Deciphering the crosstalk between inflammation and biofilm in chronic wound healing: Phytocompounds loaded bionanomaterials as therapeutics
In terms of the economics and public health, chronic wounds exert a significant detrimental impact on the health care system. Bacterial infections, which cause the formation of highly resistant biofilms that elude standard antibiotics, are the main cause of chronic, non-healing wounds. Numerous stud...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Saudi Journal of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319562X2400041X |
| _version_ | 1797262931326402560 |
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| author | Srivarshini Sankar Gothandam Kodiveri Muthukaliannan |
| author_facet | Srivarshini Sankar Gothandam Kodiveri Muthukaliannan |
| author_sort | Srivarshini Sankar |
| collection | DOAJ |
| description | In terms of the economics and public health, chronic wounds exert a significant detrimental impact on the health care system. Bacterial infections, which cause the formation of highly resistant biofilms that elude standard antibiotics, are the main cause of chronic, non-healing wounds. Numerous studies have shown that phytochemicals are effective in treating a variety of diseases, and traditional medicinal plants often include important chemical groups such alkaloids, phenolics, tannins, terpenes, steroids, flavonoids, glycosides, and fatty acids. These substances are essential for scavenging free radicals which helps in reducing inflammation, fending off infections, and hastening the healing of wounds. Bacterial species can survive in chronic wound conditions because biofilms employ quorum sensing as a communication technique which regulates the expression of virulence components. Fortunately, several phytochemicals have anti-QS characteristics that efficiently block QS pathways, prevent drug-resistant strains, and reduce biofilm development in chronic wounds. This review emphasizes the potential of phytocompounds as crucial agents for alleviating bacterial infections and promoting wound healing by reducing the inflammation in chronic wounds, exhibiting potential avenues for future therapeutic approaches to mitigate the healthcare burden provided by these challenging conditions. |
| first_indexed | 2024-03-07T21:54:26Z |
| format | Article |
| id | doaj.art-89886f8ef6a541dfa2bc8c2808644094 |
| institution | Directory Open Access Journal |
| issn | 1319-562X |
| language | English |
| last_indexed | 2024-04-25T00:04:57Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Journal of Biological Sciences |
| spelling | doaj.art-89886f8ef6a541dfa2bc8c28086440942024-03-14T06:14:08ZengElsevierSaudi Journal of Biological Sciences1319-562X2024-04-01314103963Deciphering the crosstalk between inflammation and biofilm in chronic wound healing: Phytocompounds loaded bionanomaterials as therapeuticsSrivarshini Sankar0Gothandam Kodiveri Muthukaliannan1Department of Biotechnology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore 632 014, Tamil Nadu, IndiaCorresponding author.; Department of Biotechnology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore 632 014, Tamil Nadu, IndiaIn terms of the economics and public health, chronic wounds exert a significant detrimental impact on the health care system. Bacterial infections, which cause the formation of highly resistant biofilms that elude standard antibiotics, are the main cause of chronic, non-healing wounds. Numerous studies have shown that phytochemicals are effective in treating a variety of diseases, and traditional medicinal plants often include important chemical groups such alkaloids, phenolics, tannins, terpenes, steroids, flavonoids, glycosides, and fatty acids. These substances are essential for scavenging free radicals which helps in reducing inflammation, fending off infections, and hastening the healing of wounds. Bacterial species can survive in chronic wound conditions because biofilms employ quorum sensing as a communication technique which regulates the expression of virulence components. Fortunately, several phytochemicals have anti-QS characteristics that efficiently block QS pathways, prevent drug-resistant strains, and reduce biofilm development in chronic wounds. This review emphasizes the potential of phytocompounds as crucial agents for alleviating bacterial infections and promoting wound healing by reducing the inflammation in chronic wounds, exhibiting potential avenues for future therapeutic approaches to mitigate the healthcare burden provided by these challenging conditions.http://www.sciencedirect.com/science/article/pii/S1319562X2400041XPhytochemicalsChronic woundsMolecular dockingInflammationQuorum sensing |
| spellingShingle | Srivarshini Sankar Gothandam Kodiveri Muthukaliannan Deciphering the crosstalk between inflammation and biofilm in chronic wound healing: Phytocompounds loaded bionanomaterials as therapeutics Saudi Journal of Biological Sciences Phytochemicals Chronic wounds Molecular docking Inflammation Quorum sensing |
| title | Deciphering the crosstalk between inflammation and biofilm in chronic wound healing: Phytocompounds loaded bionanomaterials as therapeutics |
| title_full | Deciphering the crosstalk between inflammation and biofilm in chronic wound healing: Phytocompounds loaded bionanomaterials as therapeutics |
| title_fullStr | Deciphering the crosstalk between inflammation and biofilm in chronic wound healing: Phytocompounds loaded bionanomaterials as therapeutics |
| title_full_unstemmed | Deciphering the crosstalk between inflammation and biofilm in chronic wound healing: Phytocompounds loaded bionanomaterials as therapeutics |
| title_short | Deciphering the crosstalk between inflammation and biofilm in chronic wound healing: Phytocompounds loaded bionanomaterials as therapeutics |
| title_sort | deciphering the crosstalk between inflammation and biofilm in chronic wound healing phytocompounds loaded bionanomaterials as therapeutics |
| topic | Phytochemicals Chronic wounds Molecular docking Inflammation Quorum sensing |
| url | http://www.sciencedirect.com/science/article/pii/S1319562X2400041X |
| work_keys_str_mv | AT srivarshinisankar decipheringthecrosstalkbetweeninflammationandbiofilminchronicwoundhealingphytocompoundsloadedbionanomaterialsastherapeutics AT gothandamkodiverimuthukaliannan decipheringthecrosstalkbetweeninflammationandbiofilminchronicwoundhealingphytocompoundsloadedbionanomaterialsastherapeutics |