Neurologic Complications of Cancer Immunotherapy
Immunotherapy has revolutionized cancer treatment over the past decade. As it is increasingly introduced into routine clinical practice, immune-related complications have become more frequent. Accurate diagnosis and treatment are essential, with the goal of reduced patient morbidity. This review aim...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/30/6/440 |
| _version_ | 1797595334279430144 |
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| author | Aseel N. Alsalem Leslie A. Scarffe Hannah R. Briemberg Ashley E. Aaroe Rebecca A. Harrison |
| author_facet | Aseel N. Alsalem Leslie A. Scarffe Hannah R. Briemberg Ashley E. Aaroe Rebecca A. Harrison |
| author_sort | Aseel N. Alsalem |
| collection | DOAJ |
| description | Immunotherapy has revolutionized cancer treatment over the past decade. As it is increasingly introduced into routine clinical practice, immune-related complications have become more frequent. Accurate diagnosis and treatment are essential, with the goal of reduced patient morbidity. This review aims to discuss the various clinical manifestations, diagnosis, treatments, and prognosis of neurologic complications associated with the use of immune checkpoint inhibitors, adoptive T-cell therapies, and T-cell redirecting therapies. We also outline a suggested clinical approach related to the clinical use of these agents. |
| first_indexed | 2024-03-11T02:35:54Z |
| format | Article |
| id | doaj.art-898a9dca830346d2b06bef3f133b778e |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-11T02:35:54Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-898a9dca830346d2b06bef3f133b778e2023-11-18T09:58:12ZengMDPI AGCurrent Oncology1198-00521718-77292023-06-013065876589710.3390/curroncol30060440Neurologic Complications of Cancer ImmunotherapyAseel N. Alsalem0Leslie A. Scarffe1Hannah R. Briemberg2Ashley E. Aaroe3Rebecca A. Harrison4Division of Neurology, University of British Columbia, Vancouver, BC V6T 2B5, CanadaDivision of Neurology, University of British Columbia, Vancouver, BC V6T 2B5, CanadaDivision of Neurology, University of British Columbia, Vancouver, BC V6T 2B5, CanadaDepartment of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADivision of Neurology, University of British Columbia, Vancouver, BC V6T 2B5, CanadaImmunotherapy has revolutionized cancer treatment over the past decade. As it is increasingly introduced into routine clinical practice, immune-related complications have become more frequent. Accurate diagnosis and treatment are essential, with the goal of reduced patient morbidity. This review aims to discuss the various clinical manifestations, diagnosis, treatments, and prognosis of neurologic complications associated with the use of immune checkpoint inhibitors, adoptive T-cell therapies, and T-cell redirecting therapies. We also outline a suggested clinical approach related to the clinical use of these agents.https://www.mdpi.com/1718-7729/30/6/440immunotherapyneurologic complicationscheckpoint inhibitionCAR-T cells |
| spellingShingle | Aseel N. Alsalem Leslie A. Scarffe Hannah R. Briemberg Ashley E. Aaroe Rebecca A. Harrison Neurologic Complications of Cancer Immunotherapy Current Oncology immunotherapy neurologic complications checkpoint inhibition CAR-T cells |
| title | Neurologic Complications of Cancer Immunotherapy |
| title_full | Neurologic Complications of Cancer Immunotherapy |
| title_fullStr | Neurologic Complications of Cancer Immunotherapy |
| title_full_unstemmed | Neurologic Complications of Cancer Immunotherapy |
| title_short | Neurologic Complications of Cancer Immunotherapy |
| title_sort | neurologic complications of cancer immunotherapy |
| topic | immunotherapy neurologic complications checkpoint inhibition CAR-T cells |
| url | https://www.mdpi.com/1718-7729/30/6/440 |
| work_keys_str_mv | AT aseelnalsalem neurologiccomplicationsofcancerimmunotherapy AT leslieascarffe neurologiccomplicationsofcancerimmunotherapy AT hannahrbriemberg neurologiccomplicationsofcancerimmunotherapy AT ashleyeaaroe neurologiccomplicationsofcancerimmunotherapy AT rebeccaaharrison neurologiccomplicationsofcancerimmunotherapy |