynamics of joint inflammatory phenomena, the effects of Leflunomide in their evolu-tion and the side effects at cardiac, hepatic and renal level. Discussions: The group of young experimental animals developed more extensive inflamma-tory phenomena compared to the group of adult animals. Leflunomide did not significantly improve the evolution and resolu-tion of inflammatory phenomena in either group. Conclusions: We showed for the first time in the world the effects of Leflunomide on the heart, with the occur-rence of myocardial necrosis ( myocardial infarction) as its main adverse effect.https://bioclima.ro/Balneo663.pdfarthritisleflunomide |
| spellingShingle | Mihaiela Chicu Alexandra Lori Donica Bianca Andreea Onofrei Madalina Ioana Matran-Dan Electronic Microscopy aspects of experimentally induced chronic arthritis Balneo and PRM Research Journal arthritis leflunomide |
| title | Electronic Microscopy aspects of experimentally induced chronic arthritis |
| title_full | Electronic Microscopy aspects of experimentally induced chronic arthritis |
| title_fullStr | Electronic Microscopy aspects of experimentally induced chronic arthritis |
| title_full_unstemmed | Electronic Microscopy aspects of experimentally induced chronic arthritis |
| title_short | Electronic Microscopy aspects of experimentally induced chronic arthritis |
| title_sort | electronic microscopy aspects of experimentally induced chronic arthritis |
| topic | arthritis leflunomide |
| url | https://bioclima.ro/Balneo663.pdf |
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