Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review
The process of skin carcinogenesis is still not fully understood. Both experimental and epidemiological evidence indicate that chronic inflammation is one of the hallmarks of microenvironmental-agent-mediated skin cancers and contributes to its development. Maintaining an inflammatory microenvironme...
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2021-04-01
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| author | Magdalena Ciążyńska Irmina Olejniczak-Staruch Dorota Sobolewska-Sztychny Joanna Narbutt Małgorzata Skibińska Aleksandra Lesiak |
| author_facet | Magdalena Ciążyńska Irmina Olejniczak-Staruch Dorota Sobolewska-Sztychny Joanna Narbutt Małgorzata Skibińska Aleksandra Lesiak |
| author_sort | Magdalena Ciążyńska |
| collection | DOAJ |
| description | The process of skin carcinogenesis is still not fully understood. Both experimental and epidemiological evidence indicate that chronic inflammation is one of the hallmarks of microenvironmental-agent-mediated skin cancers and contributes to its development. Maintaining an inflammatory microenvironment is a condition leading to tumor formation. Multiple studies focus on the molecular pathways activating tumorigenesis by inflammation and indicate several biomarkers and factors that can improve diagnostic and prognostic processes in oncology and dermatology. Reactive oxygen species produced by ultraviolet radiation, oxidizers, or metabolic processes can damage cells and initiate pro-inflammatory cascades. Considering the potential role of inflammation in cancer development and metastasis, the identification of early mechanisms involved in carcinogenesis is crucial for clinical practice and scientific research. Moreover, it could lead to the progress of advanced skin cancer therapies. We focus on a comprehensive analysis of available evidence and on understanding how chronic inflammation and ultraviolet radiation can result in skin carcinogenesis. We present the inflammatory environment as complex molecular networks triggering tumorigenesis and constituting therapeutic targets. |
| first_indexed | 2024-03-10T12:31:01Z |
| format | Article |
| id | doaj.art-898b7d1544e54f228833c41743d64f04 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T12:31:01Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-898b7d1544e54f228833c41743d64f042023-11-21T14:39:49ZengMDPI AGLife2075-17292021-04-0111432610.3390/life11040326Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative ReviewMagdalena Ciążyńska0Irmina Olejniczak-Staruch1Dorota Sobolewska-Sztychny2Joanna Narbutt3Małgorzata Skibińska4Aleksandra Lesiak5Department of Proliferative Diseases, Nicolaus Copernicus Multidisciplinary Centre for Oncology and Traumatology, 93-513 Łódź, PolandDepartment of Dermatology, Pediatric Dermatology and Dermatological Oncology, Medical University of Łódź, 90-419 Łódź, PolandDepartment of Dermatology, Pediatric Dermatology and Dermatological Oncology, Medical University of Łódź, 90-419 Łódź, PolandDepartment of Dermatology, Pediatric Dermatology and Dermatological Oncology, Medical University of Łódź, 90-419 Łódź, PolandDepartment of Dermatology, Pediatric Dermatology and Dermatological Oncology, Medical University of Łódź, 90-419 Łódź, PolandDepartment of Dermatology, Pediatric Dermatology and Dermatological Oncology, Medical University of Łódź, 90-419 Łódź, PolandThe process of skin carcinogenesis is still not fully understood. Both experimental and epidemiological evidence indicate that chronic inflammation is one of the hallmarks of microenvironmental-agent-mediated skin cancers and contributes to its development. Maintaining an inflammatory microenvironment is a condition leading to tumor formation. Multiple studies focus on the molecular pathways activating tumorigenesis by inflammation and indicate several biomarkers and factors that can improve diagnostic and prognostic processes in oncology and dermatology. Reactive oxygen species produced by ultraviolet radiation, oxidizers, or metabolic processes can damage cells and initiate pro-inflammatory cascades. Considering the potential role of inflammation in cancer development and metastasis, the identification of early mechanisms involved in carcinogenesis is crucial for clinical practice and scientific research. Moreover, it could lead to the progress of advanced skin cancer therapies. We focus on a comprehensive analysis of available evidence and on understanding how chronic inflammation and ultraviolet radiation can result in skin carcinogenesis. We present the inflammatory environment as complex molecular networks triggering tumorigenesis and constituting therapeutic targets.https://www.mdpi.com/2075-1729/11/4/326chronic inflammationinflammasomeskin carcinogenesismelanomanon-melanoma skin cancer |
| spellingShingle | Magdalena Ciążyńska Irmina Olejniczak-Staruch Dorota Sobolewska-Sztychny Joanna Narbutt Małgorzata Skibińska Aleksandra Lesiak Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review Life chronic inflammation inflammasome skin carcinogenesis melanoma non-melanoma skin cancer |
| title | Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review |
| title_full | Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review |
| title_fullStr | Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review |
| title_full_unstemmed | Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review |
| title_short | Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review |
| title_sort | ultraviolet radiation and chronic inflammation molecules and mechanisms involved in skin carcinogenesis a narrative review |
| topic | chronic inflammation inflammasome skin carcinogenesis melanoma non-melanoma skin cancer |
| url | https://www.mdpi.com/2075-1729/11/4/326 |
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