Recent Discoveries of Diagnostic, Prognostic and Predictive Biomarkers for Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a dismal prognosis that is frequently diagnosed at an advanced stage. Although less common than other malignant diseases, it currently ranks as the fourth most common cause of cancer-related death in the European Union with a five...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/11/3234 |
| _version_ | 1797549051370012672 |
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| author | Andrii Khomiak Marius Brunner Maximilian Kordes Stina Lindblad Rainer Christoph Miksch Daniel Öhlund Ivonne Regel |
| author_facet | Andrii Khomiak Marius Brunner Maximilian Kordes Stina Lindblad Rainer Christoph Miksch Daniel Öhlund Ivonne Regel |
| author_sort | Andrii Khomiak |
| collection | DOAJ |
| description | Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a dismal prognosis that is frequently diagnosed at an advanced stage. Although less common than other malignant diseases, it currently ranks as the fourth most common cause of cancer-related death in the European Union with a five-year survival rate of below 9%. Surgical resection, followed by adjuvant chemotherapy, remains the only potentially curative treatment but only a minority of patients is diagnosed with locally resectable, non-metastatic disease. Patients with advanced disease are treated with chemotherapy but high rates of treatment resistance and unfavorable side-effect profiles of some of the used regimens remain major challenges. Biomarkers reflect pathophysiological or physiological processes linked to a disease and can be used as diagnostic, prognostic and predictive tools. Thus, accurate biomarkers can allow for better patient stratification and guide therapy choices. Currently, the only broadly used biomarker for PDAC, CA 19-9, has multiple limitations and the need for novel biomarkers is urgent. In this review, we highlight the current situation, recent discoveries and developments in the field of biomarkers of PDAC and their potential clinical applications. |
| first_indexed | 2024-03-10T15:09:11Z |
| format | Article |
| id | doaj.art-898a603cce7447d197d1cfbad1809962 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:09:11Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-898a603cce7447d197d1cfbad18099622023-11-20T19:30:53ZengMDPI AGCancers2072-66942020-11-011211323410.3390/cancers12113234Recent Discoveries of Diagnostic, Prognostic and Predictive Biomarkers for Pancreatic CancerAndrii Khomiak0Marius Brunner1Maximilian Kordes2Stina Lindblad3Rainer Christoph Miksch4Daniel Öhlund5Ivonne Regel6Shalimov National Institute of Surgery and Transplantology, 03058 Kyiv, UkraineDepartment of Gastroenterology, Endocrinology and Gastrointestinal Oncology, University Medical Center, 37075 Goettingen, GermanyDepartment of Upper Abdominal Diseases, Karolinska University Hospital, 14186 Stockholm, SwedenDepartment of Radiation Sciences, Sweden and Wallenberg Centre for Molecular Medicine, Umeå University, 90187 Umeå, SwedenDepartment of General, Visceral and Transplantation Surgery, University Hospital, LMU Munich, 81377 Munich, GermanyDepartment of Radiation Sciences, Sweden and Wallenberg Centre for Molecular Medicine, Umeå University, 90187 Umeå, SwedenDepartment of Medicine II, University Hospital, LMU Munich, 81377 Munich, GermanyPancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a dismal prognosis that is frequently diagnosed at an advanced stage. Although less common than other malignant diseases, it currently ranks as the fourth most common cause of cancer-related death in the European Union with a five-year survival rate of below 9%. Surgical resection, followed by adjuvant chemotherapy, remains the only potentially curative treatment but only a minority of patients is diagnosed with locally resectable, non-metastatic disease. Patients with advanced disease are treated with chemotherapy but high rates of treatment resistance and unfavorable side-effect profiles of some of the used regimens remain major challenges. Biomarkers reflect pathophysiological or physiological processes linked to a disease and can be used as diagnostic, prognostic and predictive tools. Thus, accurate biomarkers can allow for better patient stratification and guide therapy choices. Currently, the only broadly used biomarker for PDAC, CA 19-9, has multiple limitations and the need for novel biomarkers is urgent. In this review, we highlight the current situation, recent discoveries and developments in the field of biomarkers of PDAC and their potential clinical applications.https://www.mdpi.com/2072-6694/12/11/3234pancreatic ductal adenocarcinomapancreatic cancerprotein biomarkersmicrobiome biomarkersmetabolome biomarkersDNA biomarkers |
| spellingShingle | Andrii Khomiak Marius Brunner Maximilian Kordes Stina Lindblad Rainer Christoph Miksch Daniel Öhlund Ivonne Regel Recent Discoveries of Diagnostic, Prognostic and Predictive Biomarkers for Pancreatic Cancer Cancers pancreatic ductal adenocarcinoma pancreatic cancer protein biomarkers microbiome biomarkers metabolome biomarkers DNA biomarkers |
| title | Recent Discoveries of Diagnostic, Prognostic and Predictive Biomarkers for Pancreatic Cancer |
| title_full | Recent Discoveries of Diagnostic, Prognostic and Predictive Biomarkers for Pancreatic Cancer |
| title_fullStr | Recent Discoveries of Diagnostic, Prognostic and Predictive Biomarkers for Pancreatic Cancer |
| title_full_unstemmed | Recent Discoveries of Diagnostic, Prognostic and Predictive Biomarkers for Pancreatic Cancer |
| title_short | Recent Discoveries of Diagnostic, Prognostic and Predictive Biomarkers for Pancreatic Cancer |
| title_sort | recent discoveries of diagnostic prognostic and predictive biomarkers for pancreatic cancer |
| topic | pancreatic ductal adenocarcinoma pancreatic cancer protein biomarkers microbiome biomarkers metabolome biomarkers DNA biomarkers |
| url | https://www.mdpi.com/2072-6694/12/11/3234 |
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