SR9009 improves heart function after pressure overload independent of cardiac REV-ERB

SR9009 improves heart function after pressure overload independent of cardiac REV-ERB

The core clock component REV-ERB is essential for heart function. Previous studies show that REV-ERB agonist SR9009 ameliorates heart remodeling in the pressure overload model with transverse aortic constriction (TAC). However, it is unknown whether SR9009 indeed works through cardiac REV-ERB, given...

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Bibliographic Details
Main Authors: Hui Li, Shiyang Song, Chih-liang Tien, Lei Qi, Andrea Graves, Eleni Nasiotis, Thomas P. Burris, Yuanbiao Zhao, Zheng Sun, Lilei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
circadian clock
REV-ERB
SR9009
TAC
heart disease
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.952114/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.952114/full

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