Transcranial Magnetic Stimulation for Long-Term Smoking Cessation: Preliminary Examination of Delay Discounting as a Therapeutic Target and the Effects of Intensity and Duration
BackgroundRepetitive transcranial magnetic stimulation (rTMS) is a novel treatment for smoking cessation and delay discounting rate is novel therapeutic target. Research to determine optimal therapeutic targets and dosing parameters for long-term smoking cessation is needed. Due to potential biases...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.920383/full |
| _version_ | 1818113317233754112 |
|---|---|
| author | Alina Shevorykin Ellen Carl Martin C. Mahoney Colleen A. Hanlon Amylynn Liskiewicz Cheryl Rivard Ronald Alberico Ahmed Belal Lindsey Bensch Darian Vantucci Hannah Thorner Matthew Marion Warren K. Bickel Christine E. Sheffer |
| author_facet | Alina Shevorykin Ellen Carl Martin C. Mahoney Colleen A. Hanlon Amylynn Liskiewicz Cheryl Rivard Ronald Alberico Ahmed Belal Lindsey Bensch Darian Vantucci Hannah Thorner Matthew Marion Warren K. Bickel Christine E. Sheffer |
| author_sort | Alina Shevorykin |
| collection | DOAJ |
| description | BackgroundRepetitive transcranial magnetic stimulation (rTMS) is a novel treatment for smoking cessation and delay discounting rate is novel therapeutic target. Research to determine optimal therapeutic targets and dosing parameters for long-term smoking cessation is needed. Due to potential biases and confounds introduced by the COVID-19 pandemic, we report preliminary results from an ongoing study among participants who reached study end prior to the pandemic.MethodsIn a 3 × 2 randomized factorial design, participants (n = 23) received 900 pulses of 20 Hz rTMS to the left dorsolateral prefrontal cortex (PFC) in one of three Durations (8, 12, or 16 days of stimulation) and two Intensities (1 or 2 sessions per day). We examined direction and magnitude of the effect sizes on latency to relapse, 6-month point-prevalence abstinence rates, research burden, and delay discounting rates.ResultsA large effect size was found for Duration and a medium for Intensity for latency to relapse. Increasing Duration increased the odds of abstinence 7–8-fold while increasing Intensity doubled the odds of abstinence. A large effect size was found for Duration, a small for Intensity for delay discounting rate. Increasing Duration and Intensity had a small effect on participant burden.ConclusionFindings provide preliminary support for delay discounting as a therapeutic target and for increasing Duration and Intensity to achieve larger effect sizes for long-term smoking cessation and will provide a pre-pandemic comparison for data collected during the pandemic.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [NCT03865472]. |
| first_indexed | 2024-12-11T03:32:54Z |
| format | Article |
| id | doaj.art-8981e39c513748dca15511c2386478ff |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-11T03:32:54Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-8981e39c513748dca15511c2386478ff2022-12-22T01:22:20ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-07-011610.3389/fnhum.2022.920383920383Transcranial Magnetic Stimulation for Long-Term Smoking Cessation: Preliminary Examination of Delay Discounting as a Therapeutic Target and the Effects of Intensity and DurationAlina Shevorykin0Ellen Carl1Martin C. Mahoney2Colleen A. Hanlon3Amylynn Liskiewicz4Cheryl Rivard5Ronald Alberico6Ahmed Belal7Lindsey Bensch8Darian Vantucci9Hannah Thorner10Matthew Marion11Warren K. Bickel12Christine E. Sheffer13Roswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesRoswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesRoswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesWake Forest School of Medicine, Winston-Salem, NC, United StatesRoswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesRoswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesRoswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesRoswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesRoswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesRoswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesRoswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesRoswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, United StatesRoswell Park Comprehensive Cancer Center, Buffalo, NY, United StatesBackgroundRepetitive transcranial magnetic stimulation (rTMS) is a novel treatment for smoking cessation and delay discounting rate is novel therapeutic target. Research to determine optimal therapeutic targets and dosing parameters for long-term smoking cessation is needed. Due to potential biases and confounds introduced by the COVID-19 pandemic, we report preliminary results from an ongoing study among participants who reached study end prior to the pandemic.MethodsIn a 3 × 2 randomized factorial design, participants (n = 23) received 900 pulses of 20 Hz rTMS to the left dorsolateral prefrontal cortex (PFC) in one of three Durations (8, 12, or 16 days of stimulation) and two Intensities (1 or 2 sessions per day). We examined direction and magnitude of the effect sizes on latency to relapse, 6-month point-prevalence abstinence rates, research burden, and delay discounting rates.ResultsA large effect size was found for Duration and a medium for Intensity for latency to relapse. Increasing Duration increased the odds of abstinence 7–8-fold while increasing Intensity doubled the odds of abstinence. A large effect size was found for Duration, a small for Intensity for delay discounting rate. Increasing Duration and Intensity had a small effect on participant burden.ConclusionFindings provide preliminary support for delay discounting as a therapeutic target and for increasing Duration and Intensity to achieve larger effect sizes for long-term smoking cessation and will provide a pre-pandemic comparison for data collected during the pandemic.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [NCT03865472].https://www.frontiersin.org/articles/10.3389/fnhum.2022.920383/fulltranscranial magnetic stimulationsmoking cessationtobacco dependence treatmentdelay discountingself-regulationbrain stimulation |
| spellingShingle | Alina Shevorykin Ellen Carl Martin C. Mahoney Colleen A. Hanlon Amylynn Liskiewicz Cheryl Rivard Ronald Alberico Ahmed Belal Lindsey Bensch Darian Vantucci Hannah Thorner Matthew Marion Warren K. Bickel Christine E. Sheffer Transcranial Magnetic Stimulation for Long-Term Smoking Cessation: Preliminary Examination of Delay Discounting as a Therapeutic Target and the Effects of Intensity and Duration Frontiers in Human Neuroscience transcranial magnetic stimulation smoking cessation tobacco dependence treatment delay discounting self-regulation brain stimulation |
| title | Transcranial Magnetic Stimulation for Long-Term Smoking Cessation: Preliminary Examination of Delay Discounting as a Therapeutic Target and the Effects of Intensity and Duration |
| title_full | Transcranial Magnetic Stimulation for Long-Term Smoking Cessation: Preliminary Examination of Delay Discounting as a Therapeutic Target and the Effects of Intensity and Duration |
| title_fullStr | Transcranial Magnetic Stimulation for Long-Term Smoking Cessation: Preliminary Examination of Delay Discounting as a Therapeutic Target and the Effects of Intensity and Duration |
| title_full_unstemmed | Transcranial Magnetic Stimulation for Long-Term Smoking Cessation: Preliminary Examination of Delay Discounting as a Therapeutic Target and the Effects of Intensity and Duration |
| title_short | Transcranial Magnetic Stimulation for Long-Term Smoking Cessation: Preliminary Examination of Delay Discounting as a Therapeutic Target and the Effects of Intensity and Duration |
| title_sort | transcranial magnetic stimulation for long term smoking cessation preliminary examination of delay discounting as a therapeutic target and the effects of intensity and duration |
| topic | transcranial magnetic stimulation smoking cessation tobacco dependence treatment delay discounting self-regulation brain stimulation |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.920383/full |
| work_keys_str_mv | AT alinashevorykin transcranialmagneticstimulationforlongtermsmokingcessationpreliminaryexaminationofdelaydiscountingasatherapeutictargetandtheeffectsofintensityandduration AT ellencarl transcranialmagneticstimulationforlongtermsmokingcessationpreliminaryexaminationofdelaydiscountingasatherapeutictargetandtheeffectsofintensityandduration AT martincmahoney transcranialmagneticstimulationforlongtermsmokingcessationpreliminaryexaminationofdelaydiscountingasatherapeutictargetandtheeffectsofintensityandduration AT colleenahanlon transcranialmagneticstimulationforlongtermsmokingcessationpreliminaryexaminationofdelaydiscountingasatherapeutictargetandtheeffectsofintensityandduration AT amylynnliskiewicz transcranialmagneticstimulationforlongtermsmokingcessationpreliminaryexaminationofdelaydiscountingasatherapeutictargetandtheeffectsofintensityandduration AT cherylrivard transcranialmagneticstimulationforlongtermsmokingcessationpreliminaryexaminationofdelaydiscountingasatherapeutictargetandtheeffectsofintensityandduration AT ronaldalberico transcranialmagneticstimulationforlongtermsmokingcessationpreliminaryexaminationofdelaydiscountingasatherapeutictargetandtheeffectsofintensityandduration AT ahmedbelal transcranialmagneticstimulationforlongtermsmokingcessationpreliminaryexaminationofdelaydiscountingasatherapeutictargetandtheeffectsofintensityandduration AT lindseybensch transcranialmagneticstimulationforlongtermsmokingcessationpreliminaryexaminationofdelaydiscountingasatherapeutictargetandtheeffectsofintensityandduration AT darianvantucci transcranialmagneticstimulationforlongtermsmokingcessationpreliminaryexaminationofdelaydiscountingasatherapeutictargetandtheeffectsofintensityandduration AT hannahthorner transcranialmagneticstimulationforlongtermsmokingcessationpreliminaryexaminationofdelaydiscountingasatherapeutictargetandtheeffectsofintensityandduration AT matthewmarion transcranialmagneticstimulationforlongtermsmokingcessationpreliminaryexaminationofdelaydiscountingasatherapeutictargetandtheeffectsofintensityandduration AT warrenkbickel transcranialmagneticstimulationforlongtermsmokingcessationpreliminaryexaminationofdelaydiscountingasatherapeutictargetandtheeffectsofintensityandduration AT christineesheffer transcranialmagneticstimulationforlongtermsmokingcessationpreliminaryexaminationofdelaydiscountingasatherapeutictargetandtheeffectsofintensityandduration |