Lack of association between airflow limitation and recurrence of venous thromboembolism among cancer patients with pulmonary embolism
Sun Hye Shin,1 Danbee Kang,2 Juhee Cho,2 Haseong Chang,3 Min Sun Kim,3 Su Yeon Lee,3 Hyun Lee,1 Hojoong Kim,1 Duk-Kyung Kim,3 Eun Kyoung Kim,3,* Hye Yun Park1,* 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2018-03-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/lack-of-association-between-airflow-limitation-and-recurrence-of-venou-peer-reviewed-article-COPD |
| _version_ | 1819158058974052352 |
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| author | Shin SH Kang D Cho J Chang H Kim MS Lee SY Lee H Kim H Kim DK Kim EK Park HY |
| author_facet | Shin SH Kang D Cho J Chang H Kim MS Lee SY Lee H Kim H Kim DK Kim EK Park HY |
| author_sort | Shin SH |
| collection | DOAJ |
| description | Sun Hye Shin,1 Danbee Kang,2 Juhee Cho,2 Haseong Chang,3 Min Sun Kim,3 Su Yeon Lee,3 Hyun Lee,1 Hojoong Kim,1 Duk-Kyung Kim,3 Eun Kyoung Kim,3,* Hye Yun Park1,* 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; 2Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, South Korea; 3Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea *These authors contributed equally to this work Background: COPD is a well-known risk factor for venous thromboembolism (VTE) development. However, recent data showed that it was not associated with VTE recurrence risk, which excluded cancer patients. This study investigated the association of airflow limitation and VTE recurrence in cancer patients with pulmonary embolism (PE). Methods: This is a retrospective cohort study of cancer patients with newly diagnosed PE at a university hospital. PE was confirmed using contrast-enhanced computed tomography scan. Airflow limitation was defined as pre-bronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) <0.7 within 2 years of PE diagnosis. VTE recurrence was defined as a composite of recurrence as PE or deep vein thrombosis or both. Results: Among 401 cancer patients with newly diagnosed PE, spirometry-based airflow limitation was observed in 126 (31.4%) patients. Half of the patients had lung cancer, which was more common in the group with airflow limitation (65.1% vs 42.9%, p < 0.001). Symptomatic PE was present in less than half (45.4%) of the cases, and 62.6% of patients were treated for PE. During the median follow-up period of 9.7 months, VTE recurred in 49 (12.2%) patients. Compared with patients without airflow limitation, those with airflow limitation did not have an increased risk of VTE recurrence in univariate or multivariate analyses (adjusted hazard ratio, 1.29 [95% CI 0.68, 2.45]). Conclusion: The presence of airflow limitation did not increase the risk of VTE recurrence in cancer patients with PE. Prospective studies are needed to validate this finding. Keywords: chronic obstructive pulmonary disease, cancer, pulmonary embolism, recurrence, venous thromboembolism |
| first_indexed | 2024-12-22T16:18:38Z |
| format | Article |
| id | doaj.art-89841e8db07246c7b03e6892c85bddac |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-22T16:18:38Z |
| publishDate | 2018-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-89841e8db07246c7b03e6892c85bddac2022-12-21T18:20:18ZengDove Medical PressInternational Journal of COPD1178-20052018-03-01Volume 1393794337338Lack of association between airflow limitation and recurrence of venous thromboembolism among cancer patients with pulmonary embolismShin SHKang DCho JChang HKim MSLee SYLee HKim HKim DKKim EKPark HYSun Hye Shin,1 Danbee Kang,2 Juhee Cho,2 Haseong Chang,3 Min Sun Kim,3 Su Yeon Lee,3 Hyun Lee,1 Hojoong Kim,1 Duk-Kyung Kim,3 Eun Kyoung Kim,3,* Hye Yun Park1,* 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; 2Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, South Korea; 3Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea *These authors contributed equally to this work Background: COPD is a well-known risk factor for venous thromboembolism (VTE) development. However, recent data showed that it was not associated with VTE recurrence risk, which excluded cancer patients. This study investigated the association of airflow limitation and VTE recurrence in cancer patients with pulmonary embolism (PE). Methods: This is a retrospective cohort study of cancer patients with newly diagnosed PE at a university hospital. PE was confirmed using contrast-enhanced computed tomography scan. Airflow limitation was defined as pre-bronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) <0.7 within 2 years of PE diagnosis. VTE recurrence was defined as a composite of recurrence as PE or deep vein thrombosis or both. Results: Among 401 cancer patients with newly diagnosed PE, spirometry-based airflow limitation was observed in 126 (31.4%) patients. Half of the patients had lung cancer, which was more common in the group with airflow limitation (65.1% vs 42.9%, p < 0.001). Symptomatic PE was present in less than half (45.4%) of the cases, and 62.6% of patients were treated for PE. During the median follow-up period of 9.7 months, VTE recurred in 49 (12.2%) patients. Compared with patients without airflow limitation, those with airflow limitation did not have an increased risk of VTE recurrence in univariate or multivariate analyses (adjusted hazard ratio, 1.29 [95% CI 0.68, 2.45]). Conclusion: The presence of airflow limitation did not increase the risk of VTE recurrence in cancer patients with PE. Prospective studies are needed to validate this finding. Keywords: chronic obstructive pulmonary disease, cancer, pulmonary embolism, recurrence, venous thromboembolismhttps://www.dovepress.com/lack-of-association-between-airflow-limitation-and-recurrence-of-venou-peer-reviewed-article-COPDchronic obstructive pulmonary diseasecancerpulmonary embolismrecurrencevenous thromboembolism |
| spellingShingle | Shin SH Kang D Cho J Chang H Kim MS Lee SY Lee H Kim H Kim DK Kim EK Park HY Lack of association between airflow limitation and recurrence of venous thromboembolism among cancer patients with pulmonary embolism International Journal of COPD chronic obstructive pulmonary disease cancer pulmonary embolism recurrence venous thromboembolism |
| title | Lack of association between airflow limitation and recurrence of venous thromboembolism among cancer patients with pulmonary embolism |
| title_full | Lack of association between airflow limitation and recurrence of venous thromboembolism among cancer patients with pulmonary embolism |
| title_fullStr | Lack of association between airflow limitation and recurrence of venous thromboembolism among cancer patients with pulmonary embolism |
| title_full_unstemmed | Lack of association between airflow limitation and recurrence of venous thromboembolism among cancer patients with pulmonary embolism |
| title_short | Lack of association between airflow limitation and recurrence of venous thromboembolism among cancer patients with pulmonary embolism |
| title_sort | lack of association between airflow limitation and recurrence of venous thromboembolism among cancer patients with pulmonary embolism |
| topic | chronic obstructive pulmonary disease cancer pulmonary embolism recurrence venous thromboembolism |
| url | https://www.dovepress.com/lack-of-association-between-airflow-limitation-and-recurrence-of-venou-peer-reviewed-article-COPD |
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