Plasma dipeptidyl-peptidase-4 activity is associated with left ventricular systolic function in patients with ST-segment elevation myocardial infarction
Abstract Plasma dipeptidyl-peptidase-4 activity (DPP4a) is inversely associated with left ventricular function in patients with heart failure (HF) or diabetes. However, the association between DPP4a and left ventricular function in ST-segment elevation myocardial infarction (STEMI) patients has not...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-07-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-06514-3 |
| _version_ | 1818750777165873152 |
|---|---|
| author | Jing Wei Li Yun Dai Chen Yu Qi Liu Jin Da Wang Wei Ren Chen Ying Qian Zhang Qiang Ma |
| author_facet | Jing Wei Li Yun Dai Chen Yu Qi Liu Jin Da Wang Wei Ren Chen Ying Qian Zhang Qiang Ma |
| author_sort | Jing Wei Li |
| collection | DOAJ |
| description | Abstract Plasma dipeptidyl-peptidase-4 activity (DPP4a) is inversely associated with left ventricular function in patients with heart failure (HF) or diabetes. However, the association between DPP4a and left ventricular function in ST-segment elevation myocardial infarction (STEMI) patients has not been reported. We studied this association in 584 consecutive STEMI patients at a tertiary referral center from July 2014 to October 2015. DPP4a and plasma N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) levels were quantified by enzymatic assays. The median serum NT-proBNP levels were highest in patients of the lowest tertile (T1) of DPP4a compared with that of the highest tertile (T3) (p = 0.028). The STEMI patients in T1 exhibited lower left ventricular systolic function (T1 vs. T3: left ventricular ejection fraction (LVEF): 50.13 ± 9.12 vs. 52.85 ± 6.82%, p = 0.001). Multivariate logistic-regression analyses (adjusted for confounding variables) showed that a 1 U/L increase in DPP4a was associated with a decreased incidence of left ventricular systolic dysfunction (LVSD) (adjusted odds ratio: 0.90; 95% CI: 0.87–0.94; p < 0.01). In conclusion, low DPP4a is independently associated with LVSD in STEMI patients, which suggests that DPP4 may be involved in the mechanisms of LVSD in STEMI patients. |
| first_indexed | 2024-12-18T04:25:04Z |
| format | Article |
| id | doaj.art-8986382ab998465e95377da0e4c9366a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T04:25:04Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8986382ab998465e95377da0e4c9366a2022-12-21T21:21:07ZengNature PortfolioScientific Reports2045-23222017-07-01711810.1038/s41598-017-06514-3Plasma dipeptidyl-peptidase-4 activity is associated with left ventricular systolic function in patients with ST-segment elevation myocardial infarctionJing Wei Li0Yun Dai Chen1Yu Qi Liu2Jin Da Wang3Wei Ren Chen4Ying Qian Zhang5Qiang Ma6Department of Cardiology, PLA General HospitalDepartment of Cardiology, PLA General HospitalDepartment of Cardiology, PLA General HospitalDepartment of Cardiology, PLA General HospitalDepartment of Cardiology, PLA General HospitalDepartment of Cardiology, PLA General HospitalDepartment of Cardiology, PLA General HospitalAbstract Plasma dipeptidyl-peptidase-4 activity (DPP4a) is inversely associated with left ventricular function in patients with heart failure (HF) or diabetes. However, the association between DPP4a and left ventricular function in ST-segment elevation myocardial infarction (STEMI) patients has not been reported. We studied this association in 584 consecutive STEMI patients at a tertiary referral center from July 2014 to October 2015. DPP4a and plasma N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) levels were quantified by enzymatic assays. The median serum NT-proBNP levels were highest in patients of the lowest tertile (T1) of DPP4a compared with that of the highest tertile (T3) (p = 0.028). The STEMI patients in T1 exhibited lower left ventricular systolic function (T1 vs. T3: left ventricular ejection fraction (LVEF): 50.13 ± 9.12 vs. 52.85 ± 6.82%, p = 0.001). Multivariate logistic-regression analyses (adjusted for confounding variables) showed that a 1 U/L increase in DPP4a was associated with a decreased incidence of left ventricular systolic dysfunction (LVSD) (adjusted odds ratio: 0.90; 95% CI: 0.87–0.94; p < 0.01). In conclusion, low DPP4a is independently associated with LVSD in STEMI patients, which suggests that DPP4 may be involved in the mechanisms of LVSD in STEMI patients.https://doi.org/10.1038/s41598-017-06514-3 |
| spellingShingle | Jing Wei Li Yun Dai Chen Yu Qi Liu Jin Da Wang Wei Ren Chen Ying Qian Zhang Qiang Ma Plasma dipeptidyl-peptidase-4 activity is associated with left ventricular systolic function in patients with ST-segment elevation myocardial infarction Scientific Reports |
| title | Plasma dipeptidyl-peptidase-4 activity is associated with left ventricular systolic function in patients with ST-segment elevation myocardial infarction |
| title_full | Plasma dipeptidyl-peptidase-4 activity is associated with left ventricular systolic function in patients with ST-segment elevation myocardial infarction |
| title_fullStr | Plasma dipeptidyl-peptidase-4 activity is associated with left ventricular systolic function in patients with ST-segment elevation myocardial infarction |
| title_full_unstemmed | Plasma dipeptidyl-peptidase-4 activity is associated with left ventricular systolic function in patients with ST-segment elevation myocardial infarction |
| title_short | Plasma dipeptidyl-peptidase-4 activity is associated with left ventricular systolic function in patients with ST-segment elevation myocardial infarction |
| title_sort | plasma dipeptidyl peptidase 4 activity is associated with left ventricular systolic function in patients with st segment elevation myocardial infarction |
| url | https://doi.org/10.1038/s41598-017-06514-3 |
| work_keys_str_mv | AT jingweili plasmadipeptidylpeptidase4activityisassociatedwithleftventricularsystolicfunctioninpatientswithstsegmentelevationmyocardialinfarction AT yundaichen plasmadipeptidylpeptidase4activityisassociatedwithleftventricularsystolicfunctioninpatientswithstsegmentelevationmyocardialinfarction AT yuqiliu plasmadipeptidylpeptidase4activityisassociatedwithleftventricularsystolicfunctioninpatientswithstsegmentelevationmyocardialinfarction AT jindawang plasmadipeptidylpeptidase4activityisassociatedwithleftventricularsystolicfunctioninpatientswithstsegmentelevationmyocardialinfarction AT weirenchen plasmadipeptidylpeptidase4activityisassociatedwithleftventricularsystolicfunctioninpatientswithstsegmentelevationmyocardialinfarction AT yingqianzhang plasmadipeptidylpeptidase4activityisassociatedwithleftventricularsystolicfunctioninpatientswithstsegmentelevationmyocardialinfarction AT qiangma plasmadipeptidylpeptidase4activityisassociatedwithleftventricularsystolicfunctioninpatientswithstsegmentelevationmyocardialinfarction |