WBP2 Downregulation Inhibits Proliferation by Blocking YAP Transcription and the EGFR/PI3K/Akt Signaling Pathway in Triple Negative Breast Cancer

WBP2 Downregulation Inhibits Proliferation by Blocking YAP Transcription and the EGFR/PI3K/Akt Signaling Pathway in Triple Negative Breast Cancer

Background/Aims: Dysregulated expression of WW domain-binding protein 2 (WBP2) is associated with poor prognosis in ER+ breast cancer patients. However, its role in triple negative breast cancer (TNBC) has not been previously assessed. Therefore, we aimed to elucidate the functional mechanism of WBP...

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Bibliographic Details
Main Authors: Hongming Song, Tianqi Wu, Dan Xie, Dengfeng Li, Kaiyao Hua, Jiashu Hu, Lin Fang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Ww domain-binding protein 2 (WBP2)
Triple Negative Breast Cancer (TNBC)
MiR-613
Proliferation
Apoptosis
Online Access:https://www.karger.com/Article/FullText/492520

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