Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders
Functional foods enriched with plant polyphenols and anthocyanins in particular attract special attention due to multiple beneficial bioactive properties of the latter. We evaluated the effects of a grain diet rich in anthocyanins in a mouse model of Alzheimer’s disease induced by amyloid-beta (Aβ)...
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MDPI AG
2020-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/12/3877 |
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| author | Maria A. Tikhonova Olesya Yu. Shoeva Michael V. Tenditnik Marina V. Ovsyukova Anna A. Akopyan Nina I. Dubrovina Tamara G. Amstislavskaya Elena K. Khlestkina |
| author_facet | Maria A. Tikhonova Olesya Yu. Shoeva Michael V. Tenditnik Marina V. Ovsyukova Anna A. Akopyan Nina I. Dubrovina Tamara G. Amstislavskaya Elena K. Khlestkina |
| author_sort | Maria A. Tikhonova |
| collection | DOAJ |
| description | Functional foods enriched with plant polyphenols and anthocyanins in particular attract special attention due to multiple beneficial bioactive properties of the latter. We evaluated the effects of a grain diet rich in anthocyanins in a mouse model of Alzheimer’s disease induced by amyloid-beta (Aβ) and a transgenic mouse model of Parkinson’s disease (PD) with overexpression of human alpha-synuclein. The mice were kept at a diet that consisted of the wheat grain of near isogenic lines differing in anthocyanin content for five–six months. The anthocyanin-rich diet was safe and possessed positive effects on cognitive function. Anthocyanins prevented deficits in working memory induced by Aβ or a long-term grain mono-diet; they partially reversed episodic memory alterations. Both types of grain diets prolonged memory extinction and rescued its facilitation in the PD model. The dynamics of the extinction in the group fed with the anthocyanin-rich wheat was closer to that in a group of wild-type mice given standard chow. The anthocyanin-rich diet reduced alpha-synuclein accumulation and modulated microglial response in the brain of the transgenic mice including the elevated expression of arginase1 that marks M2 microglia. Thus, anthocyanin-rich wheat is suggested as a promising source of functional nutrition at the early stages of neurodegenerative disorders. |
| first_indexed | 2024-03-10T13:57:16Z |
| format | Article |
| id | doaj.art-8982a674b9a047339288f878812c5b2f |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T13:57:16Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-8982a674b9a047339288f878812c5b2f2023-11-21T01:29:14ZengMDPI AGNutrients2072-66432020-12-011212387710.3390/nu12123877Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative DisordersMaria A. Tikhonova0Olesya Yu. Shoeva1Michael V. Tenditnik2Marina V. Ovsyukova3Anna A. Akopyan4Nina I. Dubrovina5Tamara G. Amstislavskaya6Elena K. Khlestkina7Federal Research Center “Institute of Cytology and Genetics”, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, RussiaFederal Research Center “Institute of Cytology and Genetics”, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, RussiaFederal State Budgetary Scientific Institution “Scientific Research Institute of Neurosciences and Medicine” (SRINM), 630117 Novosibirsk, RussiaFederal State Budgetary Scientific Institution “Scientific Research Institute of Neurosciences and Medicine” (SRINM), 630117 Novosibirsk, RussiaFederal State Budgetary Scientific Institution “Scientific Research Institute of Neurosciences and Medicine” (SRINM), 630117 Novosibirsk, RussiaFederal State Budgetary Scientific Institution “Scientific Research Institute of Neurosciences and Medicine” (SRINM), 630117 Novosibirsk, RussiaFederal Research Center “Institute of Cytology and Genetics”, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, RussiaFederal Research Center “Institute of Cytology and Genetics”, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, RussiaFunctional foods enriched with plant polyphenols and anthocyanins in particular attract special attention due to multiple beneficial bioactive properties of the latter. We evaluated the effects of a grain diet rich in anthocyanins in a mouse model of Alzheimer’s disease induced by amyloid-beta (Aβ) and a transgenic mouse model of Parkinson’s disease (PD) with overexpression of human alpha-synuclein. The mice were kept at a diet that consisted of the wheat grain of near isogenic lines differing in anthocyanin content for five–six months. The anthocyanin-rich diet was safe and possessed positive effects on cognitive function. Anthocyanins prevented deficits in working memory induced by Aβ or a long-term grain mono-diet; they partially reversed episodic memory alterations. Both types of grain diets prolonged memory extinction and rescued its facilitation in the PD model. The dynamics of the extinction in the group fed with the anthocyanin-rich wheat was closer to that in a group of wild-type mice given standard chow. The anthocyanin-rich diet reduced alpha-synuclein accumulation and modulated microglial response in the brain of the transgenic mice including the elevated expression of arginase1 that marks M2 microglia. Thus, anthocyanin-rich wheat is suggested as a promising source of functional nutrition at the early stages of neurodegenerative disorders.https://www.mdpi.com/2072-6643/12/12/3877bioflavonoidsfunctional foodneurodegenerationcognitiveT-mazeBarnes test |
| spellingShingle | Maria A. Tikhonova Olesya Yu. Shoeva Michael V. Tenditnik Marina V. Ovsyukova Anna A. Akopyan Nina I. Dubrovina Tamara G. Amstislavskaya Elena K. Khlestkina Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders Nutrients bioflavonoids functional food neurodegeneration cognitive T-maze Barnes test |
| title | Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders |
| title_full | Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders |
| title_fullStr | Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders |
| title_full_unstemmed | Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders |
| title_short | Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders |
| title_sort | evaluating the effects of grain of isogenic wheat lines differing in the content of anthocyanins in mouse models of neurodegenerative disorders |
| topic | bioflavonoids functional food neurodegeneration cognitive T-maze Barnes test |
| url | https://www.mdpi.com/2072-6643/12/12/3877 |
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